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PDB: 3 件

6FR2
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BU of 6fr2 by Molmil
Soluble epoxide hydrolase in complex with LK864
分子名称: 1-[(4~{S})-9-propan-2-ylsulfonyl-1-oxa-9-azaspiro[5.5]undecan-4-yl]-3-[[4-(trifluoromethyloxy)phenyl]methyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION
著者Kramer, J.S, Pogoryelov, D, Krasavin, M, Proschak, E.
登録日2018-02-15
公開日2018-09-12
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.262 Å)
主引用文献Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase.
Bioorg. Chem., 80, 2018
5NEA
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BU of 5nea by Molmil
Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-(2-methyl-1,3-oxazol-5-yl)benzene-1-sulfonammide
分子名称: 1,2-ETHANEDIOL, 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide, Carbonic anhydrase 2, ...
著者Ferraroni, M, Supuran, C.T, Krasavin, M.
登録日2017-03-10
公開日2017-12-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.
Bioorg. Med. Chem., 25, 2017
5NEE
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BU of 5nee by Molmil
Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide
分子名称: 5-(2-morpholin-4-ylcarbonyl-1,3-oxazol-5-yl)thiophene-2-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
著者Ferraroni, M, Supuran, C.T, Krasavin, M.
登録日2017-03-10
公開日2017-12-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.
Bioorg. Med. Chem., 25, 2017

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件を2024-07-31に公開中

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