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PDB: 188 results

4D46
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BU of 4d46 by Molmil
Crystal structure of E. coli FabI in complex with NAD and 5-bromo-2-(4-chloro-2-hydroxyphenoxy)benzonitrile
Descriptor: 5-bromo-2-(4-chloro-2-hydroxyphenoxy)benzonitrile, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Tareilus, M, Schiebel, J, Chang, A, Tonge, P.J, Sotriffer, C.A, Kisker, C.
Deposit date:2014-10-26
Release date:2015-03-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction.
Biochemistry, 54, 2015
4D42
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BU of 4d42 by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 4-fluoro- 5-hexyl-2-phenoxyphenol
Descriptor: 4-fluoro-5-hexyl-2-phenoxyphenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ...
Authors:Schiebel, J, Chang, A, Tonge, P.J, Sotriffer, C.A, Kisker, C.
Deposit date:2014-10-26
Release date:2015-03-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.
Biochemistry, 54, 2015
4CUZ
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BU of 4cuz by Molmil
Crystal structure of S. aureus FabI in complex with NADPH and PT173
Descriptor: 1-(3-amino-2-methylbenzyl)-4-hexylpyridin-2(1H)-one, ENOYL-ACP REDUCTASE MOLECULE ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Schiebel, J, Chang, A, Shah, S, Tonge, P.J, Kisker, C.
Deposit date:2014-03-22
Release date:2014-04-16
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor.
J.Biol.Chem., 289, 2014
4D43
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BU of 4d43 by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 2-(2- chloro-4-nitrophenoxy)-5-ethyl-4-fluorophenol
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-(2-chloro-4-nitrophenoxy)-5-ethyl-4-fluorophenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], ...
Authors:Schiebel, J, Chang, A, Tonge, P.J, Sotriffer, C.A, Kisker, C.
Deposit date:2014-10-26
Release date:2015-03-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction.
Biochemistry, 54, 2015
4D44
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BU of 4d44 by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 5-ethyl- 4-fluoro-2-((2-fluoropyridin-3-yl)oxy)phenol
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 5-ethyl-4-fluoro-2-[(2-fluoropyridin-3-yl)oxy]phenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], ...
Authors:Schiebel, J, Chang, A, Tonge, P.J, Sotriffer, C.A, Kisker, C.
Deposit date:2014-10-26
Release date:2015-03-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction.
Biochemistry, 54, 2015
4BNI
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BU of 4bni by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 2-(2- aminophenoxy)-5-hexylphenol
Descriptor: 2-(2-azanylphenoxy)-5-hexyl-phenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ...
Authors:Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C.
Deposit date:2013-05-15
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Biochemistry, 52, 2013
4BNJ
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BU of 4bnj by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 5-methyl- 2-phenoxyphenol
Descriptor: 5-methyl-2-phenoxyphenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ...
Authors:Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C.
Deposit date:2013-05-15
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Biochemistry, 52, 2013
4BNN
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BU of 4bnn by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 2-(2- cyanophenoxy)-5-hexylphenol
Descriptor: 2-(2-CYANOPHENOXY)-5-HEXYLPHENOL, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ...
Authors:Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C.
Deposit date:2013-05-15
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Biochemistry, 52, 2013
4BNK
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BU of 4bnk by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 5-fluoro- 2-phenoxyphenol
Descriptor: 5-fluoro-2-phenoxyphenol, CHLORIDE ION, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], ...
Authors:Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C.
Deposit date:2013-05-15
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Biochemistry, 52, 2013
4BNG
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BU of 4bng by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 5-pentyl- 2-phenoxyphenol
Descriptor: 5-PENTYL-2-PHENOXYPHENOL, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ...
Authors:Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C.
Deposit date:2013-05-15
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Biochemistry, 52, 2013
4BNH
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BU of 4bnh by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 5-hexyl- 2-phenoxyphenol
Descriptor: 5-hexyl-2-phenoxyphenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ...
Authors:Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C.
Deposit date:2013-05-15
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Biochemistry, 52, 2013
4BNM
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BU of 4bnm by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 5-hexyl- 2-(2-methylphenoxy)phenol
Descriptor: 5-HEXYL-2-(2-METHYLPHENOXY)PHENOL, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ...
Authors:Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C.
Deposit date:2013-05-15
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Biochemistry, 52, 2013
4BNF
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BU of 4bnf by Molmil
Crystal structure of S. aureus FabI in complex with NADP and 2- phenoxy-5-propylphenol
Descriptor: 2-phenoxy-5-propyl-phenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ...
Authors:Schiebel, J, Chang, A, Bommineni, G.R, Tonge, P.J, Kisker, C.
Deposit date:2013-05-15
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.
Biochemistry, 52, 2013

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