5NYV
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![BU of 5nyv by Molmil](/molmil-images/mine/5nyv) | Crystal structure determination from picosecond infrared laser ablated protein crystals by serial synchrotron crystallography | Descriptor: | Fluoroacetate dehalogenase | Authors: | Schulz, E.C, Kaub, J, Busse, F, Mehrabi, P, Mueller-Werkmeiser, H, Pai, E.F, Robertson, W.D, Miller, R.J.D. | Deposit date: | 2017-05-11 | Release date: | 2018-03-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Protein crystals IR laser ablated from aqueous solution at high speed retain their diffractive properties: applications in high-speed serial crystallography. J.Appl.Crystallogr., 50, 2017
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2XA7
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![BU of 2xa7 by Molmil](/molmil-images/mine/2xa7) | AP2 clathrin adaptor core in active complex with cargo peptides | Descriptor: | ADAPTOR-RELATED PROTEIN COMPLEX 2, ALPHA 2 SUBUNIT, AP-2 COMPLEX SUBUNIT BETA, ... | Authors: | Jackson, L.P, Kelly, B.T, McCoy, A.J, Evans, P.R, Owen, D.J. | Deposit date: | 2010-03-29 | Release date: | 2010-07-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A Large Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the Ap2 Clathrin Adaptor Complex Cell(Cambridge,Mass.), 141, 2010
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8AKO
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![BU of 8ako by Molmil](/molmil-images/mine/8ako) | Structure of EspB-EspK complex: the non-identical twin of the PE-PPE-EspG secretion mechanism. | Descriptor: | ESX-1 secretion-associated protein EspB, ESX-1 secretion-associated protein EspK | Authors: | Gijsbers, A, Eymery, M, Menart, I, Vinciauskaite, V, Gao, Y, Siliqi, D, Peters, P, Mccarthy, A, Ravelli, R.B.G. | Deposit date: | 2022-07-30 | Release date: | 2022-12-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.293 Å) | Cite: | The crystal structure of the EspB-EspK virulence factor-chaperone complex suggests an additional type VII secretion mechanism in Mycobacterium tuberculosis. J.Biol.Chem., 299, 2022
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1N5C
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![BU of 1n5c by Molmil](/molmil-images/mine/1n5c) | Crystal Structure Analysis of the B-DNA Dodecamer CGCGAATT(ethenoC)GCG | Descriptor: | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(EDC)P*GP*CP*G)-3', SODIUM ION | Authors: | Freisinger, E, Fernandes, A, Grollman, A.P, Kisker, C.F. | Deposit date: | 2002-11-05 | Release date: | 2003-06-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystallographic Characterization of an Exocyclic DNA Adduct: 3,N4-etheno-2'-deoxycytidine in the Dodecamer 5'-CGCGAATT(ethenoC)GCG-3' J.Mol.Biol., 329, 2003
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3V49
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![BU of 3v49 by Molmil](/molmil-images/mine/3v49) | Structure of ar lbd with activator peptide and sarm inhibitor 1 | Descriptor: | 4-[(4R)-4-(4-hydroxyphenyl)-3,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile, Androgen receptor, activator peptide, ... | Authors: | Nique, F, Hebbe, S, Peixoto, C, Annoot, D, Lefrancois, J.-M, Duval, E, Michoux, L, Triballeau, N, Lemoullec, J.-M, Mollat, P, Thauvin, M, Prange, T, Minet, D, Clement-Lacroix, P, Robin-Jagerschmidt, C, Fleury, D, Guedin, D, Deprez, P. | Deposit date: | 2011-12-14 | Release date: | 2012-09-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of diarylhydantoins as new selective androgen receptor modulators. J.Med.Chem., 55, 2012
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1HHL
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1GRH
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![BU of 1grh by Molmil](/molmil-images/mine/1grh) | INHIBITION OF HUMAN GLUTATHIONE REDUCTASE BY THE NITROSOUREA DRUGS 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA AND 1-(2-CHLOROETHYL)-3-(2-HYDROXYETHYL)-1-NITROSOUREA | Descriptor: | ETHANOL, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE REDUCTASE, ... | Authors: | Karplus, P.A, Schulz, G.E. | Deposit date: | 1992-12-15 | Release date: | 1994-01-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis. Eur.J.Biochem., 171, 1988
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5V6Q
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![BU of 5v6q by Molmil](/molmil-images/mine/5v6q) | Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc04462 (SmGhrB) from Sinorhizobium meliloti in complex with NADP and malonate | Descriptor: | MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH-dependent glyoxylate/hydroxypyruvate reductase, ... | Authors: | Shabalin, I.G, Handing, K.B, Miezaniec, A.P, Gasiorowska, O.A, Bonanno, J, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2017-03-17 | Release date: | 2017-03-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies. Biochemistry, 57, 2018
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8SRZ
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5O1O
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![BU of 5o1o by Molmil](/molmil-images/mine/5o1o) | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with proline bound. | Descriptor: | 1,2-ETHANEDIOL, Alpha-aminoadipic semialdehyde synthase, mitochondrial, ... | Authors: | Kopec, J, Rembeza, E, Pena, I.A, Mathea, S, Velupillai, S, Strain-Damerell, C, Goubin, S, Kupinska, K, Talon, R, Collins, P, Krojer, T, Burgess-Brown, N, Arrowsmith, C, Edwards, A, Bountra, C, von Delft, F, Arruda, P, Yue, W.W. | Deposit date: | 2017-05-18 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with proline bound. To Be Published
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8ACH
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![BU of 8ach by Molmil](/molmil-images/mine/8ach) | Nudaurelia capensis omega virus maturation intermediate captured at pH5.6 (insect cell expressed VLPs): large class from symmetry expansion | Descriptor: | p70 | Authors: | Castells-Graells, R, Hesketh, E.L, Johnson, J.E, Ranson, N.A, Lawson, D.M, Lomonossoff, G.P. | Deposit date: | 2022-07-05 | Release date: | 2022-12-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.91 Å) | Cite: | Decoding virus maturation with cryo-EM structures of intermediates To be published
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1I16
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![BU of 1i16 by Molmil](/molmil-images/mine/1i16) | STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES | Descriptor: | INTERLEUKIN 16 | Authors: | Muehlhahn, P, Zweckstetter, M, Georgescu, J, Ciosto, C, Renner, C, Lanzendoerfer, M, Lang, K, Ambrosius, D, Baier, M, Kurth, R, Holak, T.A. | Deposit date: | 1998-05-20 | Release date: | 1999-05-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site. Nat.Struct.Biol., 5, 1998
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8AC6
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![BU of 8ac6 by Molmil](/molmil-images/mine/8ac6) | Nudaurelia capensis omega virus maturation intermediate captured at pH5.6 (insect cell expressed VLPs): medium class from symmetry expansion | Descriptor: | p70 | Authors: | Castells-Graells, R, Hesketh, E.L, Johnson, J.E, Ranson, N.A, Lawson, D.M, Lomonossoff, G.P. | Deposit date: | 2022-07-05 | Release date: | 2022-12-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Decoding virus maturation with cryo-EM structures of intermediates To be published
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5O2G
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![BU of 5o2g by Molmil](/molmil-images/mine/5o2g) | Crystal structure determination from picosecond infrared laser ablated protein crystals by serial synchrotron crystallography | Descriptor: | Fluoroacetate dehalogenase | Authors: | Schulz, E.C, Kaub, J, Busse, F, Mehrabi, P, Mueller-Werkmeiser, H, Pai, E.F, Robertson, W.D, Miller, R.J.D. | Deposit date: | 2017-05-20 | Release date: | 2018-05-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure determination from picosecond infrared laser ablated protein crystals by serial synchrotron crystallography To Be Published
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6M7K
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![BU of 6m7k by Molmil](/molmil-images/mine/6m7k) | Structure of mouse RECON (AKR1C13) in complex with cyclic AMP-AMP-GMP (cAAG) | Descriptor: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C13, cyclic AMP-AMP-GMP | Authors: | Eaglesham, J.B, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Nieminen, E.A, King, D.S, Lee, A.S.Y, Mekalanos, J.J, Kranzusch, P.J. | Deposit date: | 2018-08-20 | Release date: | 2019-02-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature, 567, 2019
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3Q8M
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![BU of 3q8m by Molmil](/molmil-images/mine/3q8m) | Crystal Structure of Human Flap Endonuclease FEN1 (D181A) in complex with substrate 5'-flap DNA and K+ | Descriptor: | DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... | Authors: | Tsutakawa, S.E, Classen, S, Chapados, B.R, Arvai, A, Finger, D.L, Guenther, G, Tomlinson, C.G, Thompson, P, Sarker, A.H, Shen, B, Cooper, P.K, Grasby, J.A, Tainer, J.A. | Deposit date: | 2011-01-06 | Release date: | 2011-04-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily. Cell(Cambridge,Mass.), 145, 2011
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4DYH
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![BU of 4dyh by Molmil](/molmil-images/mine/4dyh) | Crystal structure of glycosylated Lipase from Humicola lanuginosa at 2 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Lipase | Authors: | Singh, A, Mukherjee, J, Gupta, M.N, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2012-02-29 | Release date: | 2012-04-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of glycosylated Lipase from Humicola lanuginosa at 2 Angstrom resolution TO BE PUBLISHED
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8AAY
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![BU of 8aay by Molmil](/molmil-images/mine/8aay) | Nudaurelia capensis omega virus maturation intermediate captured at pH5.6 (insect cell expressed VLPs): small class from symmetry expansion | Descriptor: | p70 | Authors: | Castells-Graells, R, Hesketh, E.L, Johnson, J.E, Ranson, N.A, Lawson, D.M, Lomonossoff, G.P. | Deposit date: | 2022-07-04 | Release date: | 2022-12-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Decoding virus maturation with cryo-EM structures of intermediates To be published
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2WKL
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![BU of 2wkl by Molmil](/molmil-images/mine/2wkl) | Velaglucerase alfa | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUCOSYLCERAMIDASE, ... | Authors: | Brumshtein, B, Salinas, P, Peterson, B, Chan, V, Silman, I, Sussman, J.L, Savickas, P.J, Robinson, G.S, Futerman, A.H. | Deposit date: | 2009-06-15 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Characterization of Gene-Activated Human Acid-Beta-Glucosidase: Crystal Structure, Glycan Composition and Internalization Into Macrophages. Glycobiology, 20, 2010
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5O4W
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![BU of 5o4w by Molmil](/molmil-images/mine/5o4w) | Protein structure determination by electron diffraction using a single three-dimensional nanocrystal | Descriptor: | Lysozyme C | Authors: | Clabbers, M.T.B, van Genderen, E, Wan, W, Wiegers, E.L, Gruene, T, Abrahams, J.P. | Deposit date: | 2017-05-31 | Release date: | 2017-08-23 | Last modified: | 2024-01-17 | Method: | ELECTRON CRYSTALLOGRAPHY (2.11 Å) | Cite: | Protein structure determination by electron diffraction using a single three-dimensional nanocrystal. Acta Crystallogr D Struct Biol, 73, 2017
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4I9V
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![BU of 4i9v by Molmil](/molmil-images/mine/4i9v) | The atomic structure of 5-Hydroxymethyl 2'-deoxycitidine base paired with 2'-deoxyguanosine in Dickerson Drew Dodecamer | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(5HC)P*GP*CP*G)-3'), MAGNESIUM ION, SPERMINE (FULLY PROTONATED FORM) | Authors: | Nocek, B, Szulik, M.W, Joachimiak, A, Stone, M.P. | Deposit date: | 2012-12-05 | Release date: | 2013-11-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | Differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine. Biochemistry, 54, 2015
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1PXK
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![BU of 1pxk by Molmil](/molmil-images/mine/1pxk) | HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-Dimethyl-thiazol-5-yl)pyrimidin-2-yl]-N'-hydroxyiminoformamide | Descriptor: | Cell division protein kinase 2, N-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-N'-HYDROXYIMIDOFORMAMIDE | Authors: | Wu, S.Y, McNae, I, Kontopidis, G, McClue, S.J, McInnes, C, Stewart, K.J, Wang, S, Zheleva, D.I, Marriage, H, Lane, D.P, Taylor, P, Fischer, P.M, Walkinshaw, M.D. | Deposit date: | 2003-07-04 | Release date: | 2003-12-09 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop Structure, 11, 2003
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1HCW
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1PXQ
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![BU of 1pxq by Molmil](/molmil-images/mine/1pxq) | Structure of Subtilisin A | Descriptor: | Subtilisin A | Authors: | Kawulka, K.E, Sprules, T, McKay, R.T, Mercier, P, Diaper, C.M, Zuber, P, Vederas, J.C. | Deposit date: | 2003-07-04 | Release date: | 2004-06-22 | Last modified: | 2011-10-05 | Method: | SOLUTION NMR | Cite: | Structure of subtilisin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives Biochemistry, 43, 2004
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5O8B
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![BU of 5o8b by Molmil](/molmil-images/mine/5o8b) | Difference-refined excited-state structure of rsEGFP2 1ps following 400nm-laser irradiation of the off-state. | Descriptor: | Green fluorescent protein | Authors: | Coquelle, N, Sliwa, M, Woodhouse, J, Schiro, G, Adam, V, Aquila, A, Barends, T.R.M, Boutet, S, Byrdin, M, Carbajo, S, De la Mora, E, Doak, R.B, Feliks, M, Fieschi, F, Foucar, L, Guillon, V, Hilpert, M, Hunter, M, Jakobs, S, Koglin, J.E, Kovacsova, G, Lane, T.J, Levy, B, Liang, M, Nass, K, Ridard, J, Robinson, J.S, Roome, C.M, Ruckebusch, C, Seaberg, M, Thepaut, M, Cammarata, M, Demachy, I, Field, M, Shoeman, R.L, Bourgeois, D, Colletier, J.P, Schlichting, I, Weik, M. | Deposit date: | 2017-06-12 | Release date: | 2018-01-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Chromophore twisting in the excited state of a photoswitchable fluorescent protein captured by time-resolved serial femtosecond crystallography. Nat Chem, 10, 2018
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