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PDB: 25 件
4XRO
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BU of 4xro by Molmil
Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I)
分子名称: Capsid protein p24
著者Price, A.J, James, L.C.
登録日2015-01-21
公開日2015-07-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
J.Virol., 89, 2015
4XRQ
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BU of 4xrq by Molmil
Disulfide stabilized HIV-1 CA hexamer 4mut (S41A, Q67H, V165I, L172I) in complex with PF-3450074
分子名称: Capsid protein p24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
著者Price, A.J, James, L.C.
登録日2015-01-21
公開日2015-07-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
J.Virol., 89, 2015
4IPZ
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BU of 4ipz by Molmil
SmBz bound to Cyclophilin A
分子名称: CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase A, cyclosporine SmBz-CsA
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2013-01-10
公開日2013-11-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献HIV-1 evades innate immune recognition through specific cofactor recruitment.
Nature, 503, 2013
5HGL
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BU of 5hgl by Molmil
Hexameric HIV-1 CA, open conformation
分子名称: CHLORIDE ION, Capsid protein P24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2016-01-08
公開日2016-08-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Nature, 536, 2016
4U0C
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BU of 4u0c by Molmil
Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form
分子名称: Capsid protein p24, Nuclear pore complex protein Nup153
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0A
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BU of 4u0a by Molmil
Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form
分子名称: CHLORIDE ION, Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0E
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BU of 4u0e by Molmil
Hexameric HIV-1 CA in complex with PF3450074
分子名称: CHLORIDE ION, Capsid protein p24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.043 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0B
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BU of 4u0b by Molmil
Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form
分子名称: Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0F
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BU of 4u0f by Molmil
Hexameric HIV-1 CA in Complex with BI-2
分子名称: (4S)-4-(4-hydroxyphenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one, 1,2-ETHANEDIOL, Capsid protein p24
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0D
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BU of 4u0d by Molmil
Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form
分子名称: CHLORIDE ION, Gag polyprotein, Nuclear pore complex protein Nup153
著者Price, A.J, Jacques, D.A, James, L.C.
登録日2014-07-11
公開日2014-11-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4B4N
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BU of 4b4n by Molmil
CPSF6 defines a conserved capsid interface that modulates HIV-1 replication
分子名称: CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6, GAG PROTEIN
著者Price, A.J, James, L.C.
登録日2012-07-31
公開日2012-09-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.813 Å)
主引用文献Cpsf6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication.
Plos Pathog., 8, 2012
4LQW
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BU of 4lqw by Molmil
Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin
分子名称: Capsid protein p24, E3 SUMO-protein ligase RanBP2
著者Price, A.J, James, L.C.
登録日2013-07-19
公開日2013-08-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358.
Retrovirology, 10, 2013
2WLW
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BU of 2wlw by Molmil
Structure of the N-terminal capsid domain of HIV-2
分子名称: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C.
登録日2009-06-26
公開日2009-09-22
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp
Nat.Struct.Mol.Biol., 16, 2009
2WLV
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BU of 2wlv by Molmil
Structure of the N-terminal capsid domain of HIV-2
分子名称: GAG POLYPROTEIN
著者Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C.
登録日2009-06-26
公開日2009-09-22
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp
Nat.Struct.Mol.Biol., 16, 2009
2X82
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BU of 2x82 by Molmil
Evolutionary basis of HIV restriction by the antiretroviral TRIMCyp
分子名称: CAPSID PROTEIN P24
著者Price, A.J, James, L.C.
登録日2010-03-05
公開日2010-09-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Conformational Adaptation of Asian Macaque Trimcyp Directs Lineage Specific Antiviral Activity.
Plos Pathog., 6, 2010
2X83
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BU of 2x83 by Molmil
Evolutionary basis of HIV restriction by the antiretroviral TRIMCyp
分子名称: HIV-1 CAPSID, TRIM5/CypA fusion protein
著者Price, A.J, James, L.C.
登録日2010-03-05
公開日2010-09-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.
Plos Pathog., 6, 2010
4YIW
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BU of 4yiw by Molmil
DIHYDROOROTASE FROM BACILLUS ANTHRACIS WITH SUBSTRATE BOUND
分子名称: Dihydroorotase, N-CARBAMOYL-L-ASPARTATE, ZINC ION
著者Lei, H, Santarsiero, B.D, Rice, A.J, Lee, H, Johnson, M.E.
登録日2015-03-02
公開日2016-08-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase).
Bioorg.Med.Chem., 24, 2016
5HGK
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BU of 5hgk by Molmil
HIV-1 CA N-terminal domain, open conformation
分子名称: CHLORIDE ION, Capsid protein
著者Jacques, D.A, Price, A.J, James, L.C.
登録日2016-01-08
公開日2016-08-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.763 Å)
主引用文献HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Nature, 536, 2016
5HGN
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BU of 5hgn by Molmil
Hexameric HIV-1 CA, apo form
分子名称: Capsid protein P24
著者Jacques, D.A, Price, A.J, James, D.A.
登録日2016-01-08
公開日2016-08-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Nature, 536, 2016
2JGD
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BU of 2jgd by Molmil
E. COLI 2-oxoglutarate dehydrogenase (E1o)
分子名称: 2-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT, ADENOSINE MONOPHOSPHATE
著者Frank, R.A.W, Price, A.J, Northrop, F.D, Perham, R.N, Luisi, B.F.
登録日2007-02-12
公開日2007-02-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of the E1 Component of the Escherichia Coli 2-Oxoglutarate Dehydrogenase Multienzyme Complex.
J.Mol.Biol., 368, 2007
4DGA
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BU of 4dga by Molmil
TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex
分子名称: TRIMCyp, capsid protein
著者Caines, M.E.C, Bichel, K, Price, A.J, McEwan, W.A, James, L.C.
登録日2012-01-25
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Nat.Struct.Mol.Biol., 19, 2012
4DGC
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BU of 4dgc by Molmil
TRIMCyp cyclophilin domain from Macaca mulatta: cyclosporin A complex
分子名称: TRIMCyp, cyclosporin A
著者Caines, M.E.C, Bichel, K, Price, A.J, McEwan, W.A, James, L.C.
登録日2012-01-25
公開日2012-02-08
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Nat.Struct.Mol.Biol., 19, 2012
4DGD
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BU of 4dgd by Molmil
TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant
分子名称: GLYCEROL, TRIMCyp
著者Caines, M.E.C, Bichel, K, Price, A.J, McEwan, W.A, James, L.C.
登録日2012-01-25
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Nat.Struct.Mol.Biol., 19, 2012
4DGB
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BU of 4dgb by Molmil
TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex
分子名称: TRIMCyp, capsid protein
著者Caines, M.E.C, Bichel, K, Price, A.J, McEwan, W.A, James, L.C.
登録日2012-01-25
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.702 Å)
主引用文献Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Nat.Struct.Mol.Biol., 19, 2012
4DGE
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BU of 4dge by Molmil
TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex
分子名称: TRIMCyp, capsid protein
著者Caines, M.E.C, Bichel, K, Price, A.J, McEwan, W.A, James, L.C.
登録日2012-01-25
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Nat.Struct.Mol.Biol., 19, 2012

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