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PDB: 151 件
6W85
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BU of 6w85 by Molmil
K2P2.1 (TREK-1):ML335 complex, 200 mM K+
分子名称: CADMIUM ION, DECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
5AE2
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BU of 5ae2 by Molmil
Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1e
分子名称: 3-(2-fluorophenyl)-2-methyl-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)acrylamide, ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, ...
著者Piano, V, Benjamin, D.I, Valente, S, Nenci, S, Marrocco, B, Mai, A, Aliverti, A, Nomura, D.K, Mattevi, A.
登録日2015-08-25
公開日2015-09-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.
Acs Chem.Biol., 10, 2015
6W7E
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BU of 6w7e by Molmil
K2P2.1 (TREK-1), 30 mM K+
分子名称: CADMIUM ION, DODECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-19
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W84
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BU of 6w84 by Molmil
K2P2.1 (TREK-1), 200 mM K+
分子名称: CADMIUM ION, DODECANE, N-OCTANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W8A
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BU of 6w8a by Molmil
K2P2.1 (TREK-1):ML335 complex, 10 mM K+
分子名称: CADMIUM ION, DODECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.002 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W8F
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BU of 6w8f by Molmil
K2P2.1 (TREK-1):ML335 complex, 0 mM K+
分子名称: CADMIUM ION, DODECANE, HEXADECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W86
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BU of 6w86 by Molmil
K2P2.1 (TREK-1):ML335 complex, 100 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.299 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W83
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BU of 6w83 by Molmil
K2P2.1 (TREK-1), 100 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.901 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
6W87
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BU of 6w87 by Molmil
K2P2.1 (TREK-1):ML335 complex, 50 mM K+
分子名称: CADMIUM ION, DECANE, DODECANE, ...
著者Lolicato, M, Minor, D.L.
登録日2020-03-20
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献K 2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Sci Adv, 6, 2020
5ADZ
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BU of 5adz by Molmil
Ether Lipid-Generating Enzyme AGPS in complex with inhibitor 1a
分子名称: (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide), ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, ...
著者Piano, V, Benjamin, D.I, Valente, S, Nenci, S, Marrocco, B, Mai, A, Aliverti, A, Nomura, D.K, Mattevi, A.
登録日2015-08-25
公開日2015-09-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.
Acs Chem.Biol., 10, 2015
6V36
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BU of 6v36 by Molmil
K2P2.1(TREK-1)I110D apo channel structure
分子名称: CADMIUM ION, N-OCTANE, POTASSIUM ION, ...
著者Pope, L, Lolicato, M, Minor, D.L.
登録日2019-11-25
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Polynuclear Ruthenium Amines Inhibit K2PChannels via a "Finger in the Dam" Mechanism.
Cell Chem Biol, 2020
6V37
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BU of 6v37 by Molmil
K2P2.1(TREK-1)I110D:RuR:ML335 bound channel structure
分子名称: CADMIUM ION, DODECANE, HEXANE, ...
著者Pope, L, Lolicato, M, Minor, D.L.
登録日2019-11-25
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Polynuclear Ruthenium Amines Inhibit K2PChannels via a "Finger in the Dam" Mechanism.
Cell Chem Biol, 2020
6V3I
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BU of 6v3i by Molmil
K2P2.1(TREK-1)I110D:RuR bound channel structure
分子名称: CADMIUM ION, DODECANE, HEXANE, ...
著者Pope, L, Lolicato, M, Minor, D.L.
登録日2019-11-25
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Polynuclear Ruthenium Amines Inhibit K2PChannels via a "Finger in the Dam" Mechanism.
Cell Chem Biol, 2020
6V3C
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BU of 6v3c by Molmil
K2P2.1(TREK-1)I110D:Ru360 bound channel structure
分子名称: CADMIUM ION, HEXANE, N-OCTANE, ...
著者Pope, L, Lolicato, M, Minor, D.L.
登録日2019-11-25
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.51 Å)
主引用文献Polynuclear Ruthenium Amines Inhibit K2PChannels via a "Finger in the Dam" Mechanism.
Cell Chem Biol, 2020
3OXQ
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BU of 3oxq by Molmil
Crystal Structure of Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex
分子名称: CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel subunit alpha-1C
著者Kim, E.Y, Rumpf, C.H, Van Petegem, F, Arant, R, Findeisen, F, Cooley, E.S, Isacoff, E.Y, Minor, D.L.
登録日2010-09-21
公開日2010-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.
Embo J., 29, 2010
3OX6
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BU of 3ox6 by Molmil
Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)
分子名称: CALCIUM ION, Calcium-binding protein 1, HEXANE-1,6-DIOL
著者Findeisen, F, Minor, D.L.
登録日2010-09-21
公開日2010-12-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis for the Differential Effects of CaBP1 and Calmodulin on Ca(V)1.2 Calcium-Dependent Inactivation.
Structure, 18, 2010
6B8M
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BU of 6b8m by Molmil
Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak
分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 4, ...
著者Chang, A, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Calmodulin C-Lobe Ca
Neuron, 97, 2018
6B8Q
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BU of 6b8q by Molmil
Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex
分子名称: Calmodulin-1, MAGNESIUM ION, Potassium voltage-gated channel subfamily KQT member 5
著者Chang, A, Abderemane-Ali, F, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Calmodulin C-Lobe Ca
Neuron, 97, 2018
6B8P
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BU of 6b8p by Molmil
Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex
分子名称: Calmodulin-1, MAGNESIUM ION, Potassium voltage-gated channel subfamily KQT member 4, ...
著者Chang, A, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A Calmodulin C-Lobe Ca
Neuron, 97, 2018
3OX5
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BU of 3ox5 by Molmil
Crystal Structure of the calcium sensor calcium-binding protein 1 (CaBP1)
分子名称: CALCIUM ION, Calcium-binding protein 1
著者Findeisen, F, Minor, D.L.
登録日2010-09-21
公開日2010-12-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Basis for the Differential Effects of CaBP1 and Calmodulin on Ca(V)1.2 Calcium-Dependent Inactivation.
Structure, 18, 2010
6CQ9
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BU of 6cq9 by Molmil
K2P2.1(TREK-1):ML402 complex
分子名称: CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ...
著者Lolicato, M, Minor, D.L.
登録日2018-03-14
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017
5V2Q
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BU of 5v2q by Molmil
CaV beta2a subunit: CaV1.2 AID-CEN complex
分子名称: 1,3-bis(bromomethyl)benzene, CHLORIDE ION, Voltage-dependent L-type calcium channel subunit alpha-1C, ...
著者Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L.
登録日2017-03-06
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci, 8, 2017
5V2P
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BU of 5v2p by Molmil
CaV beta2a subunit: CaV1.2 AID-CAP complex
分子名称: 1,3-bis(bromomethyl)benzene, NICKEL (II) ION, PENTAETHYLENE GLYCOL, ...
著者Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L.
登録日2017-03-06
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci, 8, 2017
6B8N
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BU of 6b8n by Molmil
Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak
分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 4, ...
著者Chang, A, Minor, D.L.
登録日2017-10-09
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献A Calmodulin C-Lobe Ca
Neuron, 97, 2018
6CQ8
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BU of 6cq8 by Molmil
K2P2.1(TREK-1):ML335 complex
分子名称: CADMIUM ION, HEXADECANE, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, ...
著者Lolicato, M, Minor, D.L.
登録日2018-03-14
公開日2018-03-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature, 547, 2017

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