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PDB: 42 件
8FX1
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BU of 8fx1 by Molmil
Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to (R)-SerMe-ImmH Phosphonate
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, [(3R)-4-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}butyl]phosphonic acid
著者Hughes, R, Meneely, K.M, Glockzin, K, Clinch, K, Tyler, P.C, Lamb, A.L, Meek, T.D, Katzfuss, A.
登録日2023-01-23
公開日2023-07-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry, 62, 2023
8FX0
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BU of 8fx0 by Molmil
Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to (S)-SerMe-ImmH Phosphonate
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, [(3R)-4-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}butyl]phosphonic acid
著者Hughes, R, Meneely, K.M, Glockzin, K, Clinch, K, Tyler, P.C, Lamb, A.L, Meek, T.D, Katzfuss, A.
登録日2023-01-23
公開日2023-07-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry, 62, 2023
8FX2
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BU of 8fx2 by Molmil
Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-HP
分子名称: (1S)-1(9-DEAZAHYPOXANTHIN-9YL)1,4-DIDEOXY-1,4-IMINO-D-RIBITOL-5-PHOSPHATE, Hypoxanthine-guanine phosphoribosyltransferase
著者Hughes, R, Meneely, K.M, Glockzin, K, Suthagar, K, Tyler, P.C, Lamb, A.L, Meek, T.D, Katzfuss, A.
登録日2023-01-23
公開日2023-07-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry, 62, 2023
8FWZ
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BU of 8fwz by Molmil
Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Hydroxypropyl-Lin-ImmH Phosphonate
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, PHOSPHATE ION, [(2R)-2-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl]phosphonic acid
著者Hughes, R, Meneely, K.M, Glockzin, K, Clinch, K, Tyler, P.C, Lamb, A.L, Meek, T.D, Katzfuss, A.
登録日2023-01-23
公開日2023-07-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry, 62, 2023
7UEH
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BU of 7ueh by Molmil
Pyruvate kinase from Zymomonas mobilis
分子名称: GLYCEROL, PHOSPHATE ION, Pyruvate kinase
著者McFarlane, J.S, Meneely, K.M, Lamb, A.L.
登録日2022-03-21
公開日2023-03-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The 2.4 angstrom structure of Zymomonas mobilis pyruvate kinase: Implications for stability and regulation.
Arch.Biochem.Biophys., 744, 2023
7UEZ
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BU of 7uez by Molmil
Apo RibB from Vibrio cholera
分子名称: 3,4-dihydroxy-2-butanone 4-phosphate synthase
著者Kenjic, N, Meneely, K.M, Lamb, A.L.
登録日2022-03-22
公開日2022-07-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.08 Å)
主引用文献Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis.
J.Am.Chem.Soc., 144, 2022
7UF5
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RibB from Vibrio cholera bound with intermediate 2 in the reaction cycle and the products DHBP and formate
分子名称: (2R)-2-(dihydroxymethyl)-2-hydroxy-3-oxobutyl dihydrogen phosphate, (2R)-2-hydroxy-3-oxobutyl dihydrogen phosphate, 3,4-dihydroxy-2-butanone 4-phosphate synthase, ...
著者Kenjic, N, Meneely, K.M, Lamb, A.L.
登録日2022-03-22
公開日2022-07-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis.
J.Am.Chem.Soc., 144, 2022
7UF0
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BU of 7uf0 by Molmil
RibB from Vibrio cholera bound with D-ribulose-5-phosphate (D-Ru5P)
分子名称: 3,4-dihydroxy-2-butanone 4-phosphate synthase, RIBULOSE-5-PHOSPHATE
著者Kenjic, N, Meneely, K.M, Lamb, A.L.
登録日2022-03-22
公開日2022-07-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis.
J.Am.Chem.Soc., 144, 2022
7UF1
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BU of 7uf1 by Molmil
RibB from Vibrio cholera bound with D-Ribose-5-phosphate (D-R5P) and manganese
分子名称: 3,4-dihydroxy-2-butanone 4-phosphate synthase, MANGANESE (II) ION, RIBOSE-5-PHOSPHATE
著者Kenjic, N, Meneely, K.M, Lamb, A.L.
登録日2022-03-22
公開日2022-07-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis.
J.Am.Chem.Soc., 144, 2022
7UF4
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BU of 7uf4 by Molmil
RibB from Vibrio cholera bound with intermediate 1 of the reaction cycle and D-ribulose-5-phosphate (D-Ru5P)
分子名称: (2R)-2-hydroxy-3,4-dioxopentyl dihydrogen phosphate, 1,2-ETHANEDIOL, 3,4-dihydroxy-2-butanone 4-phosphate synthase, ...
著者Kenjic, N, Meneely, K.M, Lamb, A.L.
登録日2022-03-22
公開日2022-07-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis.
J.Am.Chem.Soc., 144, 2022
7UF2
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BU of 7uf2 by Molmil
RibB from Vibrio cholera bound with D-xylulose-5-phosphate (D-Xy5P) and manganese
分子名称: 1,2-ETHANEDIOL, 3,4-dihydroxy-2-butanone 4-phosphate synthase, 5-O-phosphono-D-xylulose, ...
著者Kenjic, N, Meneely, K.M, Lamb, A.L.
登録日2022-03-22
公開日2022-07-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis.
J.Am.Chem.Soc., 144, 2022
7UF3
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BU of 7uf3 by Molmil
RibB from Vibrio cholera bound with L-xylulose-5-phosphate (L-Xy5P) and manganese
分子名称: 3,4-dihydroxy-2-butanone 4-phosphate synthase, L-xylulose-5-phosphate, MANGANESE (II) ION
著者Kenjic, N, Meneely, K.M, Lamb, A.L.
登録日2022-03-22
公開日2022-07-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis.
J.Am.Chem.Soc., 144, 2022
3E6I
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BU of 3e6i by Molmil
Human cytochrome P450 2E1 in complex with the inhibitor indazole
分子名称: 1H-indazole, Cytochrome P450 2E1, PROTOPORPHYRIN IX CONTAINING FE
著者Porubsky, P.R, Meneely, K.M, Scott, E.E.
登録日2008-08-15
公開日2008-09-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of human cytochrome P450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates.
J.Biol.Chem., 283, 2008
6NN4
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BU of 6nn4 by Molmil
The structure of human liver pyruvate kinase, hLPYK-D499N, in complex with Fru-1,6-BP
分子名称: 1,2-ETHANEDIOL, 1,6-di-O-phosphono-beta-D-fructofuranose, PHOSPHOENOLPYRUVATE, ...
著者McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L.
登録日2019-01-14
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond.
Acta Crystallogr.,Sect.F, 75, 2019
6NN5
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The structure of human liver pyruvate kinase, hLPYK-W527H
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Pyruvate kinase PKLR
著者McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L.
登録日2019-01-14
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.256 Å)
主引用文献Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond.
Acta Crystallogr.,Sect.F, 75, 2019
6NN7
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BU of 6nn7 by Molmil
The structure of human liver pyruvate kinase, hLPYK-GGG
分子名称: 1,2-ETHANEDIOL, CITRATE ANION, GLYCEROL, ...
著者McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L.
登録日2019-01-14
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond.
Acta Crystallogr.,Sect.F, 75, 2019
6NN8
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BU of 6nn8 by Molmil
The structure of human liver pyruvate kinase, hLPYK-S531E
分子名称: 1,2-ETHANEDIOL, Pyruvate kinase PKLR
著者McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L.
登録日2019-01-14
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.416 Å)
主引用文献Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond.
Acta Crystallogr.,Sect.F, 75, 2019
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