4ZEX
 
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4MEZ
 | | Crystal structure of M68L/M69T double mutant TEM-1 | | 分子名称: | Beta-lactamase TEM, CHLORIDE ION, GLYCEROL, ... | | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | | 登録日 | 2013-08-27 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | | 主引用文献 | The Structural Dynamics of Engineered beta-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.
Sci Rep, 9, 2019
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4LPH
 | | Crystal structure of human FPPS in complex with CL03093 | | 分子名称: | ({[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl)phosphonic acid, Farnesyl pyrophosphate synthase, PHOSPHATE ION | | 著者 | Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-07-16 | | 公開日 | 2014-06-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.
J.Med.Chem., 57, 2014
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4H5C
 | | Crystal structure of human FPPS in ternary complex with YS0470 and inorganic phosphate | | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2012-09-18 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
Bmc Struct.Biol., 12, 2012
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4H5E
 | | Crystal structure of human FPPS in ternary complex with YS0470 and isopentenyl pyrophosphate | | 分子名称: | Farnesyl pyrophosphate synthase, ISOPENTYL PYROPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2012-09-18 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
Bmc Struct.Biol., 12, 2012
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4H5D
 | | Crystal structure of human FPPS in ternary complex with YS0470 and inorganic pyrophosphate | | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | 著者 | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2012-09-18 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.
Bmc Struct.Biol., 12, 2012
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4ID4
 | | Crystal structure of chimeric beta-lactamase cTEM-17m | | 分子名称: | Beta-lactamase TEM, Beta-lactamase PSE-4, CHLORIDE ION, ... | | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | | 登録日 | 2012-12-11 | | 公開日 | 2013-12-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins.
Chem.Biol., 21, 2014
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4JVJ
 | | Crystal structure of human FPPS in complex with magnesium, CL01131, and sulfate | | 分子名称: | ({[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methanediyl)bis(phosphonic acid), Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | | 著者 | Park, J, Leung, C.-Y, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-03-25 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition.
J.Med.Chem., 56, 2013
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4R4R
 | | Crystal structure of chimeric beta-lactamase cTEM-19m at 1.2 angstrom resolution | | 分子名称: | Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION | | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | | 登録日 | 2014-08-19 | | 公開日 | 2015-11-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | The Structural Dynamics of Engineered beta-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.
Sci Rep, 9, 2019
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4L2X
 | | Crystal structure of human FPPS in complex with magnesium, CL02134, and inorganic pyrophosphate | | 分子名称: | ({[6-(4-cyclopropylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methanediyl)bis(phosphonic acid), Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | | 著者 | Park, J, Leung, C.-Y, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-06-04 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition.
J.Med.Chem., 56, 2013
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4R4S
 | | Crystal structure of chimeric beta-lactamase cTEM-19m at 1.1 angstrom resolution | | 分子名称: | Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION | | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | | 登録日 | 2014-08-19 | | 公開日 | 2015-11-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | The Structural Dynamics of Engineered beta-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function.
Sci Rep, 9, 2019
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4LFV
 | | Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate | | 分子名称: | CHLORIDE ION, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | | 著者 | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-06-27 | | 公開日 | 2014-03-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate.
Acta Crystallogr F Struct Biol Commun, 70, 2014
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6KBM
 | | Crystal structure of Vac8 bound to Atg13 | | 分子名称: | Autophagy-related protein 13, Vacuolar protein 8 | | 著者 | Park, J, Lee, C. | | 登録日 | 2019-06-25 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.902 Å) | | 主引用文献 | Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways.
Autophagy, 16, 2020
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6KBN
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5TUE
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5TUI
 | | Crystal structure of tetracycline destructase Tet(50) in complex with chlortetracycline | | 分子名称: | 7-CHLOROTETRACYCLINE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... | | 著者 | Park, J, Tolia, N.H. | | 登録日 | 2016-11-06 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol., 13, 2017
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5TUK
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5TUM
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5TUF
 | | Crystal structure of tetracycline destructase Tet(50) in complex with anhydrotetracycline | | 分子名称: | 5A,6-ANHYDROTETRACYCLINE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... | | 著者 | Park, J, Tolia, N.H. | | 登録日 | 2016-11-06 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol., 13, 2017
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5TUL
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4NFJ
 | | Crystal structure of human FPPS in complex with magnesium, JDS05120, and sulfate | | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Park, J, De Schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-10-31 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017
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4NFI
 | | Crystal structure of human FPPS in complex with magnesium and JDS05120 | | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [({5-[4-(cyclopropyloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid) | | 著者 | Park, J, De Schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-10-31 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017
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4NFK
 | | Crystal structure of human FPPS in complex with nickel, JDS05120, and sulfate | | 分子名称: | Farnesyl pyrophosphate synthase, NICKEL (II) ION, SULFATE ION, ... | | 著者 | Park, J, De schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-10-31 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017
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7M99
 | | ATPgS bound TnsC filament from ShCAST system | | 分子名称: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... | | 著者 | Park, J, Tsai, A.W.L, Mehrotra, E, Kellogg, E.H. | | 登録日 | 2021-03-30 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for target site selection in RNA-guided DNA transposition systems.
Science, 373, 2021
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7M9A
 | | ADP-AlF3 bound TnsC structure from ShCAST system | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (27-MER), TnsC | | 著者 | Park, J, Tsai, A.W.L, Mehrotra, E, Kellogg, E.H. | | 登録日 | 2021-03-30 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis for target site selection in RNA-guided DNA transposition systems.
Science, 373, 2021
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