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PDB: 472 results

8AV4
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BU of 8av4 by Molmil
Small molecular stabilizer for ERalpha and 14-3-3 (1075305)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[4-(4-chloranylphenoxy)oxan-4-yl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-08-26
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023
8ALV
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BU of 8alv by Molmil
Small molecular stabilizer for ERalpha and 14-3-3 (1076403)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-N-[[1-[1-[(4-chlorophenyl)amino]cyclohexyl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-08-01
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023
8AI0
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BU of 8ai0 by Molmil
Small molecular stabilizer for ERalpha and 14-3-3sigma (1080268)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-N-[[1-(2-methyl-2-phenylazanyl-propanoyl)piperidin-4-yl]methyl]ethanamide, Estrogen receptor, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-07-25
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023
8ARX
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BU of 8arx by Molmil
Small molecular stabilizer for ERalpha and 14-3-3sigma (1074378)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-N-[[1-[1-(4-chloranylphenoxy)cyclopropyl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-08-17
Release date:2023-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments.
J.Am.Chem.Soc., 145, 2023
8C3Z
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BU of 8c3z by Molmil
14-3-3sigma bound to strep-tagged PKA-responsive ERa phosphopeptide
Descriptor: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION
Authors:Somsen, B.A, Ottmann, C.
Deposit date:2022-12-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex.
J.Biol.Chem., 299, 2023
8BYE
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BU of 8bye by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1075313)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclobutane-1-carboxamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-12
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BYB
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BU of 8byb by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074398)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-12
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BWZ
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BU of 8bwz by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-07
Release date:2023-08-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BWJ
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BU of 8bwj by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074386)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-2-[4-(trifluoromethyl)phenoxy]propanamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-06
Release date:2023-08-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BYF
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BU of 8byf by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1047455)
Descriptor: 14-3-3 protein sigma, PHE-PRO-ALA-TPO-VAL, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-chloranylphenoxy)-2-methyl-propanamide
Authors:Visser, E.J, Sijbesma, E, Ottmann, C.
Deposit date:2022-12-12
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BX4
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BU of 8bx4 by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074392)
Descriptor: 14-3-3 protein sigma, 2-[3,4-bis(chloranyl)phenoxy]-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-07
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BXS
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BU of 8bxs by Molmil
Fragment-linked stabilizer for ERa - 14-3-3 interaction (1075293)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-(4-chloranylphenoxy)oxane-4-carboxamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-09
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BXO
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BU of 8bxo by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1075287)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4,4-bis(fluoranyl)-1-phenoxy-cyclohexane-1-carboxamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-09
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BXI
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BU of 8bxi by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-08
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BXQ
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BU of 8bxq by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1075296)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-phenoxy-cyclohexane-1-carboxamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-09
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BY9
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BU of 8by9 by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1075292)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)-4,4-bis(fluoranyl)cyclohexane-1-carboxamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-12
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BYD
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BU of 8byd by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interactions (1075288)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclopentane-1-carboxamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-12
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BX3
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BU of 8bx3 by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074372)
Descriptor: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-07
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BWX
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BU of 8bwx by Molmil
Fragment-linked stabilizer for 14-3-3 and ERa (1075298)
Descriptor: 14-3-3 protein sigma, 4-azanyl-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide, ERalpha peptide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-07
Release date:2023-08-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BXN
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BU of 8bxn by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074399)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-phenoxy-oxane-4-carboxamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-09
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BYC
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BU of 8byc by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1075316)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-12
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BX0
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BU of 8bx0 by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074388)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-methoxyphenoxy)-2-methyl-propanamide
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-07
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BXM
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BU of 8bxm by Molmil
fragment-linked stabilizer for ERa - 14-3-3 interaction (1074397)
Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ...
Authors:Visser, E.J, Vandenboorn, E.M.F, Ottmann, C.
Deposit date:2022-12-09
Release date:2023-08-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BWH
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BU of 8bwh by Molmil
Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42)
Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ...
Authors:Pennings, M.A.M, Visser, E.J, Ottmann, C.
Deposit date:2022-12-06
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.
Biorxiv, 2024
8BWE
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BU of 8bwe by Molmil
Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43)
Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ...
Authors:Visser, E.J, Pennings, M.A.M, Ottmann, C.
Deposit date:2022-12-06
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.
Biorxiv, 2024

222926

数据于2024-07-24公开中

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