3M0B
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![BU of 3m0b by Molmil](/molmil-images/mine/3m0b) | Ru-Porphyrin Protein Scaffolds for Sensing O2 | Descriptor: | CARBON MONOXIDE, Methyl-accepting chemotaxis protein, [3,3'-(7,12-diethyl-3,8,13,17-tetramethylporphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~)dipropanoato(2-)]ruthenium | Authors: | Winter, M.B, McLaurin, E.J, Reece, S.Y, Olea Jr, C, Nocera, D.G, Marletta, M.A. | Deposit date: | 2010-03-02 | Release date: | 2010-04-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Ru-porphyrin protein scaffolds for sensing O2. J.Am.Chem.Soc., 132, 2010
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4U9G
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![BU of 4u9g by Molmil](/molmil-images/mine/4u9g) | Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II)CO ligation state, Q154A/Q155A/K156A mutant | Descriptor: | CARBON MONOXIDE, NO-binding heme-dependent sensor protein, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Herzik Jr, M.A, Jonnalagadda, R, Kuriyan, J, Marletta, M.A. | Deposit date: | 2014-08-06 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc.Natl.Acad.Sci.USA, 111, 2014
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4U9K
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![BU of 4u9k by Molmil](/molmil-images/mine/4u9k) | Crystal structure of an H-NOX protein from S. oneidensis in the Mn(II)NO ligation state, Q154A/Q155A/K156A mutant | Descriptor: | MANGANESE PROTOPORPHYRIN IX, NITRIC OXIDE, NO-binding heme-dependent sensor protein, ... | Authors: | Herzik Jr, M.A, Jonnalagadda, R, Kuriyan, J, Marletta, M.A. | Deposit date: | 2014-08-06 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc.Natl.Acad.Sci.USA, 111, 2014
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4U99
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![BU of 4u99 by Molmil](/molmil-images/mine/4u99) | Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II) ligation state, Q154A/Q155A/K156A mutant | Descriptor: | NO-binding heme-dependent sensor protein, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ... | Authors: | Herzik Jr, M.A, Jonnalagadda, R, Kuriyan, J, Marletta, M.A. | Deposit date: | 2014-08-05 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc.Natl.Acad.Sci.USA, 111, 2014
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4U9J
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![BU of 4u9j by Molmil](/molmil-images/mine/4u9j) | Crystal structure of an H-NOX protein from S. oneidensis in the Mn(II) ligation state, Q154A/Q155A/K156A mutant | Descriptor: | MANGANESE PROTOPORPHYRIN IX, NO-binding heme-dependent sensor protein, SODIUM ION, ... | Authors: | Herzik Jr, M.A, Jonnalagadda, R, Kuriyan, J, Marletta, M.A. | Deposit date: | 2014-08-06 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc.Natl.Acad.Sci.USA, 111, 2014
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4U9B
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![BU of 4u9b by Molmil](/molmil-images/mine/4u9b) | Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II)NO ligation state | Descriptor: | GLYCEROL, NITRIC OXIDE, NO-binding heme-dependent sensor protein, ... | Authors: | Herzik Jr, M.A, Jonnalagadda, R, Kuriyan, J, Marletta, M.A. | Deposit date: | 2014-08-05 | Release date: | 2014-10-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc.Natl.Acad.Sci.USA, 111, 2014
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3LAI
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![BU of 3lai by Molmil](/molmil-images/mine/3lai) | Structural insights into the molecular mechanism of H-NOX activation | Descriptor: | IMIDAZOLE, Methyl-accepting chemotaxis protein, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Olea Jr, C, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2010-01-06 | Release date: | 2010-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.144 Å) | Cite: | Structural insights into the molecular mechanism of H-NOX activation. Protein Sci., 19, 2010
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3LAH
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![BU of 3lah by Molmil](/molmil-images/mine/3lah) | Structural insights into the molecular mechanism of H-NOX activation | Descriptor: | IMIDAZOLE, Methyl-accepting chemotaxis protein, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Olea Jr, C, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2010-01-06 | Release date: | 2010-03-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into the molecular mechanism of H-NOX activation. Protein Sci., 19, 2010
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4IT2
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![BU of 4it2 by Molmil](/molmil-images/mine/4it2) | Mn(III)-PPIX bound Tt H-NOX | Descriptor: | MANGANESE PROTOPORPHYRIN IX, Methyl-accepting chemotaxis protein | Authors: | Winter, M.B, Klemm, P.J, Phillips-Piro, C.M, Raymond, K.M, Marletta, M.A. | Deposit date: | 2013-01-17 | Release date: | 2013-02-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.097 Å) | Cite: | Porphyrin-Substituted H-NOX Proteins as High-Relaxivity MRI Contrast Agents. Inorg.Chem., 52, 2013
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3MVC
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![BU of 3mvc by Molmil](/molmil-images/mine/3mvc) | High resolution crystal structure of the heme domain of GLB-6 from C. elegans | Descriptor: | Globin protein 6, NITRATE ION, PRASEODYMIUM ION, ... | Authors: | Yoon, J, Herzik Jr, M.A, Winter, M.B, Tran, R, Olea Jr, C, Marletta, M.A. | Deposit date: | 2010-05-03 | Release date: | 2010-06-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans. Biochemistry, 49, 2010
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5UFV
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![BU of 5ufv by Molmil](/molmil-images/mine/5ufv) | |
6BDE
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![BU of 6bde by Molmil](/molmil-images/mine/6bde) | Crystal structure of Fe(II) unliganded H-NOX protein mutant A71G from K. algicida | Descriptor: | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Bruegger, J.J, Hespen, C.W, Marletta, M.A. | Deposit date: | 2017-10-22 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.641 Å) | Cite: | Native Alanine Substitution in the Glycine Hinge Modulates Conformational Flexibility of Heme Nitric Oxide/Oxygen (H-NOX) Sensing Proteins. ACS Chem. Biol., 13, 2018
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6BDD
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![BU of 6bdd by Molmil](/molmil-images/mine/6bdd) | Crystal structure of Fe(II) unliganded H-NOX protein from K. algicida | Descriptor: | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Bruegger, J.J, Hespen, C.W, Marletta, M.A. | Deposit date: | 2017-10-22 | Release date: | 2018-05-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Native Alanine Substitution in the Glycine Hinge Modulates Conformational Flexibility of Heme Nitric Oxide/Oxygen (H-NOX) Sensing Proteins. ACS Chem. Biol., 13, 2018
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3IQB
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![BU of 3iqb by Molmil](/molmil-images/mine/3iqb) | Tt I75F/L144F H-NOX | Descriptor: | Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Weinert, E.E, Plate, L, Whited, C.A, Olea Jr, C, Marletta, M.A. | Deposit date: | 2009-08-19 | Release date: | 2010-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Determinants of Ligand Affinity and Heme Reactivity in H-NOX Domains. Angew.Chem.Int.Ed.Engl., 49, 2009
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6PAS
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![BU of 6pas by Molmil](/molmil-images/mine/6pas) | Inactive State of Manduca sexta soluble guanylate cyclase | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Soluble guanylyl cyclase alpha-1 subunit, Soluble guanylyl cyclase beta-1 subunit | Authors: | Yokom, A.L, Horst, B.G, Marletta, M.A, Hurley, J.H. | Deposit date: | 2019-06-11 | Release date: | 2019-10-23 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. Elife, 8, 2019
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6PAT
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![BU of 6pat by Molmil](/molmil-images/mine/6pat) | Active State of Manduca sexta soluble Guanylate Cyclase | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Soluble guanylyl cyclase alpha-1 subunit, Soluble guanylyl cyclase beta-1 subunit | Authors: | Yokom, A.L, Horst, B.G, Marletta, M.A, Hurley, J.H. | Deposit date: | 2019-06-11 | Release date: | 2019-10-23 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. Elife, 8, 2019
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3EEE
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![BU of 3eee by Molmil](/molmil-images/mine/3eee) | Probing the function of heme distortion in the H-NOX family | Descriptor: | CHLORIDE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | Authors: | Olea Jr, C, Boon, E.M, Pellicena, P, Kuriyan, J, Marletta, M.A. | Deposit date: | 2008-09-04 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Probing the function of heme distortion in the H-NOX family. Acs Chem.Biol., 3, 2008
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3TF1
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![BU of 3tf1 by Molmil](/molmil-images/mine/3tf1) | Crystal structure of an H-NOX protein from T. tengcongensis under 6 atm of xenon | Descriptor: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.0369 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFF
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![BU of 3tff by Molmil](/molmil-images/mine/3tff) | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L67W mutant | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9401 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF0
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![BU of 3tf0 by Molmil](/molmil-images/mine/3tf0) | Crystal structure of an H-NOX protein from T. tengcongensis | Descriptor: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.743 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFE
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![BU of 3tfe by Molmil](/molmil-images/mine/3tfe) | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant under 6 atm of xenon | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.991 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3ET6
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![BU of 3et6 by Molmil](/molmil-images/mine/3et6) | The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase | Descriptor: | PHOSPHATE ION, Soluble guanylyl cyclase beta | Authors: | Winger, J.A, Derbyshire, E.R, Lamers, M.H, Marletta, M.A, Kuriyan, J. | Deposit date: | 2008-10-07 | Release date: | 2008-10-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. Bmc Struct.Biol., 8, 2008
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3TFG
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![BU of 3tfg by Molmil](/molmil-images/mine/3tfg) | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W/L67W double mutant | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9003 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFD
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![BU of 3tfd by Molmil](/molmil-images/mine/3tfd) | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFA
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![BU of 3tfa by Molmil](/molmil-images/mine/3tfa) | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 6 atm of xenon | Descriptor: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, XENON | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2711 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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