8T7D
 
 | | Crystal structure of wild type IDH1 bound to compound 1 | | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide | | Authors: | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | | Deposit date: | 2023-06-20 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (3.444 Å) | | Cite: | Mechanistic and Biostructural Studies of Mutant IDH1
To Be Published
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8T7O
 | | Crystal structure of the R132H mutant of IDH1 bound to AG-120 | | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ivosidenib | | Authors: | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | | Deposit date: | 2023-06-20 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.053 Å) | | Cite: | Mechanistic and Biostructural Studies of Mutant IDH1
To Be Published
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8T7N
 | | Crystal structure of the R132H mutant of IDH1 bound to compound 1 | | Descriptor: | Isocitrate dehydrogenase [NADP] cytoplasmic, N-(4-tert-butylphenyl)-7,8-dimethyl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepine-6-carboxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Lu, J, Abeywickrema, P, Heo, M.R, Parthasarathy, G, McCoy, M, Soisson, S.M. | | Deposit date: | 2023-06-20 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Mechanistic and Biostructural Studies of Mutant IDH1
To Be Published
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8VQ2
 | | HSV1 polymerase ternary complex with dsDNA and compound 44 | | Descriptor: | 2-(4-bromophenyl)-N-(3-methoxy-4-{[(4S)-2-oxo-1,3-oxazolidin-4-yl]methyl}phenyl)acetamide, DNA (5'-D(P*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*T)-3'), ... | | Authors: | Hayes, R.P, Heo, M.R, Plotkin, M. | | Deposit date: | 2024-01-17 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (3.829 Å) | | Cite: | Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.
Acs Med.Chem.Lett., 15, 2024
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