2W3M
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2W3A
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![BU of 2w3a by Molmil](/molmil-images/mine/2w3a) | |
2C2T
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![BU of 2c2t by Molmil](/molmil-images/mine/2c2t) | Human Dihydrofolate Reductase Complexed With NADPH and 2,4-Diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6-methylpyrimidine, a novel boron containing, nonclassical Antifolate | 分子名称: | (S)-2,4-DIAMINO-5-((7,8-DICARBAUNDECABORAN-7-YL)METHYL)-6-METHYLPYRIMIDINE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ... | 著者 | leung, A.K.W, reynolds, R.C, riordan, J.M, borhani, D.W. | 登録日 | 2005-09-30 | 公開日 | 2007-04-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation. J.Med.Chem., 50, 2007
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2C2S
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![BU of 2c2s by Molmil](/molmil-images/mine/2c2s) | Human Dihydrofolate Reductase Complexed With NADPH and 2,4-Diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, A novel boron containing, nonclassical Antifolate | 分子名称: | 2,4-DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ... | 著者 | Leung, A.K.W, Reynolds, R.C, Riordan, J.M, Borhani, D.W. | 登録日 | 2005-09-29 | 公開日 | 2007-04-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation. J.Med.Chem., 50, 2007
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1RQ7
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![BU of 1rq7 by Molmil](/molmil-images/mine/1rq7) | MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH GDP | 分子名称: | Cell division protein ftsZ, GUANOSINE-5'-DIPHOSPHATE | 著者 | Leung, A.K.W, White, E.L, Ross, L.J, Reynolds, R.C, DeVito, J.A, Borhani, D.W. | 登録日 | 2003-12-04 | 公開日 | 2004-08-31 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J.Mol.Biol., 342, 2004
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1RLU
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![BU of 1rlu by Molmil](/molmil-images/mine/1rlu) | Mycobacterium tuberculosis FtsZ in complex with GTP-gamma-S | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Cell division protein ftsZ, GLYCEROL | 著者 | Leung, A.K.W, White, E.L, Ross, L.J, Reynolds, R.C, DeVito, J.A, Borhani, D.W. | 登録日 | 2003-11-26 | 公開日 | 2004-08-31 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J.Mol.Biol., 342, 2004
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1RQ2
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![BU of 1rq2 by Molmil](/molmil-images/mine/1rq2) | MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH CITRATE | 分子名称: | CITRIC ACID, Cell division protein ftsZ | 著者 | Leung, A.K.W, White, E.L, Ross, L.J, Reynolds, R.C, DeVito, J.A, Borhani, D.W. | 登録日 | 2003-12-04 | 公開日 | 2004-08-31 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J.Mol.Biol., 342, 2004
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2W3B
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![BU of 2w3b by Molmil](/molmil-images/mine/2w3b) | HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686) | 分子名称: | 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE, FOLIC ACID, ... | 著者 | Leung, A.K.W, Reynolds, R.C, Borhani, D.W. | 登録日 | 2008-11-11 | 公開日 | 2009-11-17 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate To be Published
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2W3W
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![BU of 2w3w by Molmil](/molmil-images/mine/2w3w) | MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR M. AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686) | 分子名称: | 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Leung, A.K.W, Reynolds, R.C, Borhani, D.W. | 登録日 | 2008-11-16 | 公開日 | 2009-11-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate To be Published
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2W3V
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