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PDB: 527 件

4OD1
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Crystal structure of human Fab CAP256-VRC26.03, a potent V1V2-directed HIV-1 neutralizing antibody
分子名称: CAP256-VRC26.03 heavy chain, CAP256-VRC26.03 light chain
著者Gorman, J, Doria-Rose, N.A, Schramm, C.A, Moore, P.L, Mascola, J.R, Shapiro, L, Morris, L, Kwong, P.D.
登録日2014-01-09
公開日2014-02-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nature, 509, 2014
4OGV
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Co-Crystal Structure of MDM2 with Inhibitor Compound 49
分子名称: E3 ubiquitin-protein ligase Mdm2, [(2S,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid
著者Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
登録日2014-01-16
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.197 Å)
主引用文献Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4OGN
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Co-Crystal Structure of MDM2 with Inhbitor Compound 3
分子名称: 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
著者Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
登録日2014-01-16
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.377 Å)
主引用文献Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4OGT
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Co-Crystal Structure of MDM2 with Inhbitor Compound 46
分子名称: 6-{[(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
著者Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
登録日2014-01-16
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5361 Å)
主引用文献Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4O8V
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O-Acetyltransferase Domain of Pseudomonas putida AlgJ
分子名称: Alginate biosynthesis protein AlgJ
著者Ricer, T, Little, D.J, Whitney, J.C, Robinson, H, Howell, P.L.
登録日2013-12-30
公開日2014-10-01
実験手法X-RAY DIFFRACTION (1.815 Å)
主引用文献P. aeruginosa SGNH Hydrolase-Like Proteins AlgJ and AlgX Have Similar Topology but Separate and Distinct Roles in Alginate Acetylation.
Plos Pathog., 10, 2014
4OBA
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Co-crystal structure of MDM2 with Inhibitor Compound 4
分子名称: E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid
著者Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
登録日2014-01-07
公開日2014-03-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction.
J.Med.Chem., 57, 2014
4OCR
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Crystal structure of human Fab CAP256-VRC26.01, a potent V1V2-directed HIV-1 neutralizing antibody
分子名称: CAP256-VRC26.01 heavy chain, CAP256-VRC26.01 light chain
著者Gorman, J, Doria-Rose, N.A, Schramm, C.A, Moore, P.L, Mascola, J.R, Shapiro, L, Morris, L, Kwong, P.D.
登録日2014-01-09
公開日2014-02-26
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.895 Å)
主引用文献Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nature, 509, 2014
4ODF
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BU of 4odf by Molmil
Co-Crystal Structure of MDM2 with Inhibitor Compound 47
分子名称: 6-{[(2S,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2
著者Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
登録日2014-01-10
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2006 Å)
主引用文献Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4NK8
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Crystal Structure of the periplasmic alginate epimerase AlgG D317A mutant
分子名称: Poly(beta-D-mannuronate) C5 epimerase
著者Howell, P.L, Wolfram, F, Robinson, H.
登録日2013-11-12
公開日2014-01-15
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.2924 Å)
主引用文献Catalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgG.
J.Biol.Chem., 289, 2014
4P7O
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Structure of Escherichia coli PgaB C-terminal domain, P1 crystal form
分子名称: Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase
著者Little, D.J, Li, G, Ing, C, DiFrancesco, B, Bamford, N.C, Robinson, H, Nitz, M, Pomes, R, Howell, P.L.
登録日2014-03-27
公開日2014-07-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Modification and periplasmic translocation of the biofilm exopolysaccharide poly-beta-1,6-N-acetyl-D-glucosamine.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P99
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Ca2+-stabilized adhesin helps an Antarctic bacterium reach out and bind ice
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
著者Guo, S, Vance, D.R.T, Campbell, R.L, Davies, P.L.
登録日2014-04-02
公開日2014-06-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Ca2+-stabilized adhesin helps an Antarctic bacterium reach out and bind ice.
Biosci.Rep., 34, 2014
4P7Q
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Structure of Escherichia coli PgaB C-terminal domain in complex with N-acetylglucosamine
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase
著者Little, D.J, Li, G, Ing, C, DiFrancesco, B, Bamford, N.C, Robinson, H, Nitz, M, Pomes, R, Howell, P.L.
登録日2014-03-27
公開日2014-07-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献Modification and periplasmic translocation of the biofilm exopolysaccharide poly-beta-1,6-N-acetyl-D-glucosamine.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P7R
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BU of 4p7r by Molmil
Structure of Escherichia coli PgaB C-terminal domain in complex with a poly-beta-1,6-N-acetyl-D-glucosamine (PNAG) hexamer
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase
著者Little, D.J, Li, G, Ing, C, DiFrancesco, B, Bamford, N.C, Robinson, H, Nitz, M, Pomes, R, Howell, P.L.
登録日2014-03-27
公開日2014-07-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Modification and periplasmic translocation of the biofilm exopolysaccharide poly-beta-1,6-N-acetyl-D-glucosamine.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P7N
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BU of 4p7n by Molmil
Structure of Escherichia coli PgaB C-terminal domain in complex with glucosamine
分子名称: 2-amino-2-deoxy-beta-D-glucopyranose, Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase
著者Little, D.J, Li, G, Ing, C, DiFrancesco, B, Bamford, N.C, Robinson, H, Nitz, M, Pomes, R, Howell, P.L.
登録日2014-03-27
公開日2014-07-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Modification and periplasmic translocation of the biofilm exopolysaccharide poly-beta-1,6-N-acetyl-D-glucosamine.
Proc.Natl.Acad.Sci.USA, 111, 2014
1HY1
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BU of 1hy1 by Molmil
CRYSTAL STRUCTURE OF WILD TYPE DUCK DELTA 2 CRYSTALLIN (EYE LENS PROTEIN)
分子名称: DELTA CRYSTALLIN II
著者Sampaleanu, L.M, Vallee, F, Slingsby, C, Howell, P.L.
登録日2001-01-17
公開日2001-04-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis.
Biochemistry, 40, 2001
1I0A
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BU of 1i0a by Molmil
CRYSTAL STRUCTURE OF WILD TYPE TURKEY DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)
分子名称: DELTA CRYSTALLIN I
著者Sampaleanu, L.M, Vallee, F, Slingsby, C, Howell, P.L.
登録日2001-01-29
公開日2001-04-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis.
Biochemistry, 40, 2001
1JAB
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TYPE III ANTIFREEZE PROTEIN ISOFORM HPLC 12 T18S
分子名称: PROTEIN (ANTIFREEZE PROTEIN TYPE III)
著者Graether, S.P, Deluca, C.I, Baardsnes, J, Hill, G.A, Davies, P.L, Jia, Z.
登録日1999-01-24
公開日1999-04-29
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Quantitative and qualitative analysis of type III antifreeze protein structure and function.
J.Biol.Chem., 274, 1999
1K62
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Crystal Structure of the Human Argininosuccinate Lyase Q286R Mutant
分子名称: Argininosuccinate Lyase
著者Sampaleanu, L.M, Vallee, F, Thompson, G.D, Howell, P.L.
登録日2001-10-14
公開日2002-02-01
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R.
Biochemistry, 40, 2001
1KB4
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Crystal Structure of VDR DNA-binding Domain Bound to a Canonical Direct Repeat with Three Base Pair Spacer (DR3) Response Element
分子名称: 5'-D(*CP*AP*CP*AP*GP*GP*TP*CP*AP*CP*GP*AP*AP*GP*GP*TP*CP*A)-3', 5'-D(*TP*GP*AP*CP*CP*TP*TP*CP*GP*TP*GP*AP*CP*CP*TP*GP*TP*G)-3', Vitamin D3 Receptor, ...
著者Shaffer, P.L, Gewirth, D.T.
登録日2001-11-05
公開日2002-05-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
1KB6
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Crystal Structure of VDR DNA-binding Domain Bound to Rat Osteocalcin (OC) Response Element
分子名称: 5'-D(*CP*AP*CP*GP*GP*GP*TP*GP*AP*AP*TP*GP*AP*GP*GP*AP*CP*A)-3', 5'-D(*TP*GP*TP*CP*CP*TP*CP*AP*TP*TP*CP*AP*CP*CP*CP*GP*TP*G)-3', Vitamin D3 Receptor, ...
著者Shaffer, P.L, Gewirth, D.T.
登録日2001-11-05
公開日2002-05-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
1KB2
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BU of 1kb2 by Molmil
Crystal Structure of VDR DNA-binding Domain Bound to Mouse Osteopontin (SPP) Response Element
分子名称: 5'-D(*CP*AP*CP*GP*GP*TP*TP*CP*AP*CP*GP*AP*GP*GP*TP*TP*CP*A)-3', 5'-D(*TP*GP*AP*AP*CP*CP*TP*CP*GP*TP*GP*AP*AP*CP*CP*GP*TP*G)-3', Vitamin D3 Receptor, ...
著者Shaffer, P.L, Gewirth, D.T.
登録日2001-11-05
公開日2002-05-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis of VDR-DNA interactions on direct repeat response elements.
EMBO J., 21, 2002
1K97
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Crystal Structure of E. coli Argininosuccinate Synthetase in complex with Aspartate and Citrulline
分子名称: ARGININOSUCCINATE SYNTHASE, ASPARTIC ACID, CITRULLINE
著者Lemke, C.T, Howell, P.L.
登録日2001-10-26
公開日2001-12-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The 1.6 A crystal structure of E. coli argininosuccinate synthetase suggests a conformational change during catalysis.
Structure, 9, 2001
1KKT
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Structure of P. citrinum alpha 1,2-mannosidase reveals the basis for differences in specificity of the ER and Golgi Class I enzymes
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannosyl-oligosaccharide alpha-1,2-mannosidase, ...
著者Lobsanov, Y.D, Vallee, F, Imberty, A, Yoshida, T, Yip, P, Herscovics, A, Howell, P.L.
登録日2001-12-10
公開日2002-01-23
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Penicillium citrinum alpha 1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymes.
J.Biol.Chem., 277, 2002
1I6G
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NMR SOLUTION STRUCTURE OF THE INSECT-SPECIFIC NEUROTOXIN VARIANT 5 (CSE-V5) FROM THE SCORPION CENTRUROIDES SCULPTURATUS EWING
分子名称: NEUROTOXIN V-5
著者Jablonsky, M.J, Jackson, P.L, Krishna, N.R.
登録日2001-03-02
公開日2001-08-01
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Solution structure of an insect-specific neurotoxin from the New World scorpion Centruroides sculpturatus Ewing.
Biochemistry, 40, 2001
1KP2
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Crystal Structure of E. coli Argininosuccinate Synthetase in Complex with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANIDINE, PHOSPHATE ION, ...
著者Lemke, C.T, Howell, P.L.
登録日2001-12-27
公開日2002-04-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Substrate Induced Conformational Changes in Argininosuccinate Synthetase
J.Biol.Chem., 277, 2002

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