6DV0
 
 | | HIV-1 wild type protease with GRL-02815A, a thiochroman heterocycle with (S)-Boc-amine functionality as the P2 ligand | | 分子名称: | CHLORIDE ION, GLYCEROL, Protease, ... | | 著者 | Wang, Y.-F, Agniswamy, J, Weber, I.T. | | 登録日 | 2018-06-22 | | 公開日 | 2018-10-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.
Eur J Med Chem, 160, 2018
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6DYF
 | | Cu(II)-bound structure of the engineered cyt cb562 variant, CH3Y | | 分子名称: | CHLORIDE ION, COPPER (II) ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Tezcan, F.A, Rittle, J. | | 登録日 | 2018-07-01 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | An efficient, step-economical strategy for the design of functional metalloproteins.
Nat.Chem., 11, 2019
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6DYH
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6DYN
 | | C-terminal condensation domain of Ebony in complex with Histamine | | 分子名称: | CALCIUM ION, Ebony, HISTAMINE | | 著者 | Izore, T, Tailhades, J, Hansen, M.H, Kaczmarski, J.A, Jackson, C.J, Cryle, M.J. | | 登録日 | 2018-07-02 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | | 主引用文献 | Drosophila melanogasternonribosomal peptide synthetase Ebony encodes an atypical condensation domain.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6DYS
 | | C-terminal condensation domain of Ebony in complex with beta-alanyl-dopamine | | 分子名称: | CALCIUM ION, Ebony, N-[2-(3,4-dihydroxyphenyl)ethyl]-beta-alaninamide | | 著者 | Izore, T, Tailhades, J, Hansen, M.H, Kaczmarski, J.A, Jackson, C.J, Cryle, M.J. | | 登録日 | 2018-07-02 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Drosophila melanogasternonribosomal peptide synthetase Ebony encodes an atypical condensation domain.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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1G2S
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6DYK
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1G2Z
 | | DIMERIZATION DOMAIN OF HNF-1ALPHA WITH A LEU 13 SELENOMETHIONINE SUBSTITUTION | | 分子名称: | HEPATOCYTE NUCLEAR FACTOR 1-ALPHA | | 著者 | Rose, R.B, Endrizzi, J.A, Cronk, J.D, Holton, J, Alber, T. | | 登録日 | 2000-10-23 | | 公開日 | 2001-01-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | High-resolution structure of the HNF-1alpha dimerization domain.
Biochemistry, 39, 2000
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1AH1
 | | CTLA-4, NMR, 20 STRUCTURES | | 分子名称: | CTLA-4, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Metzler, W.J, Bajorath, J, Fenderson, W, Shaw, S.-Y, Peach, R, Constantine, K.L, Naemura, J, Leytze, G, Lavoie, T.B, Mueller, L, Linsley, P.S. | | 登録日 | 1997-04-11 | | 公開日 | 1998-04-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.
Nat.Struct.Biol., 4, 1997
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6E0I
 | | Crystal structure of Glucokinase in complex with compound 72 | | 分子名称: | 1-{4-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-[(pyridin-2-yl)sulfanyl]pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]piperidin-1 -yl}ethan-1-one, DIMETHYL SULFOXIDE, Glucokinase, ... | | 著者 | Hinklin, R.J, Baer, B.R, Boyd, S.A, Chicarelli, M.D, Condroski, K.R, DeWolf, W.E, Fischer, J, Frank, M, Hingorani, G.P, Lee, P.A, Neitzel, N.A, Pratt, S.A, Singh, A, Sullivan, F.X, Turner, T, Voegtli, W.C, Wallace, E.M, Williams, L, Aicher, T.D. | | 登録日 | 2018-07-06 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Bioorg.Med.Chem., 28, 2020
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1G3X
 | | INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER | | 分子名称: | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, N(ALPHA)-(9-ACRIDINOYL)-TETRAARGININE-AMIDE | | 著者 | Malinina, L, Soler-Lopez, M, Aymami, J, Subirana, J.A. | | 登録日 | 2000-10-25 | | 公開日 | 2002-08-16 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Intercalation of an acridine-peptide drug in an AA/TT base step in the crystal structure of [d(CGCGAATTCGCG)](2) with six duplexes and seven Mg(2+) ions in the asymmetric unit.
Biochemistry, 41, 2002
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6DY4
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6DY8
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6DYI
 | | Co(II)-bound structure of the engineered cyt cb562 variant, H3 | | 分子名称: | CALCIUM ION, CHLORIDE ION, COBALT (II) ION, ... | | 著者 | Tezcan, F.A, Rittle, J. | | 登録日 | 2018-07-01 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.964 Å) | | 主引用文献 | An efficient, step-economical strategy for the design of functional metalloproteins.
Nat.Chem., 11, 2019
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6DYO
 | | C-terminal condensation domain of Ebony in complex with L-Dopamine | | 分子名称: | CALCIUM ION, Ebony, L-DOPAMINE | | 著者 | Izore, T, Tailhades, J, Hansen, M.H, Kaczmarski, J.A, Jackson, C.J, Cryle, M.J. | | 登録日 | 2018-07-02 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Drosophila melanogasternonribosomal peptide synthetase Ebony encodes an atypical condensation domain.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6DYB
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6DYJ
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6E1R
 | | Crystal structure of the Acinetobacter phage vB_ApiP_P1 tailspike protein | | 分子名称: | CHLORIDE ION, SODIUM ION, Tailspike protein | | 著者 | Plattner, M, Shneider, M.M, Oliveira, H, Azeredo, J, Leiman, P.G. | | 登録日 | 2018-07-10 | | 公開日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.693 Å) | | 主引用文献 | Crystal structure of the Acinetobacter phage vB_ApiP_P1 tailspike protein
To Be Published
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6DYC
 | | Co(II)-bound structure of the engineered cyt cb562 variant, CH3 | | 分子名称: | CALCIUM ION, COBALT (II) ION, HEME C, ... | | 著者 | Tezcan, F.A, Rittle, J. | | 登録日 | 2018-07-01 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | An efficient, step-economical strategy for the design of functional metalloproteins.
Nat.Chem., 11, 2019
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6DYD
 | | Cu(II)-bound structure of the engineered cyt cb562 variant, CH3 | | 分子名称: | CALCIUM ION, COPPER (II) ION, HEME C, ... | | 著者 | Tezcan, F.A, Rittle, J. | | 登録日 | 2018-07-01 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.724 Å) | | 主引用文献 | An efficient, step-economical strategy for the design of functional metalloproteins.
Nat.Chem., 11, 2019
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6DYM
 | | C-terminal condensation domain of Ebony | | 分子名称: | CALCIUM ION, Ebony | | 著者 | Izore, T, Tailhades, J, Hansen, M.H, Kaczmarski, J.A, Jackson, C.J, Cryle, M.J. | | 登録日 | 2018-07-02 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Drosophila melanogasternonribosomal peptide synthetase Ebony encodes an atypical condensation domain.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6DYR
 | | C-terminal condensation domain of Ebony in complex with Carcinine | | 分子名称: | Ebony, N-[2-(1H-imidazol-5-yl)ethyl]-beta-alaninamide | | 著者 | Izore, T, Tailhades, J, Hansen, M.H, Kaczmarski, J.A, Jackson, C.J, Cryle, M.J. | | 登録日 | 2018-07-02 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Drosophila melanogasternonribosomal peptide synthetase Ebony encodes an atypical condensation domain.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6DY6
 | | Mn(II)-bound structure of the engineered cyt cb562 variant, CH2E | | 分子名称: | HEME C, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ... | | 著者 | Tezcan, F.A, Rittle, J. | | 登録日 | 2018-07-01 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | An efficient, step-economical strategy for the design of functional metalloproteins.
Nat.Chem., 11, 2019
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6DYE
 | | Fe(II)-bound structure of the engineered cyt cb562 variant, CH3 | | 分子名称: | CALCIUM ION, FE (III) ION, HEME C, ... | | 著者 | Tezcan, F.A, Rittle, J. | | 登録日 | 2018-07-01 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | An efficient, step-economical strategy for the design of functional metalloproteins.
Nat.Chem., 11, 2019
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6DYL
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