6UW1
 
 | | The crystal structure of FbiA from Mycobacterium Smegmatis, Fo bound form | | 分子名称: | 1-deoxy-1-(8-hydroxy-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-D-ribitol, CALCIUM ION, Phosphoenolpyruvate transferase | | 著者 | Grinter, R, Gillett, D, Cordero, P.R.F, Greening, C. | | 登録日 | 2019-11-04 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.205 Å) | | 主引用文献 | Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria.
mSystems, 5, 2020
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6EOR
 | | DPP9 - 1G244 | | 分子名称: | (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione, Dipeptidyl peptidase 9 | | 著者 | Ross, B.R, Huber, R. | | 登録日 | 2017-10-10 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4QI8
 | | Lytic polysaccharide monooxygenase 9F from Neurospora crassa, NcLPMO9F | | 分子名称: | COPPER (II) ION, Lytic polysaccharide monooxygenase, NITRATE ION | | 著者 | Tan, T.C, Gandini, R, Sygmund, C, Kittl, R, Haltrich, D, Ludwig, R, Hallberg, B.M, Divne, C. | | 登録日 | 2014-05-30 | | 公開日 | 2015-07-15 | | 最終更新日 | 2018-03-07 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
Nat Commun, 6, 2015
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7AKW
 | | Crystal structure of the viral rhodopsins chimera O1O2 | | 分子名称: | EICOSANE, RETINAL, chimera of viral rhodopsins OLPVR1 and OLPVRII | | 著者 | Kovalev, K, Zabelskii, D, Alekseev, A, Astashkin, R, Gordeliy, V. | | 登録日 | 2020-10-02 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Viral rhodopsins 1 are an unique family of light-gated cation channels.
Nat Commun, 11, 2020
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7AKY
 | | Crystal structure of the viral rhodopsin OLPVR1 in P21212 space group | | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, EICOSANE, viral rhodopsin OLPVR1 | | 著者 | Kovalev, K, Zabelskii, D, Alekseev, A, Astashkin, R, Gordeliy, V. | | 登録日 | 2020-10-02 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Viral rhodopsins 1 are an unique family of light-gated cation channels.
Nat Commun, 11, 2020
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1WLA
 | | MYOGLOBIN (HORSE HEART) RECOMBINANT WILD-TYPE | | 分子名称: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | 著者 | Maurus, R, Brayer, G.D. | | 登録日 | 1997-09-24 | | 公開日 | 1998-01-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket.
Biochim.Biophys.Acta, 1341, 1997
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6Y8K
 | | Crystal structure of CD137 in complex with the cyclic peptide BCY10916 | | 分子名称: | 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, 1,2-ETHANEDIOL, ACETATE ION, ... | | 著者 | Upadhyaya, P, Kublin, J, Dods, R, Kristensson, J, Lahdenranta, J, Kleyman, M, Repash, E, Ma, J, Mudd, G, Van Rietschoten, K, Haines, E, Harrison, H, Beswick, P, Chen, L, McDonnell, K, Battula, S, Hurov, K, Keen, N. | | 登録日 | 2020-03-05 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | | 主引用文献 | Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist.
J Immunother Cancer, 9, 2021
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4QI3
 | | Cytochrome domain of Myriococcum thermophilum cellobiose dehydrogenase, MtCYT | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cellobiose dehydrogenase, MAGNESIUM ION, ... | | 著者 | Tan, T.C, Gandini, R, Sygmund, C, Kittl, R, Haltrich, D, Ludwig, R, Hallberg, B.M, Divne, C. | | 登録日 | 2014-05-30 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
Nat Commun, 6, 2015
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6EOQ
 | | DPP9 - Apo | | 分子名称: | Dipeptidyl peptidase 9 | | 著者 | Ross, B.R, Huber, R. | | 登録日 | 2017-10-10 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5I9K
 | | The structure of microsomal glutathione transferase 1 | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTATHIONE, Microsomal glutathione S-transferase 1, ... | | 著者 | Kuang, Q, Purhonen, P, Jegerschold, C, Morgenstern, R, Hebert, H. | | 登録日 | 2016-02-20 | | 公開日 | 2017-07-12 | | 最終更新日 | 2017-08-23 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3.5 Å) | | 主引用文献 | Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation.
Sci Rep, 7, 2017
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7AKX
 | | Crystal structure of the viral rhodopsin OLPVR1 in P1 space group | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, EICOSANE, OLEIC ACID, ... | | 著者 | Kovalev, K, Zabelskii, D, Alekseev, A, Astashkin, R, Gordeliy, V. | | 登録日 | 2020-10-02 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Viral rhodopsins 1 are an unique family of light-gated cation channels.
Nat Commun, 11, 2020
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5IA9
 | | The structure of microsomal glutathione transferase 1 in complex with Meisenheimer complex | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE, Microsomal glutathione S-transferase 1, ... | | 著者 | Kuang, Q, Purhonen, P, Jegerschold, C, Morgenstern, R, Hebert, H. | | 登録日 | 2016-02-21 | | 公開日 | 2017-07-12 | | 最終更新日 | 2017-08-23 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3.5 Å) | | 主引用文献 | Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation.
Sci Rep, 7, 2017
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8FOJ
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state | | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | 登録日 | 2022-12-30 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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4QI6
 | | Cellobiose dehydrogenase from Myriococcum thermophilum, MtCDH | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cellobiose dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Tan, T.C, Gandini, R, Sygmund, C, Kittl, R, Haltrich, D, Ludwig, R, Hallberg, B.M, Divne, C. | | 登録日 | 2014-05-30 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
Nat Commun, 6, 2015
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8FOH
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state | | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | 登録日 | 2022-12-30 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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6XZW
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8FOC
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase in Apo state conformation I | | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | 登録日 | 2022-12-30 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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5IIT
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6SGN
 | | Crystal structure of monooxygenase RutA complexed with 2,4-dimethoxypyrimidine. | | 分子名称: | 2,4-dimethoxypyrimidine, FLAVIN MONONUCLEOTIDE, Pyrimidine monooxygenase RutA | | 著者 | Saleem-Batcha, R, Matthews, A, Teufel, R. | | 登録日 | 2019-08-05 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases.
Nat.Chem.Biol., 16, 2020
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8FOE
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA | | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | 登録日 | 2022-12-30 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOD
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II | | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | 登録日 | 2022-12-30 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOK
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state | | 分子名称: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | 著者 | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | 登録日 | 2022-12-30 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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7AVY
 | | MerTK kinase domain in complex with quinazoline-based inhbitor | | 分子名称: | N-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine, SULFATE ION, Tyrosine-protein kinase Mer | | 著者 | Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S. | | 登録日 | 2020-11-06 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J.Med.Chem., 64, 2021
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5IJH
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7AVX
 | | MerTK kinase domain in complex with NPS-1034 | | 分子名称: | 1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide, Tyrosine-protein kinase Mer | | 著者 | Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S. | | 登録日 | 2020-11-06 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J.Med.Chem., 64, 2021
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