8C1V
 
 | | SARS-CoV-2 S-trimer (3 RBDs up) bound to TriSb92, fitted into cryo-EM map | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sb92, ... | | Authors: | Huiskonen, J.T, Rissanen, I, Hannula, L. | | Deposit date: | 2022-12-21 | | Release date: | 2023-04-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants.
Nat Commun, 14, 2023
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5OXE
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7NKS
 | | Structure of the Hantaan virus Gn glycoprotein ectodomain in complex with Fab HTN-Gn1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, Fab HTN-Gn1 heavy chain, ... | | Authors: | Rissanen, I, Bowden, T.A, Huiskonen, J.T, Stass, R. | | Deposit date: | 2021-02-18 | | Release date: | 2021-06-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen.
Mbio, 12, 2021
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5OPG
 | | Structure of the Hantaan virus Gn glycoprotein ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | | Authors: | Rissanen, I, Stass, R, Zeltina, A, Li, S, Hepojoki, J, Harlos, K, Gilbert, R.J.C, Huiskonen, J.T, Bowden, T.A. | | Deposit date: | 2017-08-09 | | Release date: | 2017-08-23 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope.
J. Virol., 91, 2017
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5K47
 | | CryoEM structure of the human Polycystin-2/PKD2 TRP channel | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | | Authors: | Pike, A.C.W, Grieben, M, Shintre, C.A, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | Deposit date: | 2016-05-20 | | Release date: | 2016-08-24 | | Last modified: | 2020-10-21 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Nat. Struct. Mol. Biol., 24, 2017
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7Q8S
 | | Leishmania major ADP-actin filament decorated with Leishmania major cofilin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADF/Cofilin, Actin, ... | | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | | Deposit date: | 2021-11-11 | | Release date: | 2022-05-18 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.
Nat Commun, 13, 2022
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8P0V
 | | Structure of the human Commander complex coiled coils, DENND10 and partial Retriever subcomplex | | Descriptor: | Coiled-coil domain-containing protein 22, Coiled-coil domain-containing protein 93, DENN domain-containing protein 10, ... | | Authors: | Kumpula, E.P, Laulumaa, S, Huiskonen, J.T. | | Deposit date: | 2023-05-10 | | Release date: | 2024-03-20 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (6.5 Å) | | Cite: | Structure and interactions of the endogenous human Commander complex.
Nat.Struct.Mol.Biol., 31, 2024
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7Q8B
 | | Leishmania major actin filament in ADP-Pi state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION, ... | | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | | Deposit date: | 2021-11-11 | | Release date: | 2022-05-18 | | Last modified: | 2022-06-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.
Nat Commun, 13, 2022
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7Q8C
 | | Leishmania major actin filament in ADP-state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, MAGNESIUM ION | | Authors: | Kotila, T, Muniyandi, S, Lappalainen, P, Huiskonen, J.T. | | Deposit date: | 2021-11-11 | | Release date: | 2022-05-18 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.
Nat Commun, 13, 2022
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1GW8
 | | quasi-atomic resolution model of bacteriophage PRD1 sus607 mutant, obtained by combined cryo-EM and X-ray crystallography. | | Descriptor: | MAJOR CAPSID PROTEIN | | Authors: | San Martin, C, Huiskonen, J, Bamford, J.K.H, Butcher, S.J, Fuller, S.D, Bamford, D.H, Burnett, R.M. | | Deposit date: | 2002-03-08 | | Release date: | 2002-03-15 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (13.3 Å) | | Cite: | Minor Proteins, Mobile Arms and Membrane-Capsid Interactions in the Bacteriophage Prd1 Capsid.
Nat.Struct.Biol., 9, 2002
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1YQ5
 | | PRD1 vertex protein P5 | | Descriptor: | Minor capsid protein | | Authors: | Merckel, M.C, Huiskonen, J.T, Goldman, A, Bamford, D.H, Tuma, R. | | Deposit date: | 2005-02-01 | | Release date: | 2005-04-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture.
Mol.Cell, 18, 2005
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7B0A
 | | Puumala virus-like particle glycoprotein spike and lattice contacts model. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, ... | | Authors: | Rissanen, I, Stass, R, Huiskonen, J.T, Bowden, T.A. | | Deposit date: | 2020-11-19 | | Release date: | 2020-12-16 | | Last modified: | 2021-01-13 | | Method: | ELECTRON MICROSCOPY (13.9 Å) | | Cite: | Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein.
Elife, 9, 2020
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7B09
 | | Puumala virus glycoprotein (Gc) in complex with fab fragment P-4G2. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, ... | | Authors: | Rissanen, I, Stass, R, Huiskonen, J.T, Bowden, T.A. | | Deposit date: | 2020-11-19 | | Release date: | 2020-12-16 | | Last modified: | 2021-01-13 | | Method: | ELECTRON MICROSCOPY (13.4 Å) | | Cite: | Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein.
Elife, 9, 2020
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5D8A
 | | Crystal structure of recombinant foot-and-mouth-disease virus A22-H2093F empty capsid | | Descriptor: | VP1, VP2, VP3, ... | | Authors: | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, Perez-Martin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | | Deposit date: | 2015-08-16 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Nat.Struct.Mol.Biol., 22, 2015
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5DDJ
 | | Crystal structure of recombinant foot-and-mouth-disease virus O1M-S2093Y empty capsid | | Descriptor: | Foot and mouth disease virus, VP1, VP2, ... | | Authors: | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, Perez-Martin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | | Deposit date: | 2015-08-25 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Nat.Struct.Mol.Biol., 22, 2015
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8P0W
 | | Structure of the human Commander complex COMMD ring | | Descriptor: | COMM domain-containing protein 1, COMM domain-containing protein 10, COMM domain-containing protein 2, ... | | Authors: | Kumpula, E.P, Laulumaa, S, Huiskonen, J.T. | | Deposit date: | 2023-05-11 | | Release date: | 2024-03-20 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure and interactions of the endogenous human Commander complex.
Nat.Struct.Mol.Biol., 31, 2024
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5AC9
 | | Structure-based energetics of protein interfaces guide Foot-and-Mouth disease virus vaccine design | | Descriptor: | VP1, VP2, VP3, ... | | Authors: | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, PerezMartin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | | Deposit date: | 2015-08-14 | | Release date: | 2015-09-23 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure-Based Energetics of Protein Interfaces Guide Foot-and-Mouth Disease Vaccine Design
Nat.Struct.Mol.Biol., 22, 2015
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8P0X
 | | Structure of the human Commander complex Retriever Subcomplex | | Descriptor: | Coiled-coil domain-containing protein 22, Coiled-coil domain-containing protein 93, VPS35 endosomal protein-sorting factor-like, ... | | Authors: | Kumpula, E.P, Laulumaa, S, Huiskonen, J.T. | | Deposit date: | 2023-05-11 | | Release date: | 2024-03-20 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Structure and interactions of the endogenous human Commander complex.
Nat.Struct.Mol.Biol., 31, 2024
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5ACA
 | | Structure-based energetics of protein interfaces guide Foot-and-Mouth disease virus vaccine design | | Descriptor: | VP1, VP2, VP3, ... | | Authors: | Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, Perez-Martin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. | | Deposit date: | 2015-08-14 | | Release date: | 2015-09-23 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure-Based Energetics of Protein Interfaces Guide Foot-and-Mouth Disease Vaccine Design
Nat.Struct.Mol.Biol., 22, 2015
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1GW7
 | | QUASI-ATOMIC RESOLUTION MODEL OF BACTERIOPHAGE PRD1 CAPSID, OBTAINED BY COMBINED CRYO-EM AND X-RAY CRYSTALLOGRAPHY. | | Descriptor: | MAJOR CAPSID PROTEIN | | Authors: | San Martin, C, Huiskonen, J, Bamford, J.K.H, Butcher, S.J, Fuller, S.D, Bamford, D.H, Burnett, R.M. | | Deposit date: | 2002-03-08 | | Release date: | 2002-03-13 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (13.5 Å) | | Cite: | Minor Proteins, Mobile Arms, and Membrane-Capsid Interactions in Bacteriophage Prd1 Capsid Assembly
Nat.Struct.Biol., 9, 2002
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7NVL
 | | Human TRiC complex in closed state with nanobody bound (Consensus Map) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W, Structural Genomics Consortium (SGC) | | Deposit date: | 2021-03-15 | | Release date: | 2022-03-02 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Nat.Struct.Mol.Biol., 29, 2022
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7NVN
 | | Human TRiC complex in closed state with nanobody and tubulin bound | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W. | | Deposit date: | 2021-03-15 | | Release date: | 2022-03-02 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Nat.Struct.Mol.Biol., 29, 2022
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7NVO
 | | Human TRiC complex in open state with nanobody bound | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W. | | Deposit date: | 2021-03-15 | | Release date: | 2022-03-02 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Nat.Struct.Mol.Biol., 29, 2022
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7NVM
 | | Human TRiC complex in closed state with nanobody Nb18, actin and PhLP2A bound | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Actin, ... | | Authors: | Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W, Structural Genomics Consortium (SGC) | | Deposit date: | 2021-03-15 | | Release date: | 2022-03-02 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Nat.Struct.Mol.Biol., 29, 2022
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6HY0
 | | Atomic models of P1, P4 C-terminal fragment and P8 fitted in the bacteriophage phi6 nucleocapsid reconstructed with icosahedral symmetry | | Descriptor: | Major Outer Capsid Protein P8, Major inner protein P1, Packaging Enzyme P4 | | Authors: | El Omari, K, Ilca, S.L, Stuart, D.I, Huiskonen, J.T. | | Deposit date: | 2018-10-18 | | Release date: | 2019-06-12 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus.
Nature, 570, 2019
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