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PDB: 70 件
3ZWG
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Crystal structure of the pore-forming toxin FraC from Actinia fragacea (form 2)
分子名称: FRAGACEATOXIN C
著者Mechaly, A.E, Bellomio, A, Morante, K, Gonzalez-Manas, J.M, Guerin, D.M.A.
登録日2011-07-29
公開日2012-07-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Pores of the Toxin Frac Assemble Into 2D Hexagonal Clusters in Both Crystal Structures and Model Membranes.
J.Struct.Biol., 180, 2012
3ZWJ
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BU of 3zwj by Molmil
CRYSTAL STRUCTURE OF THE PORE-FORMING TOXIN FRAC FROM ACTINIA FRAGACEA (Form 3)
分子名称: FRAGACEATOXIN C
著者Mechaly, A.E, Bellomioa, A, Morantea, K, Gonzalez-Manas, J.M, Guerin, D.M.A.
登録日2011-08-01
公開日2012-07-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Pores of the Toxin Frac Assemble Into 2D Hexagonal Clusters in Both Crystal Structures and Model Membranes.
J.Struct.Biol., 180, 2012
3LIM
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BU of 3lim by Molmil
Crystal structure of the pore forming toxin frac from sea anemone actinia fragacea
分子名称: Fragaceatoxin C, LAURYL DIMETHYLAMINE-N-OXIDE
著者Mechaly, A.E, Bellomio, A, Morante, K, Gonzalez-Manas, J.M, Guerin, D.M.A.
登録日2010-01-25
公開日2010-12-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins.
Structure, 19, 2011
6NQX
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BU of 6nqx by Molmil
Flagellar protein FcpA from Leptospira biflexa / primitive monoclinic form
分子名称: Flagellar coiling protein A, GLYCEROL
著者Mechaly, A, Larrieux, N, Trajtenberg, F, Buschiazzo, A.
登録日2019-01-22
公開日2020-01-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献An asymmetric sheath controls flagellar supercoiling and motility in the Leptospira spirochete
Elife, 9, 2020
5LFK
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BU of 5lfk by Molmil
Crystal structure of CpxAHDC (hemiphosphorylated form)
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ...
著者Mechaly, A.E, Alzari, P.M.
登録日2016-07-01
公開日2017-06-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.094 Å)
主引用文献Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase.
Structure, 25, 2017
6NQY
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BU of 6nqy by Molmil
Flagellar protein FcpA from Leptospira biflexa / ab-centered monoclinic form
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Flagellar coiling protein A, ...
著者Mechaly, A, Larrieux, N, Trajtenberg, F, Buschiazzo, A.
登録日2019-01-22
公開日2020-01-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献An asymmetric sheath controls flagellar supercoiling and motility in the Leptospira spirochete.
Elife, 9, 2020
8Q5P
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BU of 8q5p by Molmil
Structure of the lysine methyltransferase SETD2 in complex with a peptide derived from human tyrosine kinase ACK1
分子名称: Activated CDC42 kinase 1, Histone-lysine N-methyltransferase SETD2, S-ADENOSYLMETHIONINE, ...
著者Mechaly, A, Le Coadou, L, Dupret, J.M, Haouz, A, Rodrigues Lima, F.
登録日2023-08-09
公開日2024-04-24
実験手法X-RAY DIFFRACTION (1.814 Å)
主引用文献Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.
Biochem.Biophys.Res.Commun., 695, 2024
7PSZ
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BU of 7psz by Molmil
Crystal structure of CaM in complex with CDZ (form 1)
分子名称: 1-[bis(4-chlorophenyl)methyl]-3-[(2~{R})-2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole, CALCIUM ION, Calmodulin-1, ...
著者Mechaly, A.E, Leger, C, Haouz, A, Chenal, A.
登録日2021-09-24
公開日2022-08-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.898 Å)
主引用文献Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Bmc Biol., 20, 2022
7PU9
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Crystal structure of CaM in complex with CDZ (form 2)
分子名称: 1-[bis(4-chlorophenyl)methyl]-3-[(2~{R})-2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole, CALCIUM ION, Calmodulin-1
著者Mechaly, A.E, Leger, C, Haouz, A, Chenal, A.
登録日2021-09-28
公開日2022-08-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.279 Å)
主引用文献Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Bmc Biol., 20, 2022
6ZZ9
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Crystal structure of CbpB from Streptococcus agalactiae
分子名称: CBS domain-containing protein, PLATINUM (II) ION, SULFATE ION
著者Mechaly, A.E, Covaleda-Cortes, G, Kaminski, P.A.
登録日2020-08-04
公開日2021-08-18
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.644 Å)
主引用文献The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.
Febs J., 2023
4UHS
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BU of 4uhs by Molmil
Crystal structure of the receiver domain of CpxR from E. coli (tetragonal form)
分子名称: MAGNESIUM ION, TRANSCRIPTIONAL REGULATORY PROTEIN CPXR
著者Mechaly, A.E, Alzari, P.M.A.
登録日2015-03-25
公開日2016-04-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (5 Å)
主引用文献Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.
J. Struct. Biol., 204, 2018
4UHK
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BU of 4uhk by Molmil
Crystal structure of the receiver domain of CpxR from E. coli (phosphorylated)
分子名称: MAGNESIUM ION, TRANSCRIPTIONAL REGULATORY PROTEIN CPXR
著者Mechaly, A.E, Alzari, P.M.A.
登録日2015-03-24
公開日2016-04-13
最終更新日2017-06-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase.
Structure, 25, 2017
4UHT
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BU of 4uht by Molmil
Crystal structure of the DNA binding domain of CpxR from E. coli
分子名称: CHLORIDE ION, TRANSCRIPTIONAL REGULATORY PROTEIN CPXR
著者Mechaly, A.E, Alzari, P.M.A.
登録日2015-03-25
公開日2016-04-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.
J. Struct. Biol., 204, 2018
4UHJ
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BU of 4uhj by Molmil
Crystal structure of the receiver domain of CpxR from E. coli (orthorhombic form)
分子名称: MAGNESIUM ION, TRANSCRIPTIONAL REGULATORY PROTEIN CPXR
著者Mechaly, A.E, Alzari, P.M.A.
登録日2015-03-24
公開日2016-04-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase.
Structure, 25, 2017
6ZZA
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BU of 6zza by Molmil
Crystal structure of CbpB in complex with c-di-AMP
分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CBS domain-containing protein, SULFATE ION
著者Mechaly, A.E, Covaleda-Cortes, G, Kaminski, P.A.
登録日2020-08-04
公開日2021-08-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.491 Å)
主引用文献Crystal structure of CbpB in complex with c-di-AMP
To Be Published
8CND
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BU of 8cnd by Molmil
Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
分子名称: ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate, histone acetyltransferase
著者Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
登録日2023-02-22
公開日2024-03-06
実験手法X-RAY DIFFRACTION (2.972 Å)
主引用文献Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
To Be Published
8CN0
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BU of 8cn0 by Molmil
Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with Coenzyme A
分子名称: COENZYME A, ZINC ION, histone acetyltransferase
著者Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
登録日2023-02-21
公開日2024-03-06
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with Coenzyme A
To Be Published
8CNB
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BU of 8cnb by Molmil
Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A
分子名称: COENZYME A, ZINC ION, histone acetyltransferase
著者Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
登録日2023-02-22
公開日2024-03-06
実験手法X-RAY DIFFRACTION (1.986 Å)
主引用文献Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A
To Be Published
8CNA
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BU of 8cna by Molmil
Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
分子名称: ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate, histone acetyltransferase
著者Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
登録日2023-02-22
公開日2024-03-06
実験手法X-RAY DIFFRACTION (2.463 Å)
主引用文献Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
To Be Published
8CMZ
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BU of 8cmz by Molmil
Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A
分子名称: COENZYME A, ZINC ION, histone acetyltransferase
著者Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
登録日2023-02-21
公開日2024-03-06
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A
To Be Published
6ZZ4
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BU of 6zz4 by Molmil
Crystal structure of the PTPN2 C216G mutant
分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 2
著者Mechaly, A.E, Berthelet, J, Nian, Q, Parlato, M, Cerf-Bensussan, N, Haouz, A, Rodrigues-Lima, F.
登録日2020-08-03
公開日2021-08-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.
Protein Sci., 31, 2022
6YNU
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BU of 6ynu by Molmil
CaM-P458 complex (crystal form 1)
分子名称: Bifunctional adenylate cyclase toxin/hemolysin CyaA, CALCIUM ION, Calmodulin-1
著者Mechaly, A.E, Voegele, A, Haouz, A, Chenal, A.
登録日2020-04-14
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Adv Sci, 8, 2021
6YNS
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BU of 6yns by Molmil
CaM-P458 complex (crystal form 2)
分子名称: Bifunctional adenylate cyclase toxin/hemolysin CyaA, CALCIUM ION, Calmodulin-1
著者Mechaly, A.E, Voegele, A, Haouz, A, Chenal, A.
登録日2020-04-14
公開日2021-03-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.94 Å)
主引用文献A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Adv Sci, 8, 2021
4BIZ
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BU of 4biz by Molmil
Crystal structure of CpxAHDC (orthorhombic form 2)
分子名称: ADENOSINE-5'-DIPHOSPHATE, SENSOR PROTEIN CPXA, SULFATE ION
著者Mechaly, A.E, Sassoon, N, Betton, J.M, Alzari, P.M.
登録日2013-04-13
公開日2014-04-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal Structures of Cpxahdc
To be Published
8OG2
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BU of 8og2 by Molmil
Crystal structure of CREBBP histone acetyltransferase domain in complex with Coenzyme A
分子名称: COENZYME A, SODIUM ION, SULFATE ION, ...
著者Mechaly, A.E, Zhang, W, Haouz, A, Green, M, Rodrigues-Lima, F.
登録日2023-03-17
公開日2024-04-03
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Crystal structure of CREBBP histone acetyltransferase domain in complex with Coenzyme A
To Be Published

 

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