6WCA
 
 | | Human closed state TMEM175 in KCl | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Paknejad, N, Hite, R.K. | | Deposit date: | 2020-03-30 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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6WC9
 | | Human open state TMEM175 in KCl | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Paknejad, N, Hite, R.K. | | Deposit date: | 2020-03-30 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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6WCB
 | | Human open state TMEM175 in CsCl | | Descriptor: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | | Authors: | Oh, S, Paknejad, N, Hite, R.K. | | Deposit date: | 2020-03-30 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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6WCC
 | | Human closed state TMEM175 in CsCl | | Descriptor: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | | Authors: | Oh, S, Paknejad, N, Hite, R.K. | | Deposit date: | 2020-03-30 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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8VIC
 | | AP-6 bound human TMEM175 | | Descriptor: | (2P,2'P)-2,2'-(1,3-phenylene)di(pyridin-4-amine), Endosomal/lysosomal potassium channel TMEM175 | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2024-01-03 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structure of human TMEM175 in an inhibitor-bound state
To Be Published
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8VIE
 | | 2-PPA bound human TMEM175 | | Descriptor: | 2-phenylpyridin-4-amine, Endosomal/lysosomal potassium channel TMEM175 | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structure of human TMEM175 in an inhibitor-bound state
To Be Published
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7UNM
 | | Human TMEM175 in an closed state | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2022-04-11 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175.
Elife, 11, 2022
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7UNL
 | | Human TMEM175 in an open state | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2022-04-11 | | Release date: | 2022-06-01 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175.
Elife, 11, 2022
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8DHM
 | | Human TMEM175 in complex with 4-aminopyridine | | Descriptor: | 4-AMINOPYRIDINE, Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2022-06-27 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6CTF
 | | Crystal structure of GltPh fast mutant - R276S/M395R | | Descriptor: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | | Authors: | Boudker, O, Oh, S. | | Deposit date: | 2018-03-23 | | Release date: | 2018-10-10 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (4.05 Å) | | Cite: | Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh.
Elife, 7, 2018
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5UZ6
 | | RNA hairpin structure containing 2-MeImp-oligo analogue | | Descriptor: | RNA (25-MER), RNA (5'-D(*(8OS))-R(P*CP*AP*CP*CP*UP*CP*A)-3') | | Authors: | Zhang, W, Oh, S.S, Szostak, J.W. | | Deposit date: | 2017-02-24 | | Release date: | 2018-02-21 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide.
J. Am. Chem. Soc., 140, 2018
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5UX3
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5CFY
 | | CRYSTAL STRUCTURE OF GLTPH R397A IN COMPLEX WITH NA+ AND L-ASP | | Descriptor: | 425aa long hypothetical proton glutamate symport protein, ASPARTIC ACID, SODIUM ION | | Authors: | Boudker, O, Oh, S. | | Deposit date: | 2015-07-08 | | Release date: | 2016-04-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Elife, 3, 2014
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4OYE
 | | Crystal structure of GltPh R397A in apo | | Descriptor: | 425aa long hypothetical proton glutamate symport protein | | Authors: | Boudker, O, Oh, S. | | Deposit date: | 2014-02-11 | | Release date: | 2014-09-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Elife, 3, 2014
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4OYF
 | | Crystal structure of GLTPH R397A IN Sodium-bound state | | Descriptor: | GLUTAMATE SYMPORT PROTEIN, SODIUM ION | | Authors: | Boudker, O, Oh, S, Verdon, G, Serio, R. | | Deposit date: | 2014-02-11 | | Release date: | 2014-08-13 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Elife, 3, 2014
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