3O11
 
 | | Anti-beta-amyloid antibody c706 fab in space group c2 | | Descriptor: | C706 HEAVY CHAIN variable region, Ig gamma-1 chain C region chimera, C706 LIGHT CHAIN variable region, ... | | Authors: | Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L. | | Deposit date: | 2010-07-20 | | Release date: | 2010-09-08 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | His-tag binding by antibody C706 mimics beta-amyloid recognition.
J.Mol.Recognit., 24, 2011
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1AJ9
 | | R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S | | Descriptor: | CARBON MONOXIDE, HEMOGLOBIN (ALPHA CHAIN), HEMOGLOBIN (BETA CHAIN), ... | | Authors: | Vasquez, G.B, Ji, X, Fronticelli, C, Gilliland, G.L. | | Deposit date: | 1997-05-16 | | Release date: | 1998-05-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Human carboxyhemoglobin at 2.2 A resolution: structure and solvent comparisons of R-state, R2-state and T-state hemoglobins.
Acta Crystallogr.,Sect.D, 54, 1998
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1HDB
 | | ANALYSIS OF THE CRYSTAL STRUCTURE, MOLECULAR MODELING AND INFRARED SPECTROSCOPY OF THE DISTAL BETA-HEME POCKET VALINE67(E11)-THREONINE MUTATION OF HEMOGLOBIN | | Descriptor: | HEMOGLOBIN (DEOXY) BETA-V67T, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | Authors: | Pechik, I, Ji, X, Fronticelli, C, Gilliland, G.L. | | Deposit date: | 1995-04-14 | | Release date: | 1996-04-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin.
Biochemistry, 35, 1996
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5TLK
 | | COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, H2191 HEAVY CHAIN, ... | | Authors: | Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L. | | Deposit date: | 2016-10-11 | | Release date: | 2017-02-08 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol. Immunol., 83, 2017
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31BI
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5W06
 | | HUMAN TISSUE FACTOR IN COMPLEX WITH ANTIBODY M1587 | | Descriptor: | GLYCEROL, M1587 FAB HEAVY CHAIN, M1587 FAB LIGHT CHAIN, ... | | Authors: | Teplyakov, A, Obmolova, G, Malia, T.J, Gilliland, G.L. | | Deposit date: | 2017-05-30 | | Release date: | 2017-06-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural insights into humanization of anti-tissue factor antibody 10H10.
MAbs, 10, 2018
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5TL5
 | | COMPLEX BETWEEN HUMAN CD27 AND ANTIBODY M2177 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, M2177 HEAVY CHAIN, ... | | Authors: | Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L. | | Deposit date: | 2016-10-10 | | Release date: | 2017-06-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of CD27 in complex with a neutralizing noncompeting antibody.
Acta Crystallogr F Struct Biol Commun, 73, 2017
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5VME
 | | Crystal structure of human IgG1 Fc K248E, T437R mutant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, human IgG1 Fc K248E,T437R mutant | | Authors: | Armstrong, A.A, Gilliland, G.L. | | Deposit date: | 2017-04-27 | | Release date: | 2017-08-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.
MAbs, 9, 2017
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5UBX
 | | Crystal structure of a mutant mIgG2b Fc heterodimer in complex with Protein A peptide analog Z34C | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-2B chain C region, ... | | Authors: | Armstrong, A.A, Zwolak, A, Gilliland, G.L. | | Deposit date: | 2016-12-21 | | Release date: | 2017-09-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.
MAbs, 9, 2017
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5TLJ
 | | COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, M2177 HEAVY CHAIN, ... | | Authors: | Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L. | | Deposit date: | 2016-10-11 | | Release date: | 2017-02-08 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol. Immunol., 83, 2017
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5W3P
 | | ANTIBODY C706 IN COMPLEX WTH BETA-AMYLOID PEPTIDE 1-16 | | Descriptor: | Amyloid beta A4 protein, Antibody C706 Fab HEAVY CHAIN, Antibody C706 Fab LIGHT CHAIN, ... | | Authors: | Teplyakov, A, Obmolova, G, Gilliland, G.L. | | Deposit date: | 2017-06-08 | | Release date: | 2017-09-20 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | A coiled conformation of amyloid-beta recognized by antibody C706.
Alzheimers Res Ther, 9, 2017
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5W05
 | | ANTI-TISSUE FACTOR ANTIBODY M59, A HUMANIZED VERSION OF 10H10 | | Descriptor: | DI(HYDROXYETHYL)ETHER, M59 FAB HEAVY CHAIN, M59 FAB LIGHT CHAIN | | Authors: | Teplyakov, A, Obmolova, G, Malia, T.J, Gilliland, G.L. | | Deposit date: | 2017-05-30 | | Release date: | 2017-06-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Structural insights into humanization of anti-tissue factor antibody 10H10.
MAbs, 10, 2018
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5W5L
 | | Crystal structure of human IgG1-Sigma Fc fragment | | Descriptor: | Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Armstrong, A.A, Gilliland, G.L. | | Deposit date: | 2017-06-15 | | Release date: | 2017-09-13 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.
Antibodies, 6, 2017
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5W5N
 | | Crystal structure of human IgG4-Sigma2 Fc fragment | | Descriptor: | ACETATE ION, GLYCEROL, Immunoglobulin heavy constant gamma 4, ... | | Authors: | Armstrong, A.A, Gilliland, G.L. | | Deposit date: | 2017-06-15 | | Release date: | 2017-09-13 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.
Antibodies, 6, 2017
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5W5M
 | | Crystal structure of human IgG4-Sigma1 Fc fragment | | Descriptor: | ACETATE ION, GLYCEROL, Immunoglobulin heavy constant gamma 4, ... | | Authors: | Armstrong, A.A, Gilliland, G.L. | | Deposit date: | 2017-06-15 | | Release date: | 2017-09-13 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.
Antibodies, 6, 2017
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5WK3
 | | CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB | | Descriptor: | C-C motif chemokine 17, GLYCEROL, M116 HEAVY CHAIN, ... | | Authors: | Teplyakov, A, Obmolova, G, Gilliland, G.L. | | Deposit date: | 2017-07-24 | | Release date: | 2017-12-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural insights into chemokine CCL17 recognition by antibody M116.
Biochem Biophys Rep, 13, 2018
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1IN0
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1J9A
 | | OLIGORIBONUCLEASE | | Descriptor: | OLIGORIBONUCLEASE, SULFATE ION | | Authors: | Bonander, N, Tordova, M, Ladner, J.E, Eisenstein, E, Gilliland, G.L, Structure 2 Function Project (S2F) | | Deposit date: | 2001-05-24 | | Release date: | 2003-06-24 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Crystal Structure of Haemophilus Influenzae HI1715, an Oligoribonuclease
To be Published
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1JOP
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1JOS
 | | Ribosome Binding Factor A(rbfA) | | Descriptor: | RIBOSOME-BINDING FACTOR A | | Authors: | Bonander, N, Tordova, M, Howard, A.J, Eisenstein, E, Gilliland, G.L, Structure 2 Function Project (S2F) | | Deposit date: | 2001-07-30 | | Release date: | 2003-06-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The 1.7-A Crystal Structure of HI1288 - Ribosome Binding Factor A (rbfA), a Cold Response Protein
To be Published
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1JAL
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1JJV
 | | DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DEPHOSPHO-COA KINASE, MERCURY (II) ION, ... | | Authors: | Obmolova, G, Teplyakov, A, Bonander, N, Eisenstein, E, Howard, A.J, Gilliland, G.L, Structure 2 Function Project (S2F) | | Deposit date: | 2001-07-09 | | Release date: | 2002-05-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae.
J.Struct.Biol., 136, 2001
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1LQA
 | | TAS PROTEIN FROM ESCHERICHIA COLI IN COMPLEX WITH NADPH | | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Tas protein | | Authors: | Obmolova, G, Teplyakov, A, Khil, P.P, Howard, A.J, Camerini-Otero, R.D, Gilliland, G.L, Structure 2 Function Project (S2F) | | Deposit date: | 2002-05-09 | | Release date: | 2003-07-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.604 Å) | | Cite: | Crystal structure of the Escherichia coli Tas protein, an NADP(H)-dependent aldo-keto reductase
PROTEINS: STRUCT.,FUNCT.,GENET., 53, 2003
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1M65
 | | YCDX PROTEIN | | Descriptor: | Hypothetical protein ycdX, SODIUM ION, SULFATE ION, ... | | Authors: | Teplyakov, A, Obmolova, G, Khil, P.P, Camerini-Otero, R.D, Gilliland, G.L, Structure 2 Function Project (S2F) | | Deposit date: | 2002-07-12 | | Release date: | 2003-04-22 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Crystal structure of the Escherichia coli YcdX protein reveals a trinuclear zinc active site
PROTEINS: STRUCT.,FUNCT.,GENET., 51, 2003
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1SUB
 | | CALCIUM-INDEPENDENT SUBTILISIN BY DESIGN | | Descriptor: | ACETONE, CALCIUM ION, POTASSIUM ION, ... | | Authors: | Gallagher, T, Bryan, P, Gilliland, G.L. | | Deposit date: | 1992-06-10 | | Release date: | 1994-01-31 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Calcium-independent subtilisin by design.
Proteins, 16, 1993
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