4LMQ
| Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 | Descriptor: | Stromal cell-derived factor 1, hu30D8 Fab heavy chain, hu30D8 Fab light chain | Authors: | Zhong, Z, Wang, J, Li, B, Xiang, H, Ultsch, M, Coons, M, Wong, T, Chiang, N.Y, Clark, S, Clark, R, Quintana, L, Gribling, P, Suto, E, Barck, K, Corpuz, R, Yao, J, Takkar, R, Lee, W.P, Damico-Beyer, L.A, Carano, R.D, Adams, C, Kelley, R.F, Wang, W, Ferrara, N. | Deposit date: | 2013-07-10 | Release date: | 2013-08-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.773 Å) | Cite: | Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12. Clin.Cancer Res., 19, 2013
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2W7S
| SplA serine protease of Staphylococcus aureus (1.8A) | Descriptor: | SERINE PROTEASE SPLA | Authors: | Stec-Niemczyka, J, Pustelny, K, Kisielewska, M, Bista, M, Boulware, K.T, Stennicke, H.R, Thogersen, I.B, Daugherty, P.S, Enghild, J.J, Popowicz, G.M, Dubin, A, Potempa, J, Dubin, G. | Deposit date: | 2008-12-30 | Release date: | 2010-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and Functional Characterization of Spla, an Exclusively Specific Protease of Staphylococcus Aureus Biochem.J., 419, 2009
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1KK9
| CRYSTAL STRUCTURE OF E. COLI YCIO | Descriptor: | SULFATE ION, probable translation factor yciO | Authors: | Jia, J, Lunin, V.V, Sauve, V, Huang, L.-W, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2001-12-06 | Release date: | 2002-12-11 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the YciO protein from Escherichia coli PROTEINS: STRUCT.,FUNCT.,GENET., 49, 2002
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1KKS
| Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression | Descriptor: | 5'-R(*GP*GP*AP*AP*GP*GP*CP*CP*CP*UP*UP*UP*UP*CP*AP*GP*GP*GP*CP*CP*AP*CP*CP*C)-3' | Authors: | Zanier, K, Luyten, I, Crombie, C, Muller, B, Schuemperli, D, Linge, J.P, Nilges, M, Sattler, M. | Deposit date: | 2001-12-10 | Release date: | 2002-03-13 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression. RNA, 8, 2002
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2WFM
| Crystal structure of polyneuridine aldehyde esterase mutant (H244A) | Descriptor: | POLYNEURIDINE ALDEHYDE ESTERASE | Authors: | Yang, L, Hill, M, Panjikar, S, Wang, M, Stoeckigt, J. | Deposit date: | 2009-04-08 | Release date: | 2010-04-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis and Enzymatic Mechanism of the Biosynthesis of C9- from C10-Monoterpenoid Indole Alkaloids. Angew.Chem.Int.Ed.Engl., 48, 2009
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1KMA
| NMR Structure of the Domain-I of the Kazal-type Thrombin Inhibitor Dipetalin | Descriptor: | DIPETALIN | Authors: | Schlott, B, Wohnert, J, Icke, C, Hartmann, M, Ramachandran, R, Guhrs, K.-H, Glusa, E, Flemming, J, Gorlach, M, Grosse, F, Ohlenschlager, O. | Deposit date: | 2001-12-14 | Release date: | 2002-05-15 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Interaction of Kazal-type inhibitor domains with serine proteinases: biochemical and structural studies. J.Mol.Biol., 318, 2002
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1KN9
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1KS0
| The First Fibronectin Type II Module from Human Matrix Metalloproteinase 2 | Descriptor: | Matrix Metalloproteinase 2 | Authors: | Gehrmann, M, Briknarova, K, Banyai, L, Patthy, L, Llinas, M. | Deposit date: | 2002-01-10 | Release date: | 2002-02-20 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains. Biol.Chem., 383, 2002
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4PI8
| Crystal structure of catalytic mutant E138A of S. Aureus Autolysin E in complex with disaccharide NAG-NAM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-beta-muramic acid, Autolysin E, CHLORIDE ION, ... | Authors: | Mihelic, M, Renko, M, Jakas, A, Turk, D. | Deposit date: | 2014-05-08 | Release date: | 2015-10-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers Iucrj, 4, 2017
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4KMI
| Crystal structure of 4-O-beta-D-mannosyl-D-glucose phosphorylase MGP complexed with PO4 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-O-beta-D-mannosyl-D-glucose phosphorylase, PHOSPHATE ION | Authors: | Nakae, S, Ito, S, Higa, M, Senoura, T, Wasaki, J, Hijikata, A, Shionyu, M, Ito, S, Shirai, T. | Deposit date: | 2013-05-08 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of Novel Enzyme in Mannan Biodegradation Process 4-O-beta-d-Mannosyl-d-Glucose Phosphorylase MGP J.Mol.Biol., 425, 2013
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4KJM
| Crystal structure of the Staphylococcus aureus protein (NP_646141.1, domain 3912-4037) similar to streptococcal adhesins emb and ebhA/ebhB | Descriptor: | ACETATE ION, CHLORIDE ION, Extracellular matrix-binding protein ebh, ... | Authors: | Cymborowski, M, Shabalin, I.G, Joachimiak, G, Chruszcz, M, Gornicki, P, Zhang, R, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2013-05-03 | Release date: | 2013-05-29 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the Staphylococcus aureus protein (NP_646141.1, domain 3912-4037) similar to streptococcal adhesins emb and ebhA/ebhB To be Published
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1JKT
| TETRAGONAL CRYSTAL FORM OF A CATALYTIC DOMAIN OF DEATH-ASSOCIATED PROTEIN KINASE | Descriptor: | DEATH-ASSOCIATED PROTEIN KINASE | Authors: | Tereshko, V, Teplova, M, Brunzelle, J, Watterson, D.M, Egli, M. | Deposit date: | 2001-07-13 | Release date: | 2002-04-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat.Struct.Biol., 8, 2001
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2WAM
| Crystal structure of Mycobacterium tuberculosis unknown function protein Rv2714 | Descriptor: | CONSERVED HYPOTHETICAL ALANINE AND LEUCINE RICH PROTEIN, GLYCEROL | Authors: | Bellinzoni, M, Grana, M, Buschiazzo, A, Miras, I, Haouz, A, Alzari, P.M. | Deposit date: | 2009-02-09 | Release date: | 2009-10-06 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of Mycobacterium Tuberculosis Rv2714, a Representative of a Duplicated Gene Family in Actinobacteria. Acta Crystallogr.,Sect.F, 65, 2009
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3A3V
| Crystal structure of reducing-end-xylose releasing exo-oligoxylanase Y198F mutant | Descriptor: | GLYCEROL, NICKEL (II) ION, Xylanase Y | Authors: | Hidaka, M, Fushinobu, S, Honda, Y, Kitaoka, M. | Deposit date: | 2009-06-22 | Release date: | 2009-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Structural explanation for the acquisition of glycosynthase activity J.Biochem., 147, 2010
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4JYL
| Crystal structure of enoyl-CoA hydratase from Thermoplasma volcanium GSS1 | Descriptor: | CHLORIDE ION, Enoyl-CoA hydratase, SULFATE ION | Authors: | Shabalin, I.G, Cooper, D.R, Majorek, K.A, Mikolajczak, K, Porebski, P.J, Stead, M, Hillerich, B.S, Ahmed, M, Bonanno, J, Seidel, R, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-03-29 | Release date: | 2013-04-17 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Crystal structure of enoyl-CoA hydratase from Thermoplasma volcanium GSS1 To be Published
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2R2O
| Crystal structure of the effector domain of human Plexin B1 | Descriptor: | Plexin-B1, UNKNOWN ATOM OR ION | Authors: | Tong, Y, Tempel, W, Shen, L, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-08-27 | Release date: | 2007-09-04 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J.Biol.Chem., 282, 2007
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4KFO
| Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors | Descriptor: | 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Zheng, X, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Han, B, Ho, Y, Kley, N, Lin, J, Reynolds, D.J, Sharma, G, Smith, C.C, Wang, Z, Dragovich, P.S, Gunzner-Tosteb, J, Liederer, B.M, Ly, J, O'Brien, T, Oh, A, Wang, L, Wang, W, Xiao, Y, Zak, M, Zhao, G, Yuen, P, Bair, K.W. | Deposit date: | 2013-04-27 | Release date: | 2013-05-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. J.Med.Chem., 56, 2013
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1K1Z
| Solution structure of N-terminal SH3 domain mutant(P33G) of murine Vav | Descriptor: | vav | Authors: | Ogura, K, Nagata, K, Horiuchi, M, Ebisui, E, Hasuda, T, Yuzawa, S, Nishida, M, Hatanaka, H, Inagaki, F. | Deposit date: | 2001-09-26 | Release date: | 2001-10-10 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain J.BIOMOL.NMR, 22, 2002
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1JKC
| HUMAN LYSOZYME MUTANT WITH TRP 109 REPLACED BY PHE | Descriptor: | LYSOZYME, NITRATE ION | Authors: | Muraki, M, Harata, K, Goda, S, Nagahora, H. | Deposit date: | 1996-11-13 | Release date: | 1997-05-15 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Importance of van der Waals contact between Glu 35 and Trp 109 to the catalytic action of human lysozyme. Protein Sci., 6, 1997
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2QSR
| Crystal structure of C-terminal domain of transcription-repair coupling factor | Descriptor: | Transcription-repair coupling factor | Authors: | Ramagopal, U.A, Toro, R, Gilmore, M, Bain, K, Iizuka, M, Wasserman, S, Rodgers, L, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2007-07-31 | Release date: | 2007-09-11 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of C-terminal domain of transcription-repair coupling factor. To be Published
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2VPY
| Polysulfide reductase with bound quinone inhibitor, pentachlorophenol (PCP) | Descriptor: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, HYPOTHETICAL MEMBRANE SPANNING PROTEIN, IRON/SULFUR CLUSTER, ... | Authors: | Jormakka, M, Yokoyama, K, Yano, T, Tamakoshi, M, Akimoto, S, Shimamura, T, Curmi, P, Iwata, S. | Deposit date: | 2008-03-09 | Release date: | 2008-06-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular Mechanism of Energy Conservation in Polysulfide Respiration. Nat.Struct.Mol.Biol., 15, 2008
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2VPW
| Polysulfide reductase with bound menaquinone | Descriptor: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, HYPOTHETICAL MEMBRANE SPANNING PROTEIN, IRON/SULFUR CLUSTER, ... | Authors: | Jormakka, M, Yokoyama, K, Yano, T, Tamakoshi, M, Akimoto, S, Shimamura, T, Curmi, P, Iwata, S. | Deposit date: | 2008-03-09 | Release date: | 2008-06-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Molecular Mechanism of Energy Conservation in Polysulfide Respiration. Nat.Struct.Mol.Biol., 15, 2008
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3WEX
| Crystal structure of HLA-DP5 in complex with Cry j 1-derived peptide (residues 214-222) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II antigen | Authors: | Kusano, S, Kukimoto-Niino, M, Shirouzu, M, Yokoyama, S. | Deposit date: | 2013-07-16 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the specific recognition of the major antigenic peptide from the Japanese cedar pollen allergen Cry j 1 by HLA-DP5 J. Mol. Biol., 426, 2014
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3WGE
| Crystal structure of ERp46 Trx2 | Descriptor: | GLYCEROL, Thioredoxin domain-containing protein 5 | Authors: | Inaba, K, Suzuki, M, Kojima, R. | Deposit date: | 2013-08-04 | Release date: | 2014-06-25 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Radically different thioredoxin domain arrangement of ERp46, an efficient disulfide bond introducer of the mammalian PDI family Structure, 22, 2014
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2WD1
| Human c-Met Kinase in complex with azaindole inhibitor | Descriptor: | 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE, GAMMA-BUTYROLACTONE, HEPATOCYTE GROWTH FACTOR RECEPTOR | Authors: | Porter, J, Lumb, S, Franklin, R.J, Gascon-Simorte, J.M, Calmiano, M, Le Riche, K, Lallemand, B, Keyaerts, J, Edwards, H, Maloney, A, Delgado, J, King, L, Foley, A, Lecomte, F, Reuberson, J, Meier, C, Batchelor, M. | Deposit date: | 2009-03-19 | Release date: | 2009-04-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of 4-Azaindoles as Novel Inhibitors of C- met Kinase. Bioorg.Med.Chem.Lett., 19, 2009
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