3P2S
| Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in an open conformation | Descriptor: | Fluoroacetyl coenzyme A thioesterase | Authors: | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | Deposit date: | 2010-10-04 | Release date: | 2010-10-20 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry, 49, 2010
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3P2R
| Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate | Descriptor: | Fluoroacetyl coenzyme A thioesterase, fluoroacetic acid | Authors: | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | Deposit date: | 2010-10-03 | Release date: | 2010-10-20 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry, 49, 2010
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8Q42
| Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-A DNA | Descriptor: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*AP*AP*AP*A)-3'), DUF1887 family protein, ... | Authors: | Jungfer, K, Sigg, A, Jinek, M. | Deposit date: | 2023-08-04 | Release date: | 2023-11-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
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8Q44
| Crystal structure of cA4-bound Can2 (E364R) in complex with oligo-T DNA | Descriptor: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*TP*T)-3'), DUF1887 family protein, ... | Authors: | Jungfer, K, Sigg, A, Jinek, M. | Deposit date: | 2023-08-04 | Release date: | 2023-11-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
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8Q3Y
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8Q3Z
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8QLO
| CryoEM structure of the apo SPARTA (BabAgo/TIR-APAZ) complex | Descriptor: | Short prokaryotic Argonaute, Toll/interleukin-1 receptor domain-containing protein | Authors: | Finocchio, G, Koopal, B, Potocnik, A, Heijstek, C, Jinek, M, Swarts, D. | Deposit date: | 2023-09-20 | Release date: | 2024-01-31 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA. Nucleic Acids Res., 52, 2024
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8BD5
| Cas12k-sgRNA-dsDNA-S15-TniQ-TnsC transposon recruitment complex | Descriptor: | 30S ribosomal protein S15, ADENOSINE-5'-TRIPHOSPHATE, DNA non-target strand, ... | Authors: | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | Deposit date: | 2022-10-18 | Release date: | 2022-12-28 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex. Cell, 185, 2022
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8BD4
| TniQ-capped Tns-ATP-dsDNA complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*C)-3'), MAGNESIUM ION, ... | Authors: | Querques, I, Schmitz, M, Oberli, S, Chanez, C, Jinek, M. | Deposit date: | 2022-10-18 | Release date: | 2022-12-28 | Last modified: | 2023-01-04 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex. Cell, 185, 2022
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8BD6
| Cas12k-sgRNA-dsDNA-TnsC non-productive complex. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cas12k, DNA, ... | Authors: | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | Deposit date: | 2022-10-18 | Release date: | 2022-12-28 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex. Cell, 185, 2022
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6FUW
| Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ... | Authors: | Clerici, M, Faini, M, Jinek, M. | Deposit date: | 2018-02-28 | Release date: | 2018-03-21 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex. Nat. Struct. Mol. Biol., 25, 2018
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7PLH
| Scytonema hofmannii TnsC bound to AMPPNP and DNA | Descriptor: | DNA (5'-D(P*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3'), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Querques, I, Jinek, M. | Deposit date: | 2021-08-31 | Release date: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Target site selection and remodelling by type V CRISPR-transposon systems. Nature, 599, 2021
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7PLA
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6F9N
| CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | Authors: | Clerici, M, Jinek, M. | Deposit date: | 2017-12-14 | Release date: | 2018-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex. Elife, 6, 2017
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7OXD
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5FW1
| Crystal structure of SpyCas9 variant VQR bound to sgRNA and TGAG PAM target DNA | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Bargsten, K, Jinek, M. | Deposit date: | 2016-02-11 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol.Cell, 61, 2016
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6I0S
| Crystal structure of DmTailor in complex with UMPNPP | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, Terminal uridylyltransferase Tailor | Authors: | Kroupova, A, Ivascu, A, Jinek, M. | Deposit date: | 2018-10-26 | Release date: | 2018-12-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor. Nucleic Acids Res., 47, 2019
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6I0V
| Crystal structure of DmTailor in complex with CACAGU RNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*CP*AP*CP*AP*GP*U)-3'), Terminal uridylyltransferase Tailor | Authors: | Kroupova, A, Ivascu, A, Jinek, M. | Deposit date: | 2018-10-26 | Release date: | 2018-12-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.851 Å) | Cite: | Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor. Nucleic Acids Res., 47, 2019
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6I0T
| Crystal structure of DmTailor in complex with GpU | Descriptor: | RNA (5'-R(*GP*U)-3'), Terminal uridylyltransferase Tailor | Authors: | Kroupova, A, Ivascu, A, Jinek, M. | Deposit date: | 2018-10-26 | Release date: | 2018-12-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor. Nucleic Acids Res., 47, 2019
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6I0U
| Crystal structure of DmTailor in complex with U6 RNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*UP*UP*UP*U)-3'), Terminal uridylyltransferase Tailor | Authors: | Kroupova, A, Ivascu, A, Jinek, M. | Deposit date: | 2018-10-26 | Release date: | 2018-12-05 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor. Nucleic Acids Res., 47, 2019
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5FW2
| Crystal structure of SpCas9 variant EQR bound to sgRNA and TGAG PAM target DNA | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Bargsten, K, Jinek, M. | Deposit date: | 2016-02-11 | Release date: | 2016-06-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.676 Å) | Cite: | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol.Cell, 61, 2016
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5FW3
| Crystal structure of SpCas9 variant VRER bound to sgRNA and TGCG PAM target DNA | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Bargsten, K, Jinek, M. | Deposit date: | 2016-02-11 | Release date: | 2016-06-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol.Cell, 61, 2016
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2Y9H
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5FSH
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4BK0
| Crystal structure of the KIX domain of human RECQL5 (domain-swapped dimer) | Descriptor: | ATP-DEPENDENT DNA HELICASE Q5, DI(HYDROXYETHYL)ETHER | Authors: | Kassube, S.A, Jinek, M, Fang, J, Tsutakawa, S, Nogales, E. | Deposit date: | 2013-04-21 | Release date: | 2013-06-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Mimicry in Transcription Regulation of Human RNA Polymerase II by the DNA Helicase Recql5 Nat.Struct.Mol.Biol., 20, 2013
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