5Y90
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![BU of 5y90 by Molmil](/molmil-images/mine/5y90) | MAP2K7 mutant -C218S | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL | Authors: | Kinoshita, T, Hashimoto, T, Sogabe, Y, Matsumoto, T, Sawa, M, Fukada, H. | Deposit date: | 2017-08-22 | Release date: | 2017-10-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7 Biochem. Biophys. Res. Commun., 493, 2017
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6QIE
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![BU of 6qie by Molmil](/molmil-images/mine/6qie) | Crystal structure of DEAH-box ATPase Prp43-S387G | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Hamann, F, Ficner, R, Enders, M. | Deposit date: | 2019-01-18 | Release date: | 2019-03-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for RNA translocation by DEAH-box ATPases. Nucleic Acids Res., 47, 2019
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6QAW
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![BU of 6qaw by Molmil](/molmil-images/mine/6qaw) | ERK2 mini-fragment binding | Descriptor: | Mitogen-activated protein kinase 1, SULFATE ION, [1-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methylazanium | Authors: | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | Deposit date: | 2018-12-19 | Release date: | 2019-03-27 | Last modified: | 2019-05-22 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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5YBL
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![BU of 5ybl by Molmil](/molmil-images/mine/5ybl) | Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AusE | Descriptor: | 2-OXOGLUTARIC ACID, MANGANESE (II) ION, Multifunctional dioxygenase ausE | Authors: | Nakashima, Y, Senda, M. | Deposit date: | 2017-09-05 | Release date: | 2018-01-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.108 Å) | Cite: | Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis. Nat Commun, 9, 2018
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5YCO
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![BU of 5yco by Molmil](/molmil-images/mine/5yco) | Complex structure of PCNA with UHRF2 | Descriptor: | E3 ubiquitin-protein ligase UHRF2, GLYCEROL, Proliferating cell nuclear antigen, ... | Authors: | Wu, M, Chen, W, Hang, T, Wang, C, Zhang, X, Zang, J. | Deposit date: | 2017-09-07 | Release date: | 2017-11-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA. Biochem. Biophys. Res. Commun., 494, 2017
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6QHN
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![BU of 6qhn by Molmil](/molmil-images/mine/6qhn) | Metagenome-derived salicylaldehyde dehydrogenase from alpine soil in complex with protocatechuic acid | Descriptor: | 3,4-DIHYDROXYBENZOIC ACID, GLYCEROL, SALICYLALDEHYDE DEHYDROGENASE | Authors: | Hakansson, M, Svensson, L.A, Shamsudeen, D.U, Allen, C.C.R. | Deposit date: | 2019-01-17 | Release date: | 2020-02-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil. Acta Crystallogr.,Sect.F, 78, 2022
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6QAQ
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![BU of 6qaq by Molmil](/molmil-images/mine/6qaq) | ERK2 mini-fragment binding | Descriptor: | Mitogen-activated protein kinase 1, SULFATE ION, thiophen-3-ylmethylazanium | Authors: | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | Deposit date: | 2018-12-19 | Release date: | 2019-03-27 | Last modified: | 2019-05-22 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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6QBD
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![BU of 6qbd by Molmil](/molmil-images/mine/6qbd) | Crystal structure of NLPPya P41A, D44N, N48E mutant | Descriptor: | 25 kDa protein elicitor, MAGNESIUM ION | Authors: | Lenarcic, T, Podobnik, M, Anderluh, G. | Deposit date: | 2018-12-21 | Release date: | 2019-08-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Molecular basis for functional diversity among microbial Nep1-like proteins. Plos Pathog., 15, 2019
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6QBV
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![BU of 6qbv by Molmil](/molmil-images/mine/6qbv) | |
5YM9
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![BU of 5ym9 by Molmil](/molmil-images/mine/5ym9) | |
6QD0
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![BU of 6qd0 by Molmil](/molmil-images/mine/6qd0) | MloK1 model from single particle analysis of 2D crystals, class 4 (compact/open conformation) | Descriptor: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | Authors: | Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H. | Deposit date: | 2018-12-31 | Release date: | 2019-04-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM. Nat Commun, 10, 2019
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5YR9
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![BU of 5yr9 by Molmil](/molmil-images/mine/5yr9) | Crystal Structure of Cypovirus Polyhedra R13A/E73C/Y83C Mutant | Descriptor: | 1,2-ETHANEDIOL, Polyhedrin | Authors: | Negishi, H, Abe, S, Yamashita, K, Hirata, K, Niwase, K, Boudes, M, Coulibaly, F, Mori, H, Ueno, T. | Deposit date: | 2017-11-08 | Release date: | 2018-02-21 | Last modified: | 2018-03-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Supramolecular protein cages constructed from a crystalline protein matrix Chem. Commun. (Camb.), 54, 2018
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5YOQ
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![BU of 5yoq by Molmil](/molmil-images/mine/5yoq) | |
5YRM
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![BU of 5yrm by Molmil](/molmil-images/mine/5yrm) | PPL3C-isomaltose complex | Descriptor: | PPL3-b, SULFATE ION, alpha-D-glucopyranose-(1-6)-beta-D-glucopyranose | Authors: | Nakae, S, Shionyu, M, Ogawa, T, Shirai, T. | Deposit date: | 2017-11-09 | Release date: | 2018-08-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structures of jacalin-related lectin PPL3 regulating pearl shell biomineralization Proteins, 86, 2018
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7UWH
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![BU of 7uwh by Molmil](/molmil-images/mine/7uwh) | CryoEM Structure of E. coli Transcription-Coupled Ribonucleotide Excision Repair (TC-RER) complex bound to ribonucleotide substrate | Descriptor: | DNA (59-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Hao, Z.T, Grower, M, Bharati, B, Proshkin, S, Epshtein, V, Svetlov, V, Nudler, E, Shamovsky, I. | Deposit date: | 2022-05-03 | Release date: | 2023-05-31 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | RNA polymerase drives ribonucleotide excision DNA repair in E. coli. Cell, 186, 2023
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7UWE
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![BU of 7uwe by Molmil](/molmil-images/mine/7uwe) | CryoEM Structure of E. coli Transcription-Coupled Ribonucleotide Excision Repair (TC-RER) complex | Descriptor: | DNA (29-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Hao, Z.T, Grower, M, Bharati, B, Proshkin, S, Epshtein, V, Svetlov, V, Nudler, E, Shamovsky, I. | Deposit date: | 2022-05-03 | Release date: | 2023-05-31 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | RNA polymerase drives ribonucleotide excision DNA repair in E. coli. Cell, 186, 2023
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8SR6
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6QDY
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![BU of 6qdy by Molmil](/molmil-images/mine/6qdy) | The crystal structure of Sporosarcina pasteurii urease in complex with its substrate urea | Descriptor: | 1,2-ETHANEDIOL, FLUORIDE ION, NICKEL (II) ION, ... | Authors: | Mazzei, L, Cianci, M, Benini, S, Ciurli, S. | Deposit date: | 2019-01-03 | Release date: | 2019-11-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.416 Å) | Cite: | The Structure of the Elusive Urease-Urea Complex Unveils the Mechanism of a Paradigmatic Nickel-Dependent Enzyme. Angew.Chem.Int.Ed.Engl., 58, 2019
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5YSQ
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![BU of 5ysq by Molmil](/molmil-images/mine/5ysq) | Sulfate-complex structure of a pyrophosphate-dependent kinase in the ribokinase family provides insight into the donor-binding mode | Descriptor: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, SULFATE ION, TM0415 | Authors: | Nagata, R, Fujihashi, M, Miki, K. | Deposit date: | 2017-11-14 | Release date: | 2018-05-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants. Nat Commun, 9, 2018
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6QEO
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![BU of 6qeo by Molmil](/molmil-images/mine/6qeo) | Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the 3-Oxo-beta-Sultam inhibitor LMC269 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-methyl-1-[[1-[(4-nitrophenyl)methyl]-1,2,3-triazol-4-yl]methylamino]-1-oxidanylidene-propane-2-sulfonic acid, Chymotrypsin-like elastase family member 1, ... | Authors: | Brito, J.A, Almeida, V.T, Carvalho, L.M, Moreira, R, Archer, M. | Deposit date: | 2019-01-08 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | 3-Oxo-beta-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling. Acs Chem.Biol., 15, 2020
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6QG9
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![BU of 6qg9 by Molmil](/molmil-images/mine/6qg9) | Crystal structure of Ideonella sakaiensis MHETase | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Palm, G.J, Reisky, L, Boettcher, D, Mueller, H, Michels, E.A.P, Walczak, C, Berndt, L, Weiss, M.S, Bornscheuer, U.T, Weber, G. | Deposit date: | 2019-01-10 | Release date: | 2019-04-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to a substrate. Nat Commun, 10, 2019
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5YTQ
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![BU of 5ytq by Molmil](/molmil-images/mine/5ytq) | Crystal Structure of TTHA0139 L34A with Lanthanum from Thermus thermophilus HB8 | Descriptor: | LANTHANUM (III) ION, TTHA0139 | Authors: | Takao, K, Inoue, M, Fukui, K, Yano, T, Masui, R. | Deposit date: | 2017-11-19 | Release date: | 2018-11-21 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.393 Å) | Cite: | Crystal Structure of TTHA0139 L34A with Lanthanum from Thermus thermophilus HB8 To Be Published
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5YSY
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![BU of 5ysy by Molmil](/molmil-images/mine/5ysy) | Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2R,3R)-5-[(E)-2-{(1R,3aS,7aR)-1-[(R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}vinyl]-2-(3-hydroxypropyl)cyclohex-4-ene-1,3-diol | Descriptor: | (1R,2R,3R)-5-[(E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]e thenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol, Vitamin D3 receptor | Authors: | Takimoto-Kamimura, M, Kakuda, S. | Deposit date: | 2017-11-16 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor. Org. Biomol. Chem., 16, 2018
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6QIC
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5YT2
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![BU of 5yt2 by Molmil](/molmil-images/mine/5yt2) | Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2S,3R)-5-[(E)-2-{(1R,3aS,7aR)-1-[(R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}vinyl]-2-(3-hydroxypropyl)cyclohex-4-ene-1,3-diol | Descriptor: | (1R,2S,3R)-5-[(E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol, Vitamin D3 receptor | Authors: | Takimoto-Kamimura, M, Kakuda, S. | Deposit date: | 2017-11-16 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor. Org. Biomol. Chem., 16, 2018
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