PDB Search results for query - Protein Data Bank Japan

PDB: 110 results

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-14
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5L

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-14
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5O

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	McGowan, S.
Deposit date:	2013-04-15
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

2H4R

Crystal structure of wildtype MENT in the native conformation
Descriptor:	Heterochromatin-associated protein MENT
Authors:	Irving, J.A, Whisstock, J.C, Buckle, A.M, McGowan, S.
Deposit date:	2006-05-25
Release date:	2006-07-18
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation. Embo J., 25, 2006

7T3V

Metal dependent activation of Plasmodium falciparum M17 aminopeptidase, spacegroup P22121 after crystals soaked with Zn2+
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, CARBONATE ION, M17 leucyl aminopeptidase, ...
Authors:	Webb, C.T, McGowan, S.
Deposit date:	2021-12-08
Release date:	2022-06-29
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase. J.Biol.Chem., 298, 2022

7SRV

Metal dependent activation of Plasmodium falciparum M17 aminopeptidase (inactive form), spacegroup P22121
Descriptor:	1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:	Webb, C.T, McGowan, S.
Deposit date:	2021-11-08
Release date:	2022-06-29
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.03 Å)
Cite:	A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase. J.Biol.Chem., 298, 2022

6EED

X-ray crystal structure of Pf-M1 in complex with inhibitor (6p) and catalytic zinc ion
Descriptor:	(2R)-2-[(cyclohexylacetyl)amino]-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2018-08-13
Release date:	2018-12-26
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62, 2019

6EA2

X-ray crystal structure of Pf-M1 in complex with inhibitor (6h) and catalytic zinc ion
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2018-08-02
Release date:	2018-12-26
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.35 Å)
Cite:	Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62, 2019

6EE3

X-ray crystal structure of Pf-M1 in complex with inhibitor (6k) and catalytic zinc ion
Descriptor:	(1R,2r,3S,5R,7R)-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]tricyclo[3.3.1.1~3,7~]decane-2-carboxamide, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2018-08-13
Release date:	2018-12-26
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.82 Å)
Cite:	Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62, 2019

6EAB

X-ray crystal structure of Pf-M1 in complex with inhibitor (6j) and catalytic zinc ion
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2018-08-02
Release date:	2018-12-26
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62, 2019

6EAA

X-ray crystal structure of Pf-M1 in complex with inhibitor (6i) and catalytic zinc ion
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2018-08-02
Release date:	2018-12-26
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62, 2019

2DUT

Crystal structure of a M-loop deletion variant of MENT in the native conformation
Descriptor:	Heterochromatin-associated protein MENT
Authors:	Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A.
Deposit date:	2006-07-26
Release date:	2006-08-08
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation Embo J., 25, 2006

4ZX5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX8

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 9b
Descriptor:	CARBONATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZYQ

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10s
Descriptor:	CARBONATE ION, N-{(1R)-2-(hydroxyamino)-1-[3'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide, PENTAETHYLENE GLYCOL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-22
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY0

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10q
Descriptor:	CARBONATE ION, GLYCEROL, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(thiophen-3-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-21
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY2

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10o
Descriptor:	CARBONATE ION, DIMETHYL SULFOXIDE, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluorobiphenyl-4-yl)ethyl]-2,2-dimethylpropanamide, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-21
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX9

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10b
Descriptor:	CARBONATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9f
Descriptor:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b
Descriptor:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX4

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW7

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9m
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW8

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9r
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-19
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s
Descriptor:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2015-05-20
Release date:	2016-03-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

<123 4 5 >

Total results:	110
Displayed results:	25
Sorted by:	Hit score (from highest)
Deposition authors:	"McGowan, S"