6L6K
| Crystal structure of dimeric RXRalpha-LBD complexed with partial agonist CBt-PMN and SRC1 | 分子名称: | 1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzotriazole-5-carboxylic acid, CALCIUM ION, Nuclear receptor coactivator 1, ... | 著者 | Shimizu, K, Numoto, N, Nakano, S, Makishima, M, Kakuta, H, Ito, N. | 登録日 | 2019-10-29 | 公開日 | 2020-11-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of dimeric RXRalpha-LBD complexed with partial agonist CBt-PMN and SRC1 To Be Published
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5JX0
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6LB4
| Crystal structure of dimeric RXR-LBD complexed with NEt-3ME and TIF2 co-activator | 分子名称: | 1,2-ETHANEDIOL, 6-[ethyl-[3-(2-methoxyethoxy)-4-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid, Nuclear receptor coactivator 2, ... | 著者 | Imai, D, Numoto, N, Nakano, S, Kakuta, H, Ito, N. | 登録日 | 2019-11-13 | 公開日 | 2020-11-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of dimeric RXR-LBD complexed with NEt-3ME and TIF2 co-activator To Be Published
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6LB6
| Crystal structure of dimeric RXR-LBD complexed with partial agonist NEt-4IB and TIF2 co-activator | 分子名称: | 6-[ethyl-[4-(2-methylpropoxy)-3-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | 著者 | Imai, D, Numoto, N, Nakano, S, Kakuta, H, Ito, N. | 登録日 | 2019-11-13 | 公開日 | 2020-11-18 | 最終更新日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for the full and partial agonist activities of retinoid X receptor alpha ligands with an iso-butoxy and an isopropyl group Biochem.Biophys.Res.Commun., 734, 2024
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2E3N
| Crystal structure of CERT START domain in complex with C6-ceramide (P212121) | 分子名称: | Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)HEXANAMIDE | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | 登録日 | 2006-11-28 | 公開日 | 2007-12-18 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc.Natl.Acad.Sci.Usa, 105, 2008
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5KER
| Deer mouse recombinant hemoglobin from high altitude species | 分子名称: | Alpha-globin, Beta globin, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Inoguchi, N, Natarajan, C, Storz, J.F, Moriyama, H. | 登録日 | 2016-06-10 | 公開日 | 2017-04-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | Alteration of the alpha 1 beta 2/ alpha 2 beta 1 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice. PLoS ONE, 12, 2017
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2E3R
| Crystal structure of CERT START domain in complex with C18-ceramide (P1) | 分子名称: | Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | 登録日 | 2006-11-28 | 公開日 | 2007-12-18 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc.Natl.Acad.Sci.Usa, 105, 2008
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7OVC
| Structure of the human UFC1 protein in complex with the UBA5 C-terminal UFC1-binding motif. | 分子名称: | Ubiquitin-fold modifier-conjugating enzyme 1, Ubiquitin-like modifier-activating enzyme 5 | 著者 | Wesch, W, Loehr, F, Rogova, N, Doetsch, V, Rogov, V.V. | 登録日 | 2021-06-14 | 公開日 | 2021-08-04 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1. Int J Mol Sci, 22, 2021
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5K31
| Crystal structure of Human fibrillar procollagen type I C-propeptide Homo-trimer | 分子名称: | CALCIUM ION, CHLORIDE ION, Collagen alpha-1(I) chain, ... | 著者 | Sharma, U, Hulmes, D.J.S, Aghajari, N. | 登録日 | 2016-05-19 | 公開日 | 2017-03-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of homo- and heterotrimerization of collagen I. Nat Commun, 8, 2017
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2E3S
| Crystal structure of CERT START domain co-crystallized with C24-ceramide (P21) | 分子名称: | Lipid-transfer protein CERT | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | 登録日 | 2006-11-28 | 公開日 | 2007-12-18 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc.Natl.Acad.Sci.Usa, 105, 2008
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7PJF
| Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | 分子名称: | Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | 登録日 | 2021-08-24 | 公開日 | 2021-09-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.862 Å) | 主引用文献 | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
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7PJE
| Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | 分子名称: | Darpin D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | 登録日 | 2021-08-24 | 公開日 | 2021-09-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
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6KW4
| The ClassB RSC-Nucleosome Complex | 分子名称: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... | 著者 | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | 登録日 | 2019-09-06 | 公開日 | 2019-11-13 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (7.55 Å) | 主引用文献 | Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
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6LN3
| Crystal structure of adenylate kinase from an extremophilic archaeon Aeropyrum pernix with ATP and AMP | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Shibanuma, Y, Nemoto, N, Yamamoto, N, Sampei, G, Kawai, G. | 登録日 | 2019-12-28 | 公開日 | 2020-04-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of adenylate kinase from an extremophilic archaeon Aeropyrum pernix with ATP and AMP. J.Biochem., 168, 2020
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2E3O
| Crystal structure of CERT START domain in complex with C16-ceramide (P212121) | 分子名称: | DIMETHYL SULFOXIDE, Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | 登録日 | 2006-11-28 | 公開日 | 2007-12-18 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc.Natl.Acad.Sci.Usa, 105, 2008
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6LU8
| Cryo-EM structure of a human pre-60S ribosomal subunit - state A | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N. | 登録日 | 2020-01-26 | 公開日 | 2020-08-26 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat Commun, 11, 2020
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2GVF
| HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021 | 分子名称: | (6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE, Polyprotein, ZINC ION, ... | 著者 | Arasappan, A, Njoroge, F.G, Chen, K.X, Venkatraman, S, Parekh, T.N, Gu, H, Pichardo, J, Butkiewicz, N, Prongay, A, Madison, V, Girijavallabhan, V. | 登録日 | 2006-05-02 | 公開日 | 2007-01-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease. Bioorg.Med.Chem.Lett., 16, 2006
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6LSR
| Cryo-EM structure of a pre-60S ribosomal subunit - state B | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N. | 登録日 | 2020-01-20 | 公開日 | 2020-08-26 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat Commun, 11, 2020
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7ATH
| Crystal structure of UipA | 分子名称: | UipA, ZINC ION | 著者 | Bremond, N, Gallois, N, Legrand, P, Chapon, V, Arnoux, P. | 登録日 | 2020-10-30 | 公開日 | 2021-10-06 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria. Isme J, 16, 2022
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7Q1V
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7ATK
| Crystal structure of UipA in complex with Uranium | 分子名称: | URANIUM ATOM, UipA, ZINC ION | 著者 | Bremond, N, Gallois, N, Legrand, P, Chapon, V, Arnoux, P. | 登録日 | 2020-10-30 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.855 Å) | 主引用文献 | Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria. Isme J, 16, 2022
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6ME3
| XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin | 分子名称: | DI(HYDROXYETHYL)ETHER, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, OLEIC ACID, ... | 著者 | Stauch, B, Johansson, L.C, McCorvy, J.D, Patel, N, Han, G.W, Gati, C, Batyuk, A, Ishchenko, A, Brehm, W, White, T.A, Michaelian, N, Madsen, C, Zhu, L, Grant, T.D, Grandner, J.M, Olsen, R.H.J, Tribo, A.R, Weierstall, U, Roth, B.L, Katritch, V, Liu, W, Cherezov, V. | 登録日 | 2018-09-05 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis of ligand recognition at the human MT1melatonin receptor. Nature, 569, 2019
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6LSS
| Cryo-EM structure of a pre-60S ribosomal subunit - state preA | 分子名称: | 28S rRNA, 5S rRNA, 60S ribosomal protein L11, ... | 著者 | Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N. | 登録日 | 2020-01-20 | 公開日 | 2020-08-26 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat Commun, 11, 2020
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7PHZ
| Crystal structure of X77 bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 in spacegroup P2(1)2(1)2(1). | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Costanzi, E, Demitri, N, Storici, P. | 登録日 | 2021-08-19 | 公開日 | 2022-09-07 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Unexpected Single-Ligand Occupancy and Negative Cooperativity in the SARS-CoV-2 Main Protease. J.Chem.Inf.Model., 64, 2024
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6ME5
| XFEL crystal structure of human melatonin receptor MT1 in complex with agomelatine | 分子名称: | OLEIC ACID, chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, ~{N}-[2-(7-methoxynaphthalen-1-yl)ethyl]ethanamide | 著者 | Stauch, B, Johansson, L.C, McCorvy, J.D, Patel, N, Han, G.W, Gati, C, Batyuk, A, Ishchenko, A, Brehm, W, White, T.A, Michaelian, N, Madsen, C, Zhu, L, Grant, T.D, Grandner, J.M, Olsen, R.H.J, Tribo, A.R, Weierstall, U, Roth, B.L, Katritch, V, Liu, W, Cherezov, V. | 登録日 | 2018-09-05 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis of ligand recognition at the human MT1melatonin receptor. Nature, 569, 2019
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