4D2R
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![BU of 4d2r by Molmil](/molmil-images/mine/4d2r) | Human IGF in complex with a Dyrk1B inhibitor | Descriptor: | CHLORIDE ION, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine | Authors: | Debreczeni, J.E, Kettle, J.G, Ballard, P, Bardelle, C, Butterworth, S, Colclough, N, Critchlow, S.E, Fairley, G, Fillery, S, Graham, M.A, Goodwin, L, Guichard, S, Hudson, K, Mahmood, A, Vincent, J, Ward, R.A, Whittaker, D. | Deposit date: | 2014-05-12 | Release date: | 2015-04-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis. J.Med.Chem., 58, 2015
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4C6I
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![BU of 4c6i by Molmil](/molmil-images/mine/4c6i) | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 7.0 | Descriptor: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD PROTEIN, FORMIC ACID, ... | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4C6K
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![BU of 4c6k by Molmil](/molmil-images/mine/4c6k) | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 8.0 | Descriptor: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD PROTEIN, FORMIC ACID, ... | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-02-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.478 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4C6J
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![BU of 4c6j by Molmil](/molmil-images/mine/4c6j) | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 7.5 | Descriptor: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD PROTEIN, FORMIC ACID, ... | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-02-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.299 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4BY3
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![BU of 4by3 by Molmil](/molmil-images/mine/4by3) | Crystal structure of the dihydroorotase domain of human CAD in apo- form obtained recombinantly from E. coli. | Descriptor: | DIHYDROOROTASE, FORMIC ACID, ZINC ION | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-07-17 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structure, Functional Characterization, and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4C6L
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![BU of 4c6l by Molmil](/molmil-images/mine/4c6l) | Crystal structure of the dihydroorotase domain of human CAD bound to the inhibitor fluoroorotate at pH 6.0 | Descriptor: | 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD PROTEIN, FORMIC ACID, ... | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-02-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4C6B
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![BU of 4c6b by Molmil](/molmil-images/mine/4c6b) | Crystal structure of the dihydroorotase domain of human CAD with incomplete active site, obtained recombinantly from E. coli. | Descriptor: | CAD PROTEIN, FORMIC ACID, GLYCEROL | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-02-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.656 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4C6P
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![BU of 4c6p by Molmil](/molmil-images/mine/4c6p) | Crystal structure of the dihydroorotase domain of human CAD C1613S mutant in apo-form at pH 7.0 | Descriptor: | CAD PROTEIN, FORMIC ACID, ZINC ION | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-02-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.518 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4C6C
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![BU of 4c6c by Molmil](/molmil-images/mine/4c6c) | Crystal structure of the dihydroorotase domain of human CAD in apo- form obtained recombinantly from HEK293 cells. | Descriptor: | CAD PROTEIN, FORMIC ACID, ZINC ION | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.451 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4C6O
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![BU of 4c6o by Molmil](/molmil-images/mine/4c6o) | Crystal structure of the dihydroorotase domain of human CAD C1613S mutant in apo-form at pH 6.0 | Descriptor: | CAD PROTEIN, FORMIC ACID, ZINC ION | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-02-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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4C6M
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![BU of 4c6m by Molmil](/molmil-images/mine/4c6m) | Crystal structure of the dihydroorotase domain of human CAD bound to the inhibitor fluoroorotate at pH 7.0 | Descriptor: | 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD PROTEIN, FORMIC ACID, ... | Authors: | Ramon-Maiques, S, Lallous, N, Grande-Garcia, A. | Deposit date: | 2013-09-18 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22, 2014
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2C5D
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![BU of 2c5d by Molmil](/molmil-images/mine/2c5d) | Structure of a minimal Gas6-Axl complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GROWTH-ARREST-SPECIFIC PROTEIN 6 PRECURSOR, ... | Authors: | Sasaki, T, Knyazev, P.G, Clout, N.J, Cheburkin, Y, Goehring, W, Ullrich, A, Timpl, R, Hohenester, E. | Deposit date: | 2005-10-26 | Release date: | 2005-12-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural Basis for Gas6-Axl Signalling. Embo J., 25, 2006
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1QHV
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![BU of 1qhv by Molmil](/molmil-images/mine/1qhv) | HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD | Descriptor: | PROTEIN (ADENOVIRUS FIBRE), SULFATE ION | Authors: | Van Raaij, M.J, Louis, N, Chroboczek, J, Cusack, S. | Deposit date: | 1999-05-28 | Release date: | 1999-09-29 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution. Virology, 262, 1999
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2A0Q
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![BU of 2a0q by Molmil](/molmil-images/mine/2a0q) | Structure of thrombin in 400 mM potassium chloride | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, POTASSIUM ION, ... | Authors: | Papaconstantinou, M, Carrell, C.J, Pineda, A.O, Bobofchak, K.M, Mathews, F.S, Flordellis, C.S, Maragoudakis, M.E, Tsopanoglou, N.E, di Cera, E. | Deposit date: | 2005-06-16 | Release date: | 2005-07-12 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Thrombin Functions through Its RGD Sequence in a Non-canonical Conformation. J.Biol.Chem., 280, 2005
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2QEJ
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![BU of 2qej by Molmil](/molmil-images/mine/2qej) | Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Ramsland, P.A, Willoughby, N, Trist, H.M, Farrugia, W, Hogarth, P.M, Fraser, J.D, Wines, B.D. | Deposit date: | 2007-06-26 | Release date: | 2007-09-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1 Proc.Natl.Acad.Sci.Usa, 104, 2007
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