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PDB: 859 results
4DDU
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BU of 4ddu by Molmil
Thermotoga maritima reverse gyrase, C2 FORM 1
Descriptor: Reverse gyrase, ZINC ION
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2012-01-19
Release date:2012-12-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling.
Nucleic Acids Res., 41, 2013
4DDQ
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BU of 4ddq by Molmil
Structural plasticity of the Bacillus subtilis GyrA homodimer
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA gyrase subunit A, POTASSIUM ION
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2012-01-19
Release date:2013-02-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Mapping the Spectrum of Conformational States of the DNA- and C-Gates in Bacillus subtilis Gyrase.
J.Mol.Biol., 425, 2013
4DDT
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BU of 4ddt by Molmil
Thermotoga maritima reverse gyrase, C2 FORM 2
Descriptor: Reverse gyrase, ZINC ION
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2012-01-19
Release date:2012-12-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling.
Nucleic Acids Res., 41, 2013
4DDW
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BU of 4ddw by Molmil
Thermotoga maritima reverse gyrase, c-centered orthorhombic form
Descriptor: MAGNESIUM ION, PYROPHOSPHATE 2-, Reverse gyrase, ...
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2012-01-19
Release date:2012-12-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling.
Nucleic Acids Res., 41, 2013
4DDV
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BU of 4ddv by Molmil
Thermotoga maritima reverse gyrase, triclinic form
Descriptor: Reverse gyrase, ZINC ION
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2012-01-19
Release date:2012-12-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Crystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling.
Nucleic Acids Res., 41, 2013
3MWL
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BU of 3mwl by Molmil
Q28E mutant of HERA N-terminal RecA-like domain in complex with 8-OXOADENOSINE
Descriptor: 6-azanyl-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7H-purin-8-one, Heat resistant RNA dependent ATPase, SULFATE ION
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2010-05-06
Release date:2011-03-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop.
Biol.Chem., 392, 2011
3MWJ
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BU of 3mwj by Molmil
Q28E mutant of HERA N-terminal RecA-like domain, apo form
Descriptor: Heat resistant RNA dependent ATPase, SULFATE ION
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2010-05-06
Release date:2011-03-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop.
Biol.Chem., 392, 2011
3MWK
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BU of 3mwk by Molmil
Q28E mutant of HERA N-terminal RecA-like domain, complex with 8-oxo-AMP
Descriptor: Heat resistant RNA dependent ATPase, SULFATE ION, [(2R,3S,4R,5R)-5-(6-azanyl-8-oxo-7H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2010-05-06
Release date:2011-03-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop.
Biol.Chem., 392, 2011
3NBF
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BU of 3nbf by Molmil
Q28E mutant of hera helicase N-terminal domain bound to 8-oxo-ADP
Descriptor: Heat resistant RNA dependent ATPase, [(2R,3S,4R,5R)-5-(6-azanyl-8-oxo-7H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate, [(2R,3S,4R,5R)-5-(6-azanyl-8-oxo-7H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl phosphono hydrogen phosphate
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2010-06-03
Release date:2011-03-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop.
Biol.Chem., 392, 2011
3NEJ
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BU of 3nej by Molmil
Q28E mutant of Hera RNA helicase N-terminal domain - perfectly twinned hexagonal form
Descriptor: Heat resistant RNA dependent ATPase
Authors:Rudolph, M.G.
Deposit date:2010-06-09
Release date:2011-04-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Changing nucleotide specificity of the DEAD-box helicase Hera abrogates communication between the Q-motif and the P-loop.
Biol.Chem., 392, 2011
3OLF
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BU of 3olf by Molmil
Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid
Descriptor: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-26
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
3OOF
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BU of 3oof by Molmil
Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)benzoic acid
Descriptor: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)benzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-31
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
3P4Y
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BU of 3p4y by Molmil
Helicase domain of reverse gyrase from Thermotoga maritima - P2 form
Descriptor: reverse gyrase helicase domain
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2010-10-07
Release date:2011-06-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Conformational Flexibility of the Helicase-like Domain from Thermotoga maritima Reverse Gyrase Is Restricted by the Topoisomerase Domain.
Biochemistry, 50, 2011
3OOK
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BU of 3ook by Molmil
Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid
Descriptor: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-31
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
3OKI
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BU of 3oki by Molmil
Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide
Descriptor: (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-25
Release date:2010-12-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
Bioorg.Med.Chem.Lett., 21, 2010
3OMM
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BU of 3omm by Molmil
Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid
Descriptor: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-27
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
3P4X
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BU of 3p4x by Molmil
Helicase domain of reverse gyrase from Thermotoga maritima
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2010-10-07
Release date:2011-06-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:The Conformational Flexibility of the Helicase-like Domain from Thermotoga maritima Reverse Gyrase Is Restricted by the Topoisomerase Domain.
Biochemistry, 50, 2011
3OIY
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BU of 3oiy by Molmil
Helicase domain of reverse gyrase from Thermotoga maritima
Descriptor: CHLORIDE ION, PYROPHOSPHATE 2-, reverse gyrase helicase domain
Authors:Rudolph, M.G, Klostermeier, D.
Deposit date:2010-08-20
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The latch modulates nucleotide and DNA binding to the helicase-like domain of Thermotoga maritima reverse gyrase and is required for positive DNA supercoiling.
Nucleic Acids Res., 39, 2011
3OKH
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BU of 3okh by Molmil
Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid
Descriptor: 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-25
Release date:2010-12-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes
Bioorg.Med.Chem.Lett., 21, 2010
3OMK
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BU of 3omk by Molmil
Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide
Descriptor: (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1
Authors:Rudolph, M.G.
Deposit date:2010-08-27
Release date:2011-01-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21, 2011
1Y1E
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BU of 1y1e by Molmil
human formylglycine generating enzyme
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-alpha-formyglycine-generating enzyme, CALCIUM ION
Authors:Rudolph, M.G, Dickmanns, A, Ficner, R.
Deposit date:2004-11-18
Release date:2005-05-31
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.
Cell(Cambridge,Mass.), 121, 2005
1Y1I
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BU of 1y1i by Molmil
hyuman formylglycine generating enzyme, reduced form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-alpha-formyglycine-generating enzyme, CALCIUM ION
Authors:Rudolph, M.G, Dickmanns, A, Ficner, R.
Deposit date:2004-11-18
Release date:2005-05-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.
Cell(Cambridge,Mass.), 121, 2005
1Y1G
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BU of 1y1g by Molmil
Human formylglycine generating enzyme, double sulfonic acid form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-alpha-formyglycine-generating enzyme, CALCIUM ION
Authors:Rudolph, M.G, Dickmanns, A, Ficner, R.
Deposit date:2004-11-18
Release date:2005-05-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.
Cell(Cambridge,Mass.), 121, 2005
1Y1F
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BU of 1y1f by Molmil
human formylglycine generating enzyme with cysteine sulfenic acid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-alpha-formyglycine-generating enzyme, CALCIUM ION
Authors:Rudolph, M.G, Dickmanns, A, Ficner, R.
Deposit date:2004-11-18
Release date:2005-05-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.
Cell(Cambridge,Mass.), 121, 2005
1Y1H
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BU of 1y1h by Molmil
human formylglycine generating enzyme, oxidised Cys refined as hydroperoxide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-alpha-formyglycine-generating enzyme, HYDROGEN PEROXIDE, ...
Authors:Rudolph, M.G, Dickmanns, A, Ficner, R.
Deposit date:2004-11-18
Release date:2005-05-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme.
Cell(Cambridge,Mass.), 121, 2005

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