9EQJ
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![BU of 9eqj by Molmil](/molmil-images/mine/9eqj) | Crystal structure of pVHL:EloB:EloC in complex with MP-1-39 | 分子名称: | (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[cis-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Kroupova, A, Pierri, M, Liu, X, Ciulli, A. | 登録日 | 2024-03-21 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity. Bioorg.Med.Chem.Lett., 110, 2024
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9EQM
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![BU of 9eqm by Molmil](/molmil-images/mine/9eqm) | Crystal structure of pVHL:EloB:EloC in complex with MP-1-21 | 分子名称: | (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[trans-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Kroupova, A, Pierri, M, Liu, X, Ciulli, A. | 登録日 | 2024-03-21 | 公開日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity. Bioorg.Med.Chem.Lett., 110, 2024
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7P3A
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![BU of 7p3a by Molmil](/molmil-images/mine/7p3a) | N-terminal domain of CGI-99 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ISOPROPYL ALCOHOL, ... | 著者 | Kroupova, A, Jinek, M. | 登録日 | 2021-07-07 | 公開日 | 2021-12-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular architecture of the human tRNA ligase complex. Elife, 10, 2021
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7P3B
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![BU of 7p3b by Molmil](/molmil-images/mine/7p3b) | Human RNA ligase RTCB in complex with GMP and Co(II) | 分子名称: | ACETATE ION, COBALT (II) ION, FORMIC ACID, ... | 著者 | Kroupova, A, Ackle, F, Jinek, M. | 登録日 | 2021-07-07 | 公開日 | 2021-12-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular architecture of the human tRNA ligase complex. Elife, 10, 2021
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6RVZ
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![BU of 6rvz by Molmil](/molmil-images/mine/6rvz) | Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate | 分子名称: | ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Kroupova, A, Jinek, M. | 登録日 | 2019-06-03 | 公開日 | 2020-05-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Science, 369, 2020
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6RW0
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![BU of 6rw0 by Molmil](/molmil-images/mine/6rw0) | Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase | 分子名称: | GLYCEROL, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Kroupova, A, Jinek, M. | 登録日 | 2019-06-03 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Science, 369, 2020
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6I0U
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![BU of 6i0u by Molmil](/molmil-images/mine/6i0u) | |
6I0V
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6I0S
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![BU of 6i0s by Molmil](/molmil-images/mine/6i0s) | Crystal structure of DmTailor in complex with UMPNPP | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, Terminal uridylyltransferase Tailor | 著者 | Kroupova, A, Ivascu, A, Jinek, M. | 登録日 | 2018-10-26 | 公開日 | 2018-12-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor. Nucleic Acids Res., 47, 2019
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6I0T
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![BU of 6i0t by Molmil](/molmil-images/mine/6i0t) | |