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PDB: 10 件

4WGI
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A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)
分子名称: (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, FORMIC ACID, MAGNESIUM ION, ...
著者Clifton, M.C, Fairman, J.W, Fang, C, D'Souza, B, Fulroth, B, Leed, A, McCarren, P, Wang, L, Wang, Y, Kaushik, V, Palmer, M, Wei, G, Golub, T.R, Hubbard, B.K, Serrano-Wu, M.H.
登録日2014-09-18
公開日2014-11-19
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
Acs Med.Chem.Lett., 5, 2014
1EC9
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E. COLI GLUCARATE DEHYDRATASE BOUND TO XYLAROHYDROXAMATE
分子名称: GLUCARATE DEHYDRATASE, ISOPROPYL ALCOHOL, MAGNESIUM ION, ...
著者Gulick, A.M, Hubbard, B.K, Gerlt, J.A, Rayment, I.
登録日2000-01-25
公開日2000-05-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli.
Biochemistry, 39, 2000
1EC8
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E. COLI GLUCARATE DEHYDRATASE BOUND TO PRODUCT 2,3-DIHYDROXY-5-OXO-HEXANEDIOATE
分子名称: 2,3-DIHYDROXY-5-OXO-HEXANEDIOATE, GLUCARATE DEHYDRATASE, ISOPROPYL ALCOHOL, ...
著者Gulick, A.M, Hubbard, B.K, Gerlt, J.A, Rayment, I.
登録日2000-01-25
公開日2000-05-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli.
Biochemistry, 39, 2000
3P5C
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The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
分子名称: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9
著者Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A.
登録日2010-10-08
公開日2011-10-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
3P5B
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BU of 3p5b by Molmil
The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation
分子名称: CALCIUM ION, Low density lipoprotein receptor variant, Proprotein convertase subtilisin/kexin type 9
著者Lo Surdo, P, Bottomley, M.J, Calzetta, A, Settembre, E.C, Cirillo, A, Pandit, S, Ni, Y, Hubbard, B, Sitlani, A, Carfi, A.
登録日2010-10-08
公開日2011-10-26
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
Embo Rep., 12, 2011
1JCT
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Glucarate Dehydratase, N341L mutant Orthorhombic Form
分子名称: D-GLUCARATE, Glucarate Dehydratase, ISOPROPYL ALCOHOL, ...
著者Gulick, A.M, Hubbard, B.K, Gerlt, J.A, Rayment, I.
登録日2001-06-11
公開日2001-09-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli.
Biochemistry, 40, 2001
1JDF
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Glucarate Dehydratase from E.coli N341D mutant
分子名称: 2,3-DIHYDROXY-5-OXO-HEXANEDIOATE, Glucarate Dehydratase, ISOPROPYL ALCOHOL, ...
著者Gulick, A.M, Hubbard, B.K, Gerlt, J.A, Rayment, I.
登録日2001-06-13
公開日2001-09-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli.
Biochemistry, 40, 2001
1ECQ
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E. COLI GLUCARATE DEHYDRATASE BOUND TO 4-DEOXYGLUCARATE
分子名称: 4-DEOXYGLUCARATE, GLUCARATE DEHYDRATASE, ISOPROPYL ALCOHOL, ...
著者Gulick, A.M, Hubbard, B.K, Gerlt, J.A, Rayment, I.
登録日2000-01-25
公開日2000-05-23
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli.
Biochemistry, 39, 2000
1EC7
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E. COLI GLUCARATE DEHYDRATASE NATIVE ENZYME
分子名称: GLUCARATE DEHYDRATASE, ISOPROPYL ALCOHOL, MAGNESIUM ION
著者Gulick, A.M, Hubbard, B.K, Gerlt, J.A, Rayment, I.
登録日2000-01-25
公開日2000-05-23
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli.
Biochemistry, 39, 2000
3CXO
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Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and 3-deoxy-L-rhamnonate
分子名称: (2R,4S)-2,4,7-trihydroxyheptanoic acid, 3,6-dideoxy-L-arabino-hexonic acid, MAGNESIUM ION, ...
著者Fedorov, A.A, Fedorov, E.V, Rakus, J.F, Hubbard, B.K, Gerlt, J.A, Almo, S.C.
登録日2008-04-24
公開日2008-09-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase.
Biochemistry, 47, 2008

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件を2024-07-17に公開中

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