225D
 
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8SMO
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8CT8
 | | Crystal structure of Drosophila melanogaster PRL/CBS-pair domain complex | | Descriptor: | IODIDE ION, PRL-1 phosphatase, Unextended protein | | Authors: | Fakih, R, Goldstein, R.H, Kozlov, G, Gehring, K. | | Deposit date: | 2022-05-13 | | Release date: | 2023-03-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver.
J.Biol.Chem., 299, 2023
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7US1
 | | Structure of parkin (R0RB) bound to two phospho-ubiquitin molecules | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase parkin, ... | | Authors: | Fakih, R, Sauve, V, Gehring, K. | | Deposit date: | 2022-04-22 | | Release date: | 2022-06-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.484 Å) | | Cite: | Structure of the second phosphoubiquitin-binding site in parkin.
J.Biol.Chem., 298, 2022
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8W31
 | | Crystal structure of parkin (R0RB):2pUb with activator compound | | Descriptor: | (S)-1-(6-benzyl-3-(4-(1,2,3,4-tetrahydroquinoline-1-carbonyl)phenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)ethan-1-one, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... | | Authors: | Sauve, V, Gehring, K. | | Deposit date: | 2024-02-21 | | Release date: | 2024-08-21 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Activation of parkin by a molecular glue.
Nat Commun, 15, 2024
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6WUR
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5WD8
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1HO6
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1HOQ
 | | CHIMERIC RNA/DNA HAIRPIN | | Descriptor: | DNA/RNA (5'-R(*GP*GP*AP*C)-D(P*TP*TP*CP*GP*GP*TP*CP*C)-3') | | Authors: | Denisov, A.Y, Gehring, K. | | Deposit date: | 2000-12-11 | | Release date: | 2001-11-07 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'-fluoro-ANA/RNA and DNA/RNA hybrids.
Nucleic Acids Res., 29, 2001
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5WD9
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3BCY
 | | Crystal structure of YER067W | | Descriptor: | Protein YER067W | | Authors: | Kozlov, G, Gehring, K. | | Deposit date: | 2007-11-13 | | Release date: | 2008-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance.
Plos One, 5, 2010
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3BXY
 | | Crystal structure of tetrahydrodipicolinate N-succinyltransferase from E. coli | | Descriptor: | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | | Authors: | Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | | Deposit date: | 2008-01-15 | | Release date: | 2008-01-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of Escherichia coli tetrahydrodipicolinate N-succinyltransferase reveals the role of a conserved C-terminal helix in cooperative substrate binding.
Febs Lett., 582, 2008
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4NWY
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3UVT
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8GK6
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7M1T
 | | Crystal structure of an archaeal CNNM, MtCorB, with C-terminal deletion in complex with Mg2+-ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Hemolysin, contains CBS domains, ... | | Authors: | Chen, Y.S, Kozlov, G, Gehring, K. | | Deposit date: | 2021-03-15 | | Release date: | 2021-06-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.26 Å) | | Cite: | Crystal structure of an archaeal CorB magnesium transporter.
Nat Commun, 12, 2021
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6PIH
 | | Hexameric ArnA cryo-EM structure | | Descriptor: | Bifunctional polymyxin resistance protein ArnA, UDP-4-amino-4-deoxy-L-arabinose formyltransferase | | Authors: | Yang, M, Gehring, K. | | Deposit date: | 2019-06-26 | | Release date: | 2019-07-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements.
J.Struct.Biol., 208, 2019
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8G91
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8G90
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6PIK
 | | Tetrameric cryo-EM ArnA | | Descriptor: | Bifunctional polymyxin resistance protein ArnA, UDP-4-amino-4-deoxy-L-arabinose formyltransferase | | Authors: | Yang, M, Gehring, K. | | Deposit date: | 2019-06-26 | | Release date: | 2019-07-31 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements.
J.Struct.Biol., 208, 2019
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7MSU
 | | Crystal structure of an archaeal CNNM, MtCorB, CBS-pair domain in complex with Mg2+-ATP | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Hemolysin, ... | | Authors: | Chen, Y.S, Gehring, K. | | Deposit date: | 2021-05-12 | | Release date: | 2021-06-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Crystal structure of an archaeal CorB magnesium transporter.
Nat Commun, 12, 2021
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7M1U
 | | Crystal structure of an archaeal CNNM, MtCorB, R235L mutant with C-terminal deletion | | Descriptor: | Hemolysin, contains CBS domains | | Authors: | Chen, Y.S, Kozlov, G, Gehring, K. | | Deposit date: | 2021-03-15 | | Release date: | 2021-06-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Crystal structure of an archaeal CorB magnesium transporter.
Nat Commun, 12, 2021
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8EY8
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8EY6
 | | LaM domain of human LARP1 in complex with AAAAAG RNA | | Descriptor: | Isoform 2 of La-related protein 1, RNA (5'-R(*AP*AP*AP*AP*AP*G)-3'), SULFATE ION | | Authors: | Kozlov, G, Gehring, K. | | Deposit date: | 2022-10-26 | | Release date: | 2023-11-01 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1.
Rna Biol., 21, 2024
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8EY7
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