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PDB: 497 件
5F6L
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The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L
分子名称: Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Li, Y, Lei, M, Chen, Y.
登録日2015-12-06
公開日2016-02-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F5E
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The Crystal Structure of MLL1 SET domain with N3816I/Q3867L mutation
分子名称: Histone-lysine N-methyltransferase 2A, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION
著者Li, Y, Lei, M, Chen, Y.
登録日2015-12-04
公開日2016-02-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
3OIP
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BU of 3oip by Molmil
Crystal structure of Yeast telomere protein Cdc13 OB1
分子名称: Cell division control protein 13
著者Sun, J, Yang, Y, Wan, K, Mao, N, Yu, T.Y, Lin, Y.C, DeZwaan, D.C, Freeman, B.C, Lin, J.J, Lue, N.F, Lei, M.
登録日2010-08-19
公開日2010-11-03
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.504 Å)
主引用文献Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase alpha.
Cell Res., 21, 2011
3RSN
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Crystal Structure of the N-terminal region of Human Ash2L
分子名称: Set1/Ash2 histone methyltransferase complex subunit ASH2, ZINC ION
著者Chen, Y, Wan, B, Wang, K.C, Cao, F, Yang, Y, Protacio, A, Dou, Y, Chang, H.Y, Lei, M.
登録日2011-05-02
公開日2011-06-22
最終更新日2011-12-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.
Embo Rep., 12, 2011
3RMH
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Crystal Structure of yeast telomere protein Cdc13 OB4
分子名称: Yeast Cdc13 OB4
著者Sun, J, Yang, Y, Lei, M.
登録日2011-04-20
公開日2011-11-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Analyses of Candida Cdc13 Orthologues Revealed a Novel OB Fold Dimer Arrangement, Dimerization-Assisted DNA Binding, and Substantial Structural Differences between Cdc13 and RPA70.
Mol.Cell.Biol., 32, 2012
3TOJ
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Structure of the SPRY domain of human Ash2L
分子名称: Set1/Ash2 histone methyltransferase complex subunit ASH2
著者Chen, Y, Cao, F, Wan, B, Dou, Y, Lei, M.
登録日2011-09-05
公開日2012-01-25
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
Cell Res., 22, 2012
3U88
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Crystal structure of human menin in complex with MLL1 and LEDGF
分子名称: (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ...
著者Huang, J, Wan, B, Lei, M.
登録日2011-10-16
公開日2012-02-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3OIQ
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Crystal structure of yeast telomere protein Cdc13 OB1 and the catalytic subunit of DNA polymerase alpha Pol1
分子名称: Cell division control protein 13, DNA polymerase alpha catalytic subunit A
著者Sun, J, Yang, Y, Wan, K, Mao, N, Yu, T.Y, Lin, Y.C, DeZwaan, D.C, Freeman, B.C, Lin, J.J, Lue, N.F, Lei, M.
登録日2010-08-19
公開日2010-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase alpha.
Cell Res., 21, 2011
3OWT
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Crystal structure of S. cerevisiae RAP1-Sir3 complex
分子名称: DNA-binding protein RAP1, Regulatory protein SIR3
著者Chen, Y, Yang, Y, Lei, M.
登録日2010-09-20
公開日2011-01-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
3U58
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Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 AB
分子名称: DNA (5'-D(*GP*GP*GP*T)-3'), Tetrahymena Teb1 AB
著者Zeng, Z, Huang, J, Yang, Y, Lei, M.
登録日2011-10-11
公開日2011-12-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.613 Å)
主引用文献Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U50
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Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C
分子名称: Telomerase-associated protein 82, ZINC ION
著者Zeng, Z, Huang, J, Yang, Y, Lei, M.
登録日2011-10-10
公開日2011-12-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U84
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Crystal Structure of Human Menin
分子名称: Menin
著者Huang, J, Wan, B, Lei, M.
登録日2011-10-15
公開日2012-02-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
8HPP
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Crystal structure of human INTS3 with SAGE1
分子名称: Integrator complex subunit 3, Sarcoma antigen 1
著者Deng, W, Wu, J, Lei, M.
登録日2022-12-12
公開日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Cancer-testis antigen SAGE1 is a pan-cancer master regulator of RNA polymerase II
To Be Published
3U85
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Crystal structure of human menin in complex with MLL1
分子名称: Histone-lysine N-methyltransferase 2A, Menin
著者Huang, J, Wan, B, Lei, M.
登録日2011-10-15
公開日2012-02-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3U86
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Crystal structure of human menin in complex with JunD
分子名称: Menin, Transcription factor jun-D
著者Huang, J, Wan, B, Lei, M.
登録日2011-10-15
公開日2012-02-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.843 Å)
主引用文献The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3U4V
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Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-A
分子名称: Telomerase-associated protein 82
著者Zeng, Z, Huang, J, Yang, Y, Lei, M.
登録日2011-10-10
公開日2011-12-28
最終更新日2012-05-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U4Z
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BU of 3u4z by Molmil
Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-B
分子名称: Telomerase-associated protein 82
著者Zeng, Z, Huang, J, Yang, Y, Lei, M.
登録日2011-10-10
公開日2011-12-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA.
Proc.Natl.Acad.Sci.USA, 108, 2011
8HMD
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base module state 2 of Tetrahymena IFT-A
分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ...
著者Ma, Y, Wu, J, Lei, M.
登録日2022-12-03
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.
Nat Commun, 14, 2023
8HME
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head module state 1 of Tetrahymena IFT-A
分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transporter, WD40 repeat protein, ...
著者Ma, Y, Wu, J, Lei, M.
登録日2022-12-03
公開日2023-06-14
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.
Nat Commun, 14, 2023
8HMC
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base module state 1 of Tetrahymena IFT-A
分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ...
著者Ma, Y, Wu, J, Lei, M.
登録日2022-12-03
公開日2023-06-14
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.
Nat Commun, 14, 2023
8HMF
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head module state 2 of Tetrahymena IFT-A
分子名称: Intraflagellar transport protein 122 homolog, Intraflagellar transporter, WD40 repeat protein, ...
著者Ma, Y, Wu, J, Lei, M.
登録日2022-12-03
公開日2023-06-14
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.
Nat Commun, 14, 2023
7X5C
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Solution structure of Tetrahymena p75OB1-p50PBM
分子名称: Telomerase associated protein p50PBM, Telomerase-associated protein p75OB1
著者Wu, B, Tang, T, Xue, H.J, Wu, J, Lei, M.
登録日2022-03-04
公開日2022-10-19
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Association of the CST complex and p50 in Tetrahymena is crucial for telomere maintenance
Structure, 2022
5Y58
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Crystal structure of Ku70/80 and TLC1
分子名称: ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, TLC1
著者Chen, H, Xue, J, Wu, J, Lei, M.
登録日2017-08-08
公開日2017-12-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018
5XXF
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Crystal structure of Poz1, Tpz1 and Rap1
分子名称: Protection of telomeres protein poz1, Protection of telomeres protein tpz1, Rap1, ...
著者Xue, J, Chen, H, Wu, J, Lei, M.
登録日2017-07-03
公開日2017-12-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017
5XXE
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Crystal structure of Poz1 and Tpz1
分子名称: Protection of telomeres protein poz1, Protection of telomeres protein tpz1, SULFATE ION, ...
著者Xue, J, Chen, H, Wu, J, Lei, M.
登録日2017-07-03
公開日2017-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017

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