5Z7A
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![BU of 5z7a by Molmil](/molmil-images/mine/5z7a) | Crystal structure of NDP52 SKICH region | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL, ... | Authors: | Pan, L.F, Fu, T, Liu, J.P, Xie, X.Q. | Deposit date: | 2018-01-27 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5Z7G
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![BU of 5z7g by Molmil](/molmil-images/mine/5z7g) | Crystal structure of TAX1BP1 SKICH region in complex with NAP1 | Descriptor: | 5-azacytidine-induced protein 2, GLYCEROL, Tax1-binding protein 1 | Authors: | Pan, L.F, Fu, T, Liu, J.P, Xie, X.Q, Wang, Y.L, Hu, S.C. | Deposit date: | 2018-01-28 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8K6Q
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![BU of 8k6q by Molmil](/molmil-images/mine/8k6q) | Crystal structure of HOIL-1L LTM domain | Descriptor: | RanBP-type and C3HC4-type zinc finger-containing protein 1 | Authors: | Yan, Z, Pan, L.F. | Deposit date: | 2023-07-25 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN. Biochem.Biophys.Res.Commun., 689, 2023
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8K6P
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![BU of 8k6p by Molmil](/molmil-images/mine/8k6p) | Crystal structure of SHARPIN LTM motif | Descriptor: | Sharpin | Authors: | Yan, Z, Pan, L.F. | Deposit date: | 2023-07-25 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN. Biochem.Biophys.Res.Commun., 689, 2023
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8W6A
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![BU of 8w6a by Molmil](/molmil-images/mine/8w6a) | |
8W6B
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![BU of 8w6b by Molmil](/molmil-images/mine/8w6b) | |
7C7J
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![BU of 7c7j by Molmil](/molmil-images/mine/7c7j) | |
7C7I
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![BU of 7c7i by Molmil](/molmil-images/mine/7c7i) | |
7CWW
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![BU of 7cww by Molmil](/molmil-images/mine/7cww) | Crystal structure of TsrL | Descriptor: | 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontane-1,38-diol, TsrE | Authors: | Li, Y, Pan, L.F. | Deposit date: | 2020-08-31 | Release date: | 2021-09-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | crystal structure of TsrL To Be Published
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3PVL
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![BU of 3pvl by Molmil](/molmil-images/mine/3pvl) | Structure of myosin VIIa MyTH4-FERM-SH3 in complex with the CEN1 of Sans | Descriptor: | GLYCEROL, Myosin VIIa isoform 1, PHOSPHATE ION, ... | Authors: | Wu, L, Pan, L.F, Wei, Z.Y, Zhang, M.J. | Deposit date: | 2010-12-07 | Release date: | 2011-03-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo. Science, 331, 2011
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7BV6
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![BU of 7bv6 by Molmil](/molmil-images/mine/7bv6) | Crystal structure of the autophagic STX17/SNAP29/VAMP8 SNARE complex | Descriptor: | Synaptosomal-associated protein 29, Syntaxin-17, Vesicle-associated membrane protein 8 | Authors: | Li, Y, Pan, L.F. | Deposit date: | 2020-04-09 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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7BV4
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![BU of 7bv4 by Molmil](/molmil-images/mine/7bv4) | Crystal structure of STX17 LIR region in complex with GABARAP | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Gamma-aminobutyric acid receptor-associated protein, ... | Authors: | Li, Y, Pan, L.F. | Deposit date: | 2020-04-09 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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5Z7L
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![BU of 5z7l by Molmil](/molmil-images/mine/5z7l) | Crystal structure of NDP52 SKICH region in complex with NAP1 | Descriptor: | 5-azacytidine-induced protein 2, Calcium-binding and coiled-coil domain-containing protein 2, GLYCEROL | Authors: | Fu, T, Pan, L.F. | Deposit date: | 2018-01-29 | Release date: | 2019-01-02 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8I2N
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![BU of 8i2n by Molmil](/molmil-images/mine/8i2n) | The RIPK1 kinase domain in complex with QY7-2B compound | Descriptor: | Receptor-interacting serine/threonine-protein kinase 1, ~{N}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide | Authors: | Gong, X.Y, Li, Y, Meng, H.Y, Pan, L.F. | Deposit date: | 2023-01-14 | Release date: | 2024-01-31 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Acta Pharm Sin B, 14, 2024
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8JC5
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![BU of 8jc5 by Molmil](/molmil-images/mine/8jc5) | |
8JCA
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8H3T
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![BU of 8h3t by Molmil](/molmil-images/mine/8h3t) | The crystal structure of AlpH | Descriptor: | AlpH, GLYCEROL | Authors: | Zhao, Y, Li, M, Jiang, M, Pan, L.F. | Deposit date: | 2022-10-09 | Release date: | 2023-09-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.866 Å) | Cite: | O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis. Nat Commun, 14, 2023
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7X81
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![BU of 7x81 by Molmil](/molmil-images/mine/7x81) | The crystal structure of PloI4-C16M/D46A/I137V in complex with exo-2+2 adduct | Descriptor: | (4S,4aS,6aR,8R,9R,11E,12aR,14aS,17E,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-11,12a,13,18a-tetramethyl-2,3,4,4a,6a,7,8,9,10,12a,13,14,18a,18b-tetradecahydro-14a,17-(metheno)cyclobuta[b]naphtho[2,1-j][1]azacyclotetradecine-16,18(1H,15H)-dione, PloI4 | Authors: | Li, M, Pan, L.F. | Deposit date: | 2022-03-10 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nat.Chem., 15, 2023
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7X80
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7X7Z
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7X86
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![BU of 7x86 by Molmil](/molmil-images/mine/7x86) | The crystal structure of PloI4-F124L in complex with endo-4+2 adduct | Descriptor: | (4S,4aS,6aR,8R,9R,10aS,13S,14aS,18aR,18bR,E)-9-ethyl-4,8,19-trihydroxy-10a,12,13,18a-tetramethyl-2,3,4,4a,6a,7,8,9,10,10a,13,14,18a,18b-tetradecahydro-14a,17-(metheno)benzo[b]naphtho[2,1-h][1]azacyclododecine-16,18(1H,15H)-dione, PloI4 | Authors: | Li, M, Pan, L.F. | Deposit date: | 2022-03-11 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.303 Å) | Cite: | A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nat.Chem., 15, 2023
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7XFR
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7YJ0
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7D0E
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![BU of 7d0e by Molmil](/molmil-images/mine/7d0e) | Crystal structure of FIP200 Claw/p-CCPG1 FIR2 | Descriptor: | 3-(2-hydroxyethyloxy)-2-[2-(2-hydroxyethyloxy)ethoxymethyl]-2-(2-hydroxyethyloxymethyl)propan-1-ol, Cell cycle progression protein 1 FIR2, DI(HYDROXYETHYL)ETHER, ... | Authors: | Zhou, Z.X, Pan, L.F. | Deposit date: | 2020-09-09 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
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7CZG
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![BU of 7czg by Molmil](/molmil-images/mine/7czg) | Crystal structure of FIP200 Claw domain apo form | Descriptor: | DI(HYDROXYETHYL)ETHER, RB1-inducible coiled-coil protein 1 | Authors: | Zhou, Z.X, Pan, L.F. | Deposit date: | 2020-09-08 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
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