8I4T
 
 | | Structure of the asymmetric unit of SFTSV virion | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelopment polyprotein | | Authors: | Du, S, Peng, R, Qi, J, Li, C. | | Deposit date: | 2023-01-21 | | Release date: | 2023-09-13 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5.2 Å) | | Cite: | Cryo-EM structure of severe fever with thrombocytopenia syndrome virus.
Nat Commun, 14, 2023
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7TAG
 | | Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain virion in complex with pleconaril | | Descriptor: | 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, viral protein 1, viral protein 2, ... | | Authors: | Fu, J, Klose, T, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2021-12-20 | | Release date: | 2023-01-25 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68
To Be Published
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2VIZ
 | | Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(2-oxo- 1-pyrrolidinyl)-5-(propyloxy)benzamide | | Descriptor: | BETA-SECRETASE 1, N-[(1S,2R)-1-benzyl-3-{[(1S)-2-(cyclohexylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxypropyl]-3-(2-oxo-2,3-dihydro-1H-pyrrol-1-yl)-5-propoxybenzamide | | Authors: | Clarke, B, Demont, E, Dingwall, C, Dunsdon, R, Faller, A, Hawkins, J, Hussain, I, MacPherson, D, Maile, G, Matico, R, Milner, P, Mosley, J, Naylor, A, O'Brien, A, Redshaw, S, Riddell, D, Rowland, P, Soleil, V, Smith, K, Stanway, S, Stemp, G, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Ward, J, Wayne, G. | | Deposit date: | 2007-12-06 | | Release date: | 2008-01-29 | | Last modified: | 2019-05-15 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Bace-1 Inhibitors Part 1: Identification of Novel Hydroxy Ethylamines (Heas).
Bioorg.Med.Chem.Lett., 18, 2008
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7SS6
 | | Structure of Klebsiella LpxH in complex with JH-LPH-45 | | Descriptor: | 1,2-ETHANEDIOL, 5-{4-[3-chloro-5-(trifluoromethyl)phenyl]piperazine-1-sulfonyl}-N-[5-(hydroxyamino)-5-oxopentyl]-2,3-dihydro-1H-indole-1-carboxamide, MANGANESE (II) ION, ... | | Authors: | Cho, J, Cochrane, C.S, Zhou, P. | | Deposit date: | 2021-11-09 | | Release date: | 2023-04-12 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH.
Chemmedchem, 18, 2023
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7SS7
 | | Crystal structure of Klebsiella LpxH in complex with JH-LPH-50 | | Descriptor: | 1,2-ETHANEDIOL, 6-{[(4-{4-[3-chloro-5-(trifluoromethyl)phenyl]piperazine-1-sulfonyl}phenyl)carbamoyl]amino}-N-hydroxyhexanamide, MANGANESE (II) ION, ... | | Authors: | Cho, J, Cochrane, C.S, Zhou, P. | | Deposit date: | 2021-11-09 | | Release date: | 2023-04-12 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH.
Chemmedchem, 18, 2023
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7NWN
 | | A carbohydrate binding module family 9 (CBM9) from Caldicellulsiruptor kristjanssonii | | Descriptor: | 1,2-ETHANEDIOL, Beta-xylanase, CALCIUM ION, ... | | Authors: | Krska, D, Mazurkewich, S, Navarro Poulsen, J, Larsbrink, J, Lo Leggio, L. | | Deposit date: | 2021-03-17 | | Release date: | 2021-07-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii .
Biochemistry, 60, 2021
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3AVH
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-05 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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7NWQ
 | | A carbohydrate binding module family 9 (CBM9) from Caldicellulosiruptor kristjanssonii in complex with cellotriose | | Descriptor: | 1,2-ETHANEDIOL, Beta-xylanase, CALCIUM ION, ... | | Authors: | Krska, D, Mazurkewich, S, Navarro Poulsen, J, Larsbrink, J, Lo Leggio, L. | | Deposit date: | 2021-03-17 | | Release date: | 2021-07-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.231 Å) | | Cite: | Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii .
Biochemistry, 60, 2021
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7NWO
 | | A carbohydrate binding module family 9 (CBM9) from Caldicellulosiruptor kristjanssonii in complex with glucose | | Descriptor: | 1,2-ETHANEDIOL, Beta-xylanase, CALCIUM ION, ... | | Authors: | Krska, D, Mazurkewich, S, Navarro Poulsen, J, Larsbrink, J, Lo Leggio, L. | | Deposit date: | 2021-03-17 | | Release date: | 2021-07-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii .
Biochemistry, 60, 2021
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3AVL
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-05 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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7SCE
 | | Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-2 octasaccharide substrate and co-factor product PAP | | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ADENOSINE-3'-5'-DIPHOSPHATE, Thioredoxin 1,Heparan sulfate glucosamine 3-O-sulfotransferase 5 | | Authors: | Wander, R, Kaminski, A.M, Krahn, J.M, Liu, J, Pedersen, L.C. | | Deposit date: | 2021-09-27 | | Release date: | 2022-01-19 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate
Acs Catalysis, 11, 2021
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2VJ6
 | | Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl)benzamide | | Descriptor: | BETA-SECRETASE 1, N-[(1S,2R)-1-benzyl-3-{[(1S)-2-(cyclohexylamino)-1-methyl-2-oxoethyl]amino}-2-hydroxypropyl]-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl)benzamide | | Authors: | Clarke, B, Demont, E, Dingwall, C, Dunsdon, R, Faller, A, Hawkins, J, Hussain, I, MacPherson, D, Maile, G, Matico, R, Milner, P, Mosley, J, Naylor, A, O'Brien, A, Redshaw, S, Riddell, D, Rowland, P, Soleil, V, Smith, K, Stanway, S, Stemp, G, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Ward, J, Wayne, G. | | Deposit date: | 2007-12-06 | | Release date: | 2008-01-29 | | Last modified: | 2019-05-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Bace-1 Inhibitors Part 2: Identification of Hydroxy Ethylamines (Heas) with Reduced Peptidic Character.
Bioorg.Med.Chem.Lett., 18, 2008
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7NWP
 | | A carbohydrate binding module family 9 (CBM9) from Caldicellulosiruptor kristjansonii in complex with cellobiose | | Descriptor: | 1,2-ETHANEDIOL, Beta-xylanase, CALCIUM ION, ... | | Authors: | Krska, D, Mazurkewich, S, Navarro Poulsen, J, Larsbrink, J, Lo Leggio, L. | | Deposit date: | 2021-03-17 | | Release date: | 2021-07-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.163 Å) | | Cite: | Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii .
Biochemistry, 60, 2021
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3AVA
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-02 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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3AVI
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-05 | | Release date: | 2012-02-15 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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3AV9
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-02 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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3AVF
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-05 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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3AVN
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-05 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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3AVB
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-02 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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3AVJ
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-05 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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3AVC
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-02 | | Release date: | 2012-01-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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3AVK
 | | Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | | Deposit date: | 2011-03-05 | | Release date: | 2012-01-18 | | Last modified: | 2013-06-19 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
Chembiochem, 12, 2011
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7SYJ
 | | Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 4(delta dII) | | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | | Deposit date: | 2021-11-25 | | Release date: | 2022-07-13 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Embo J., 41, 2022
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7SYL
 | | Structure of the HCV IRES bound to the 40S ribosomal subunit, closed conformation. Structure 6(delta dII) | | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | | Deposit date: | 2021-11-25 | | Release date: | 2022-07-13 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Embo J., 41, 2022
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7SYX
 | | Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII) | | Descriptor: | 18S rRNA, 40S ribosomal protein S24, 40S ribosomal protein S25, ... | | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | | Deposit date: | 2021-11-25 | | Release date: | 2022-07-13 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Embo J., 41, 2022
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