8QSZ
 
 | | Structure of s. pombe RNA polymerase II in complex with DSIF and Rat1/Rai1 | | Descriptor: | 5'-3' exoribonuclease 2, DNA none template (34-MER), DNA template (40-MER), ... | | Authors: | Carrique, L, Kus, K, Vasiljeva, L, Grimes, J.M. | | Deposit date: | 2023-10-12 | | Release date: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.67 Å) | | Cite: | DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts.
To Be Published
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5FVD
 | | Human metapneumovirus N0-P complex | | Descriptor: | CHLORIDE ION, NUCLEOCAPSID, PHOSPHOPROTEIN | | Authors: | Renner, M, Bertinelli, M, Leyrat, C, Paesen, G.C, Saraiva de Oliveira, L.F, Huiskonen, J.T, Grimes, J.M. | | Deposit date: | 2016-02-05 | | Release date: | 2016-02-24 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein.
Elife, 5, 2016
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8R1J
 | | Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B. | | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2023-11-02 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.
Nat Commun, 15, 2024
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5FVC
 | | Structure of RNA-bound decameric HMPV nucleoprotein | | Descriptor: | HMPV NUCLEOPROTEIN, RNA | | Authors: | Renner, M, Bertinelli, M, Leyrat, C, Paesen, G.C, Saraiva de Oliveira, L.F, Huiskonen, J.T, Grimes, J.M. | | Deposit date: | 2016-02-05 | | Release date: | 2016-02-24 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (4.17 Å) | | Cite: | Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein.
Elife, 5, 2016
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2CME
 | | The crystal structure of SARS coronavirus ORF-9b protein | | Descriptor: | DECANE, HYPOTHETICAL PROTEIN 5 | | Authors: | Meier, C, Aricescu, A.R, Assenberg, R, Aplin, R.T, Gilbert, R.J.C, Grimes, J.M, Stuart, D.I. | | Deposit date: | 2006-05-06 | | Release date: | 2006-07-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Crystal Structure of Orf-9B, a Lipid Binding Protein from the Sars Coronavirus.
Structure, 14, 2006
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8BS7
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8BCK
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8BC5
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8BCL
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8BBT
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6QX3
 | | Influenza A virus (A/NT/60/1968) polymerase Hetermotrimer in complex with 3'5' cRNA promoter and Nb8205 | | Descriptor: | Nb8205, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Carrique, L, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-04 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Nature, 573, 2019
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6S5V
 | | Crystal structure of the Cap-Midlink region of the H5N1 Influenza A virus polymerase in complex with a Cap-domain binding analogue | | Descriptor: | (1~{S},2~{S},3~{S},6~{R})-2-[[2-[5,7-bis(fluoranyl)-1~{H}-indol-3-yl]-5-fluoranyl-pyrimidin-4-yl]amino]-3,6-dimethyl-cyclohexane-1-carboxylic acid, GLYCEROL, POTASSIUM ION, ... | | Authors: | Keown, J.R, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-07-02 | | Release date: | 2019-11-06 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region.
J.Med.Chem., 62, 2019
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6RR7
 | | Influenza A virus (A/NT/60/1968) polymerase Heterotrimer bound to 3'5' vRNA promoter and capped RNA primer | | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D(*(M7G))-R(P*AP*AP*UP*CP*U)-3'), ... | | Authors: | Carrique, L, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-05-17 | | Release date: | 2019-09-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Nature, 573, 2019
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4UOI
 | | Unexpected structure for the N-terminal domain of Hepatitis C virus envelope glycoprotein E1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GENOME POLYPROTEIN | | Authors: | El Omari, K, Iourin, O, Kadlec, J, Harlos, K, Grimes, J.M, Stuart, D.I. | | Deposit date: | 2014-06-04 | | Release date: | 2014-08-20 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.49 Å) | | Cite: | Unexpected Structure for the N-Terminal Domain of Hepatitis C Virus Envelope Glycoprotein E1
Acta Crystallogr.,Sect.D, 70, 2014
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5OIY
 | | Structure of the HMPV P oligomerization domain at 2.2 A | | Descriptor: | Phosphoprotein | | Authors: | Renner, M, Paesen, G.C, Grison, C.M, Granier, S, Grimes, J.M, Leyrat, C. | | Deposit date: | 2017-07-19 | | Release date: | 2017-11-15 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering.
Sci Rep, 7, 2017
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2PX4
 | | Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH (Monoclinic form 2) | | Descriptor: | CHLORIDE ION, GLYCEROL, Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], ... | | Authors: | Assenberg, R, Ren, J, Verma, A, Walter, T.S, Alderton, D, Hurrelbrink, R.J, Fuller, S.D, Owens, R.J, Stuart, D.I, Grimes, J.M, Oxford Protein Production Facility (OPPF) | | Deposit date: | 2007-05-14 | | Release date: | 2007-05-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
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2PX5
 | | Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH (Orthorhombic crystal form) | | Descriptor: | Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION | | Authors: | Assenberg, R, Ren, J, Verma, A, Walter, T.S, Alderton, D, Hurrelbrink, R.J, Fuller, S.D, Owens, R.J, Stuart, D.I, Grimes, J.M, Oxford Protein Production Facility (OPPF) | | Deposit date: | 2007-05-14 | | Release date: | 2007-05-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.
J.Gen.Virol., 88, 2007
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5A1M
 | | Crystal structure of calcium-bound human adseverin domain A3 | | Descriptor: | ADSEVERIN, CALCIUM ION | | Authors: | Chumnarnsilpa, S, Robinson, R.C, Grimes, J.M, Leyrat, C. | | Deposit date: | 2015-05-01 | | Release date: | 2015-09-16 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Calcium-Controlled Conformational Choreography in the N-Terminal Half of Adseverin.
Nat.Commun., 6, 2015
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5ABJ
 | | Structure of Coxsackievirus A16 in complex with GPP3 | | Descriptor: | 1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE, CHLORIDE ION, SODIUM ION, ... | | Authors: | De Colibus, L, Wang, X, Tijsma, A, Neyts, J, Spyrou, J.A.B, Ren, J, Grimes, J.M, Puerstinger, G, Leyssen, P, Fry, E.E, Rao, Z, Stuart, D.I. | | Deposit date: | 2015-08-06 | | Release date: | 2015-09-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structure Elucidation of Coxsackievirus A16 in Complex with Gpp3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses.
Plos Pathog., 11, 2015
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5A1K
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6F5O
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6F5P
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6XZG
 | | Influenza C virus polymerase in complex with chicken ANP32A - Subclass 3 | | Descriptor: | Influenza viral RNA (vRNA) promoter 47mer, LRRcap domain-containing protein, Polymerase acidic protein, ... | | Authors: | Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E. | | Deposit date: | 2020-02-04 | | Release date: | 2020-11-25 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
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6FLA
 | | 3H5 Fab bound to EDIII of DenV 2 Xtal form 1 | | Descriptor: | CHLORIDE ION, Domain III of Dengue virus 2, GLYCEROL, ... | | Authors: | Flanagan, A, Renner, M, Grimes, J.M. | | Deposit date: | 2018-01-25 | | Release date: | 2018-10-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus.
Nat. Immunol., 19, 2018
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6XZR
 | | Influenza C virus polymerase in complex with chicken ANP32A - Subclass 1 | | Descriptor: | LRRcap domain-containing protein, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E. | | Deposit date: | 2020-02-05 | | Release date: | 2020-11-25 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
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