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PDB: 776 results

1JTY
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Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium
Descriptor: ETHIDIUM, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION
Authors:Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G.
Deposit date:2001-08-22
Release date:2001-12-12
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
1JUM
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Crystal structure of the multidrug binding transcriptional repressor QacR bound to the natural drug berberine
Descriptor: BERBERINE, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION
Authors:Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G.
Deposit date:2001-08-24
Release date:2001-12-12
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
1JT6
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Crystal structure of the multidrug binding protein QacR bound to dequalinium
Descriptor: DEQUALINIUM, Hypothetical transcriptional regulator IN QACA 5'region, SULFATE ION
Authors:Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G.
Deposit date:2001-08-20
Release date:2001-12-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural mechanisms of QacR induction and multidrug recognition.
Science, 294, 2001
1TTJ
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THREE NEW CRYSTAL STRUCTURES OF POINT MUTATION VARIANTS OF MONOTIM: CONFORMATIONAL FLEXIBILITY OF LOOP-1,LOOP-4 AND LOOP-8
Descriptor: PHOSPHOGLYCOLOHYDROXAMIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Radha Kishan, K.V, Wierenga, R.K.
Deposit date:1995-04-20
Release date:1995-09-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three new crystal structures of point mutation variants of monoTIM: conformational flexibility of loop-1, loop-4 and loop-8.
Structure, 3, 1995
1TMH
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MODULAR MUTAGENESIS OF A TIM-BARREL ENZYME: THE CRYSTAL STRUCTURE OF A CHIMERIC E. COLI TIM HAVING THE EIGHTH (BETA-ALPHA)-UNIT REPLACED BY THE EQUIVALENT UNIT OF CHICKEN TIM
Descriptor: SULFATE ION, TRIOSEPHOSPHATE ISOMERASE
Authors:Radha Kishan, K.V, Zeelen, J.Ph, Wierenga, R.K.
Deposit date:1994-03-22
Release date:1994-06-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Modular mutagenesis of a TIM-barrel enzyme: the crystal structure of a chimeric E. coli TIM having the eighth beta alpha-unit replaced by the equivalent unit of chicken TIM.
Protein Eng., 7, 1994
1TRD
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THE INFLUENCE OF CRYSTAL PACKING ON CRYSTALLOGRAPHIC BINDING STUDIES: A NEW CRYSTAL FORM OF TRYPANOSOMAL TIM
Descriptor: PHOSPHOGLYCOLOHYDROXAMIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Wierenga, R.K.
Deposit date:1992-10-06
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the "open" and "closed" state of trypanosomal triosephosphate isomerase, as observed in a new crystal form: implications for the reaction mechanism.
Proteins, 16, 1993
1TRE
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THE STRUCTURE OF TRIOSEPHOSPHATE ISOMERASE FROM ESCHERICHIA COLI DETERMINED AT 2.6 ANGSTROM RESOLUTION
Descriptor: TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Wierenga, R.K.
Deposit date:1992-10-12
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of triosephosphate isomerase from Escherichia coli determined at 2.6 A resolution.
Acta Crystallogr.,Sect.D, 49, 1993
4UWJ
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Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a capped pyrazole sulphonamide ligand
Descriptor: 2,6-dichloro-N-(difluoromethyl)-4-[3-(piperidin-4-yl)propyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA
Authors:Robinson, D.A, Brand, S, Norcross, N.R, Thompson, S, Harrison, J.R, Smith, V.C, Torrie, L.S, McElroy, S.P, Hallyburton, I, Norval, S, Stojanovski, L, Simeons, F.R.C, Frearson, J.A, Brenk, R, Fairlamb, A.H, Ferguson, M.A.J, Wyatt, P.G, Gilbert, I.H, Read, K.D.
Deposit date:2014-08-12
Release date:2014-12-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
J. Med. Chem., 57, 2014
4UWI
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Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand
Descriptor: 2,6-dichloro-4-[3-(4-methylpiperazin-1-yl)propyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA
Authors:Robinson, D.A, Brand, S, Norcross, N.R, Thompson, S, Harrison, J.R, Smith, V.C, Torrie, L.S, McElroy, S.P, Hallyburton, I, Norval, S, Stojanovski, L, Simeons, F.R.C, Frearson, J.A, Brenk, R, Fairlamb, A.H, Ferguson, M.A.J, Wyatt, P.G, Gilbert, I.H, Read, K.D.
Deposit date:2014-08-12
Release date:2014-12-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
J. Med. Chem., 57, 2014
1JH9
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PURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX
Descriptor: 5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T)-3', HYPOXANTHINE, PHOSPHATE ION, ...
Authors:Huffman, J.L, Lu, F, Zalkin, H, Brennan, R.G.
Deposit date:2001-06-27
Release date:2002-02-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
1JHZ
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Purine Repressor Mutant Corepressor Binding Domain Structure
Descriptor: MAGNESIUM ION, PURINE NUCLEOTIDE SYNTHESIS REPRESSOR
Authors:Huffman, J.L, Lu, F, Zalkin, H, Brennan, R.G.
Deposit date:2001-06-28
Release date:2002-02-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry, 41, 2002
1TPD
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BU of 1tpd by Molmil
STRUCTURES OF THE "OPEN" AND "CLOSED" STATE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE, AS OBSERVED IN A NEW CRYSTAL FORM: IMPLICATIONS FOR THE REACTION MECHANISM
Descriptor: TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Zeelen, J.Ph, Wierenga, R.K.
Deposit date:1994-02-28
Release date:1994-05-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of the "open" and "closed" state of trypanosomal triosephosphate isomerase, as observed in a new crystal form: implications for the reaction mechanism.
Proteins, 16, 1993
1TPE
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COMPARISON OF THE STRUCTURES AND THE CRYSTAL CONTACTS OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE IN FOUR DIFFERENT CRYSTAL FORMS
Descriptor: TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Radha Kishan, K.V, Zeelen, J.Ph, Wierenga, R.K.
Deposit date:1994-02-28
Release date:1994-05-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparison of the structures and the crystal contacts of trypanosomal triosephosphate isomerase in four different crystal forms.
Protein Sci., 3, 1994
4U1A
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Crystal structure of human peroxisomal delta3,delta2, enoyl-CoA isomerase helix-10 deletion mutant (ISOB-ECI2)
Descriptor: CHLORIDE ION, Enoyl-CoA delta isomerase 2
Authors:Onwukwe, G.U, Koski, M.K, Wierenga, R.K.
Deposit date:2014-07-15
Release date:2014-12-24
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Human Delta (3) , Delta (2) -enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.
Febs J., 282, 2015
4U19
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Crystal structure of human peroxisomal delta3,delta2, enoyl-CoA isomerase V349A mutant (ISOA-ECI2)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Enoyl-CoA delta isomerase 2
Authors:Onwukwe, G.U, Koski, M.K, Wierenga, R.K.
Deposit date:2014-07-15
Release date:2014-12-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Human Delta (3) , Delta (2) -enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.
Febs J., 282, 2015
4U18
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Crystal structure of human peroxisomal delta3,delta2, enoyl-CoA isomerase (ISO-ECI2)
Descriptor: CHLORIDE ION, Enoyl-CoA delta isomerase 2, mitochondrial, ...
Authors:Onwukwe, G.U, Koski, M.K, Wierenga, R.K.
Deposit date:2014-07-15
Release date:2014-12-24
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human Delta (3) , Delta (2) -enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.
Febs J., 282, 2015
4QQ0
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CdsD - The structural protein of the Type III secretion system of Chlamydia trachomatis: C-terminal domain
Descriptor: Adenylate cyclase-like protein, SULFATE ION
Authors:Merilainen, G, Wierenga, R.K.
Deposit date:2014-06-26
Release date:2015-07-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis.
Protein Sci., 25, 2016
4TIM
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CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDIES ON TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: A CRITICAL ASSESSMENT OF THE PREDICTED AND OBSERVED STRUCTURES OF THE COMPLEX WITH 2-PHOSPHOGLYCERATE
Descriptor: 2-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Nobel, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-11
Release date:1992-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.
J.Med.Chem., 34, 1991
7PPS
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BU of 7pps by Molmil
apo FabB from Pseudomonas aeruginosa with single point mutation C161A
Descriptor: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 1, CHLORIDE ION, ...
Authors:Georgiou, C, Brenk, R, Yadrykhinsky, V.
Deposit date:2021-09-15
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics.
F1000Res, 10, 2021
8PMJ
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Vanadate-trapped BSEP in nanodiscs
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, ...
Authors:Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
Deposit date:2023-06-28
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
8PMD
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Nucleotide-bound BSEP in nanodiscs
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, MAGNESIUM ION
Authors:Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
Deposit date:2023-06-28
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
8PM6
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Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs
Descriptor: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL
Authors:Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
Deposit date:2023-06-28
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
8B5S
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Crystal Structure of P. aeruginosa WaaG in complex with UDP-glucose
Descriptor: UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-DIPHOSPHATE, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Scaletti, E, Gustafsson Westergren, R, Stenmark, P.
Deposit date:2022-09-24
Release date:2023-10-04
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
8B5Q
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Crystal Structure of P. aeruginosa WaaG in complex with UMP
Descriptor: UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG, URIDINE-5'-MONOPHOSPHATE
Authors:Scaletti, E, Gustafsson Westergren, R, Stenmark, P.
Deposit date:2022-09-24
Release date:2023-10-04
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023
8B62
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Crystal Structure of P. aeruginosa WaaG in complex with UDP-galactose
Descriptor: GALACTOSE-URIDINE-5'-DIPHOSPHATE, GLYCEROL, UDP-glucose:(Heptosyl) LPS alpha 1,3-glucosyltransferase WaaG
Authors:Scaletti, E, Gustafsson Westergren, R, Stenmark, P.
Deposit date:2022-09-25
Release date:2023-10-04
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J.Biol.Chem., 299, 2023

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數據於2024-06-26公開中

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