8C1V
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![BU of 8c1v by Molmil](/molmil-images/mine/8c1v) | SARS-CoV-2 S-trimer (3 RBDs up) bound to TriSb92, fitted into cryo-EM map | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sb92, ... | Authors: | Huiskonen, J.T, Rissanen, I, Hannula, L. | Deposit date: | 2022-12-21 | Release date: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants. Nat Commun, 14, 2023
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5OXE
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![BU of 5oxe by Molmil](/molmil-images/mine/5oxe) | |
5K47
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![BU of 5k47 by Molmil](/molmil-images/mine/5k47) | CryoEM structure of the human Polycystin-2/PKD2 TRP channel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | Authors: | Pike, A.C.W, Grieben, M, Shintre, C.A, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2016-05-20 | Release date: | 2016-08-24 | Last modified: | 2020-10-21 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). Nat. Struct. Mol. Biol., 24, 2017
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5ACA
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![BU of 5aca by Molmil](/molmil-images/mine/5aca) | Structure-based energetics of protein interfaces guide Foot-and-Mouth disease virus vaccine design | Descriptor: | VP1, VP2, VP3, ... | Authors: | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, Perez-Martin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | Deposit date: | 2015-08-14 | Release date: | 2015-09-23 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure-Based Energetics of Protein Interfaces Guide Foot-and-Mouth Disease Vaccine Design Nat.Struct.Mol.Biol., 22, 2015
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6GYN
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![BU of 6gyn by Molmil](/molmil-images/mine/6gyn) | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Shintre, C.A, Pike, A.C.W, Tessitore, A, Young, M, Bushell, S.R, Strain-Damerell, C, Mukhopadhyay, S, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2018-06-30 | Release date: | 2019-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel To Be Published
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6GYO
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![BU of 6gyo by Molmil](/molmil-images/mine/6gyo) | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Shintre, C.A, Pike, A.C.W, Tessitore, A, Young, M, Bushell, S.R, Strain-Damerell, C, Mukhopadhyay, S, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2018-06-30 | Release date: | 2019-05-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel To Be Published
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7Q8B
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![BU of 7q8b by Molmil](/molmil-images/mine/7q8b) | Leishmania major actin filament in ADP-Pi state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION, ... | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | Deposit date: | 2021-11-11 | Release date: | 2022-05-18 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite. Nat Commun, 13, 2022
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7Q8C
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![BU of 7q8c by Molmil](/molmil-images/mine/7q8c) | Leishmania major actin filament in ADP-state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | Deposit date: | 2021-11-11 | Release date: | 2022-05-18 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite. Nat Commun, 13, 2022
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7Q8S
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![BU of 7q8s by Molmil](/molmil-images/mine/7q8s) | Leishmania major ADP-actin filament decorated with Leishmania major cofilin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADF/Cofilin, Actin, ... | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | Deposit date: | 2021-11-11 | Release date: | 2022-05-18 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite. Nat Commun, 13, 2022
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7B0A
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![BU of 7b0a by Molmil](/molmil-images/mine/7b0a) | Puumala virus-like particle glycoprotein spike and lattice contacts model. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, ... | Authors: | Rissanen, I, Stass, R, Huiskonen, J.T, Bowden, T.A. | Deposit date: | 2020-11-19 | Release date: | 2020-12-16 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (13.9 Å) | Cite: | Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein. Elife, 9, 2020
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7B09
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![BU of 7b09 by Molmil](/molmil-images/mine/7b09) | Puumala virus glycoprotein (Gc) in complex with fab fragment P-4G2. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, ... | Authors: | Rissanen, I, Stass, R, Huiskonen, J.T, Bowden, T.A. | Deposit date: | 2020-11-19 | Release date: | 2020-12-16 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (13.4 Å) | Cite: | Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein. Elife, 9, 2020
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8BI4
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![BU of 8bi4 by Molmil](/molmil-images/mine/8bi4) | |
6HY0
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![BU of 6hy0 by Molmil](/molmil-images/mine/6hy0) | Atomic models of P1, P4 C-terminal fragment and P8 fitted in the bacteriophage phi6 nucleocapsid reconstructed with icosahedral symmetry | Descriptor: | Major Outer Capsid Protein P8, Major inner protein P1, Packaging Enzyme P4 | Authors: | El Omari, K, Ilca, S.L, Stuart, D.I, Huiskonen, J.T. | Deposit date: | 2018-10-18 | Release date: | 2019-06-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus. Nature, 570, 2019
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6J7V
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![BU of 6j7v by Molmil](/molmil-images/mine/6j7v) | |
8P0W
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![BU of 8p0w by Molmil](/molmil-images/mine/8p0w) | Structure of the human Commander complex COMMD ring | Descriptor: | COMM domain-containing protein 1, COMM domain-containing protein 10, COMM domain-containing protein 2, ... | Authors: | Kumpula, E.P, Laulumaa, S, Huiskonen, J.T. | Deposit date: | 2023-05-11 | Release date: | 2024-03-20 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure and interactions of the endogenous human Commander complex. Nat.Struct.Mol.Biol., 31, 2024
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8P0X
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![BU of 8p0x by Molmil](/molmil-images/mine/8p0x) | Structure of the human Commander complex Retriever Subcomplex | Descriptor: | Coiled-coil domain-containing protein 22, Coiled-coil domain-containing protein 93, VPS35 endosomal protein-sorting factor-like, ... | Authors: | Kumpula, E.P, Laulumaa, S, Huiskonen, J.T. | Deposit date: | 2023-05-11 | Release date: | 2024-03-20 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (7.5 Å) | Cite: | Structure and interactions of the endogenous human Commander complex. Nat.Struct.Mol.Biol., 31, 2024
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8P0V
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![BU of 8p0v by Molmil](/molmil-images/mine/8p0v) | Structure of the human Commander complex coiled coils, DENND10 and partial Retriever subcomplex | Descriptor: | Coiled-coil domain-containing protein 22, Coiled-coil domain-containing protein 93, DENN domain-containing protein 10, ... | Authors: | Kumpula, E.P, Laulumaa, S, Huiskonen, J.T. | Deposit date: | 2023-05-10 | Release date: | 2024-03-20 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Structure and interactions of the endogenous human Commander complex. Nat.Struct.Mol.Biol., 31, 2024
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4BOM
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![BU of 4bom by Molmil](/molmil-images/mine/4bom) | Structure of herpesvirus fusion glycoprotein B-bilayer complex revealing the protein-membrane and lateral protein-protein interaction | Descriptor: | ENVELOPE GLYCOPROTEIN B | Authors: | Maurer, U.E, Zeev-Ben-Mordehai, Z, Pandurangan, A.P, Cairns, T.M, Hannah, B.P, Whitbeck, J.C, Eisenberg, R.J, Cohen, G.H, Topf, M, Huiskonen, J.T, Grunewald, K. | Deposit date: | 2013-05-21 | Release date: | 2013-07-31 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (27 Å) | Cite: | The structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction. Structure, 21, 2013
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4C53
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![BU of 4c53 by Molmil](/molmil-images/mine/4c53) | Crystal Structure of Guanarito virus GP2 in the post-fusion conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PRE-GLYCOPROTEIN POLYPROTEIN GP COMPLEX, ... | Authors: | Parsy, M, Huiskonen, J.T, Harlos, K, Bowden, T.A. | Deposit date: | 2013-09-10 | Release date: | 2013-10-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.14 Å) | Cite: | Crystal Structure of Venezuelan Hemorrhagic Fever Virus Fusion Glycoprotein Reveals a Class 1 Post-Fusion Architecture with Extensive Glycosylation. J.Virol., 87, 2013
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5OPG
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![BU of 5opg by Molmil](/molmil-images/mine/5opg) | Structure of the Hantaan virus Gn glycoprotein ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | Authors: | Rissanen, I, Stass, R, Zeltina, A, Li, S, Hepojoki, J, Harlos, K, Gilbert, R.J.C, Huiskonen, J.T, Bowden, T.A. | Deposit date: | 2017-08-09 | Release date: | 2017-08-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope. J. Virol., 91, 2017
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5AC9
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![BU of 5ac9 by Molmil](/molmil-images/mine/5ac9) | Structure-based energetics of protein interfaces guide Foot-and-Mouth disease virus vaccine design | Descriptor: | VP1, VP2, VP3, ... | Authors: | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, PerezMartin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | Deposit date: | 2015-08-14 | Release date: | 2015-09-23 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure-Based Energetics of Protein Interfaces Guide Foot-and-Mouth Disease Vaccine Design Nat.Struct.Mol.Biol., 22, 2015
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5D8A
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![BU of 5d8a by Molmil](/molmil-images/mine/5d8a) | Crystal structure of recombinant foot-and-mouth-disease virus A22-H2093F empty capsid | Descriptor: | VP1, VP2, VP3, ... | Authors: | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, Perez-Martin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | Deposit date: | 2015-08-16 | Release date: | 2015-09-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design. Nat.Struct.Mol.Biol., 22, 2015
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5DDJ
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![BU of 5ddj by Molmil](/molmil-images/mine/5ddj) | Crystal structure of recombinant foot-and-mouth-disease virus O1M-S2093Y empty capsid | Descriptor: | Foot and mouth disease virus, VP1, VP2, ... | Authors: | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, Perez-Martin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | Deposit date: | 2015-08-25 | Release date: | 2015-09-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design. Nat.Struct.Mol.Biol., 22, 2015
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1YQ5
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![BU of 1yq5 by Molmil](/molmil-images/mine/1yq5) | PRD1 vertex protein P5 | Descriptor: | Minor capsid protein | Authors: | Merckel, M.C, Huiskonen, J.T, Goldman, A, Bamford, D.H, Tuma, R. | Deposit date: | 2005-02-01 | Release date: | 2005-04-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture. Mol.Cell, 18, 2005
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1YQ8
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![BU of 1yq8 by Molmil](/molmil-images/mine/1yq8) | PRD1 vertex protein P5 | Descriptor: | Minor capsid protein | Authors: | Merckel, M.C, Huiskonen, J.T, Goldman, A, Bamford, D.H, Tuma, R. | Deposit date: | 2005-02-01 | Release date: | 2005-04-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture. Mol.Cell, 18, 2005
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