7QR0
 
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7QR1
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7QQU
 | | SpCas9 bound to FANCF off-target2 DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target2 non-target strand, FANCF off-target2 target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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7QQZ
 | | SpCas9 bound to FANCF off-target7 DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target7 non-target strand, FANCF off-target7 target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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7PLA
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7QQS
 | | SpCas9 bound to FANCF on-target DNA substrate | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF on-target non-target strand, FANCF on-target target strand, ... | | 著者 | Pacesa, M, Jinek, M. | | 登録日 | 2022-01-10 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for Cas9 off-target activity.
Cell, 185, 2022
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3P2Q
 | | Crystal structure of the fluoroacetyl-CoA-specific thioesterase, FlK | | 分子名称: | Fluoroacetyl coenzyme A thioesterase | | 著者 | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | | 登録日 | 2010-10-03 | | 公開日 | 2010-10-20 | | 最終更新日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
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3P3F
 | | Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK | | 分子名称: | Fluoroacetyl coenzyme A thioesterase | | 著者 | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | | 登録日 | 2010-10-04 | | 公開日 | 2010-10-20 | | 最終更新日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
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3P3I
 | | Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA | | 分子名称: | COENZYME A, Fluoroacetyl coenzyme A thioesterase, fluoroacetic acid | | 著者 | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | | 登録日 | 2010-10-04 | | 公開日 | 2010-10-20 | | 最終更新日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
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3P2S
 | | Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in an open conformation | | 分子名称: | Fluoroacetyl coenzyme A thioesterase | | 著者 | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | | 登録日 | 2010-10-04 | | 公開日 | 2010-10-20 | | 最終更新日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
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3P2R
 | | Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate | | 分子名称: | Fluoroacetyl coenzyme A thioesterase, fluoroacetic acid | | 著者 | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | | 登録日 | 2010-10-03 | | 公開日 | 2010-10-20 | | 最終更新日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
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6F9W
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7OXD
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8Q42
 | | Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-A DNA | | 分子名称: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*AP*AP*AP*A)-3'), DUF1887 family protein, ... | | 著者 | Jungfer, K, Sigg, A, Jinek, M. | | 登録日 | 2023-08-04 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
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8Q44
 | | Crystal structure of cA4-bound Can2 (E364R) in complex with oligo-T DNA | | 分子名称: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*TP*T)-3'), DUF1887 family protein, ... | | 著者 | Jungfer, K, Sigg, A, Jinek, M. | | 登録日 | 2023-08-04 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
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8Q3Y
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8Q3Z
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6I0T
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6I0U
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6I0S
 | | Crystal structure of DmTailor in complex with UMPNPP | | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, Terminal uridylyltransferase Tailor | | 著者 | Kroupova, A, Ivascu, A, Jinek, M. | | 登録日 | 2018-10-26 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor.
Nucleic Acids Res., 47, 2019
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6I0V
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3ICQ
 | | Karyopherin nuclear state | | 分子名称: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | | 登録日 | 2009-07-18 | | 公開日 | 2009-08-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
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3IBV
 | | Karyopherin cytosolic state | | 分子名称: | CALCIUM ION, Exportin-T | | 著者 | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | | 登録日 | 2009-07-17 | | 公開日 | 2009-08-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
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2Y9H
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2Y8Y
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