6A4H
 
 | | Mandelate oxidase mutant-Y128F with the peroxide FMN adduct | | Descriptor: | 4-hydroxymandelate oxidase, [(2~{R},3~{S},4~{S})-5-[(4~{a}~{S})-4~{a}-(dioxidanyl)-7,8-dimethyl-2,4-bis(oxidanylidene)-5~{H}-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] dihydrogen phosphate | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-19 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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5ZZQ
 | | The crystal structure of Mandelate oxidase with (S)-4-Hydroxymandelic acid | | Descriptor: | (2S)-hydroxy(4-hydroxyphenyl)ethanoic acid, 4-hydroxymandelate oxidase, FLAVIN MONONUCLEOTIDE | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-04 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction.
Acta Crystallogr D Struct Biol, 75, 2019
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6A11
 | | Mandelate oxidase mutant-Y128F with phenylpyruvic acid | | Descriptor: | 3-PHENYLPYRUVIC ACID, 4-hydroxymandelate oxidase, FLAVIN MONONUCLEOTIDE | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-06 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction.
Acta Crystallogr D Struct Biol, 75, 2019
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6A1B
 | | Mandelate oxidase mutant-Y128F with 3,3,3-trifluoro-2,2-dihydroxypropanoic acid | | Descriptor: | 3,3,3-trifluoro-2,2-dihydroxypropanoic acid, 4-hydroxymandelate oxidase, FLAVIN MONONUCLEOTIDE | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-07 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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6A1M
 | | Mandelate oxidase mutant-Y128F with 5-deazariboflavin mononucleotide and benzoylformic acid | | Descriptor: | 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase, BENZOYL-FORMIC ACID, ... | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-07 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level.
Acta Crystallogr D Struct Biol, 75, 2019
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6A4G
 | | Mandelate oxidase mutant-Y128F with the monooxide FMN adduct | | Descriptor: | 1-deoxy-1-[(4aS)-4a-hydroxy-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-19 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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5ZZX
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6A00
 | | The crystal structure of Mandelate oxidase with (S)-2-phenylpropionate | | Descriptor: | (2~{S})-2-phenylpropanoic acid, 4-hydroxymandelate oxidase, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-05 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction.
Acta Crystallogr D Struct Biol, 75, 2019
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6A36
 | | Mandelate oxidase mutant-Y128F with the 3-fluoropyruvic acid FMN adduct | | Descriptor: | 1-deoxy-1-{5-[(1S)-2-fluoro-1-hydroxyethyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-5-O-phosphono-D-ribitol, 1-{5-[(3S)-3-carboxy-4-fluoro-3-hydroxybutanoyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-1-deoxy-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-15 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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6A0B
 | | The crystal structure of Mandelate oxidase mutant Y128F with (R)-3,3,3-trifluoro-2-hydroxy-propionic acid | | Descriptor: | (2R)-3,3,3-trifluoro-2-hydroxypropanoic acid, 4-hydroxymandelate oxidase, FLAVIN MONONUCLEOTIDE | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-05 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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6A1P
 | | Mandelate oxidase mutant-Y128F with 5-deazariboflavin mononucleotide and phenylpyruvic acid | | Descriptor: | 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-5-O-phosphono-D-ribitol, 3-PHENYLPYRUVIC ACID, 4-hydroxymandelate oxidase, ... | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-07 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level.
Acta Crystallogr D Struct Biol, 75, 2019
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6A24
 | | The crystal structure of Mandelate oxidase with 3-fluoropyruvate | | Descriptor: | 4-hydroxymandelate oxidase, FLAVIN MONONUCLEOTIDE, FLUORIDE ION, ... | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-08 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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6A0M
 | | Mandelate oxidase mutant-Y128F with 2-Phenylacetic acid | | Descriptor: | 2-PHENYLACETIC ACID, 4-hydroxymandelate oxidase, FLAVIN MONONUCLEOTIDE | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-05 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction.
Acta Crystallogr D Struct Biol, 75, 2019
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6A0D
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6A0O
 | | Mandelate oxidase mutant-Y128F with benzaldehyde | | Descriptor: | 4-hydroxymandelate oxidase, FLAVIN MONONUCLEOTIDE, benzaldehyde | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-06 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction.
Acta Crystallogr D Struct Biol, 75, 2019
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6A0Y
 | | Mandelate oxidase mutant-Y128F with Benzoic acid | | Descriptor: | 4-hydroxymandelate oxidase, BENZOIC ACID, FLAVIN MONONUCLEOTIDE | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-06 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Biochemical and structural explorations of alpha-hydroxyacid oxidases reveal a four-electron oxidative decarboxylation reaction.
Acta Crystallogr D Struct Biol, 75, 2019
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6A1R
 | | Mandelate oxidase mutant-Y128F with the N5-phenylacetyl-FMN adduct | | Descriptor: | 1-deoxy-1-[7,8-dimethyl-2,4-dioxo-5-(phenylacetyl)-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase, MAGNESIUM ION | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-08 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.652 Å) | | Cite: | The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level.
Acta Crystallogr D Struct Biol, 75, 2019
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6A1H
 | | Mandelate oxidase mutant-Y128F with 5-deazariboflavin mononucleotide | | Descriptor: | 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-07 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level.
Acta Crystallogr D Struct Biol, 75, 2019
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6AI7
 | | Mandelate oxidase mutant-Y128F with the C4a-OH-FMN adduct | | Descriptor: | 1-deoxy-1-[(4aS)-4a-hydroxy-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-08-21 | | Release date: | 2019-08-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | The crystal structure of Mandelate oxidase mutant-Y128F with the C4a-OH-FMN adduct
To Be Published
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6A1L
 | | Mandelate oxidase mutant-Y128F with 5-deazariboflavin mononucleotide and benzoic acid | | Descriptor: | 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl)-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase, BENZOIC ACID, ... | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-07 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level.
Acta Crystallogr D Struct Biol, 75, 2019
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6A3D
 | | The crystal structure of Mandelate oxidase Y128F with 4-Br-2-hydroxy-methylphenylacetate | | Descriptor: | 1-deoxy-1-[(4aS)-4a-[(methoxycarbonyl)peroxy]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-15 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.923 Å) | | Cite: | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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6A3T
 | | The crystal structure of Mandelate oxidase R163L with 2-hydroxy-phenylacetamide | | Descriptor: | 1-{5-[(1S)-2-amino-1-hydroxy-2-oxo-1-phenylethyl]-7,8-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrobenzo[g]pteridine-5,10-diium-10-yl}-1-deoxy-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | Authors: | Li, T.L, Lin, K.H. | | Deposit date: | 2018-06-16 | | Release date: | 2019-06-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.511 Å) | | Cite: | The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level.
Acta Crystallogr D Struct Biol, 75, 2019
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