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PDB: 161 件

6NRP
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Putative short-chain dehydrogenase/reductase (SDR) from Acinetobacter baumannii
分子名称: 3-oxoacyl-ACP reductase FabG
著者Cross, E.M, Smith, K.M, Shaw, K.I, Aragao, D, Forwood, J.K.
登録日2019-01-23
公開日2019-02-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Insights into Acinetobacter baumannii fatty acid synthesis 3-oxoacyl-ACP reductases.
Sci Rep, 11, 2021
4NCP
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Crystal Structure of 4-HBT like thioesterase SAV1878 from Staphylococcus aureus subsp. aureus Mu50
分子名称: Uncharacterized protein
著者Khandokar, Y.B, Forwood, J.K.
登録日2013-10-24
公開日2014-11-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Expression, purification, crystallization, and X-ray diffraction analysis of hypothetical protein SAV1878 from Staphylococcus aureus subsp. aureus Mu50
To be Published
7JJM
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Crystal structure of Importin alpha 2 in complex with LSD1 NLS
分子名称: CHLORIDE ION, Importin subunit alpha-1, Lysine-specific histone demethylase 1A
著者Tu, W.J, McGuaig, R, Tan, H.Y.A, Hardy, C, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
6VZ6
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Methanococcoides burtonii cytochrome b5 domain protein (WP 011499504.1)
分子名称: Cytochrome b5-domain protein, PROTOPORPHYRIN IX CONTAINING FE
著者Teakel, S.L, Forwood, J.K, Aragao, D, Cahill, M.A, Marama, M.
登録日2020-02-27
公開日2020-03-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Methanococcoides burtonii cytochrome b5 domain protein (WP 011499504.1)
To Be Published
5HHG
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Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex
分子名称: Importin subunit alpha-1, RNA-directed RNA polymerase NS5
著者Smith, K.M, Forwood, J.K.
登録日2016-01-11
公開日2016-05-18
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.
PLoS Pathog., 12, 2016
8ECH
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Tick-borne encephalitis virus capsid protein NLS bound to host importin alpha 2
分子名称: Capsid protein C, Importin subunit alpha-1
著者Roby, J.A, Forwood, J.K.
登録日2022-09-02
公開日2022-09-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure and biological functions of tick-borne encephalitis virus capsid protein
To Be Published
5HZ4
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The structural and biochemical characterization of acyl-coa hydrolase mutant Thr60Ala from Staphylococcus aureus.
分子名称: Thioesterase
著者Khandokar, Y.B, Srivastava, P, Forwood, J.K.
登録日2016-02-02
公開日2016-04-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The structural and biochemical characterization of acyl-coa hydrolase mutant Thr60Ala from Staphylococcus aureus.
To Be Published
6VFM
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Crystal structure of SpeG allosteric polyamine acetyltransferase from Bacillus thuringiensis
分子名称: Spermidine N1-acetyltransferase
著者Tsimbalyuk, S, Shornikov, A, Le, V.T.B, Kuhn, M.L, Forwood, J.K.
登録日2020-01-05
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献SpeG polyamine acetyltransferase enzyme from Bacillus thuringiensis forms a dodecameric structure and exhibits high catalytic efficiency.
J.Struct.Biol., 210, 2020
8G4J
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Crystal structure of Cavia porcellus (guinea pig) importin-alpha 1 in cargo-free state
分子名称: Importin subunit alpha
著者Hawker, J.E, Roby, J.A, Stewart, M, Forwood, J.K.
登録日2023-02-09
公開日2023-02-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of Cavia porcellus (guinea pig) importin-alpha 1 in cargo-free state
To Be Published
4OIH
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Importin Alpha in Complex with the Bipartite NLS of Prp20
分子名称: Guanine nucleotide exchange factor SRM1, Importin subunit alpha-1
著者Roman, N, Christie, M, Swarbrick, C.M.D, Kobe, B, Forwood, J.K.
登録日2014-01-19
公開日2014-02-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
Plos One, 8, 2013
6UUV
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Crystal structure of a high molecular weight 3-oxoacyl-ACP reductase (FabG) from Acinetobacter baumannii crystal form 1
分子名称: 3-ketoacyl-ACP reductase
著者Cross, E.M, Forwood, J.K.
登録日2019-11-01
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Insights into Acinetobacter baumannii fatty acid synthesis 3-oxoacyl-ACP reductases.
Sci Rep, 11, 2021
6UUT
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Crystal structure of a high molecular weight 3-oxoacyl-ACP reductase (FabG) from Acinetobacter baumannii crystal form 2
分子名称: 3-ketoacyl-ACP reductase
著者Cross, E.M, Forwood, J.K.
登録日2019-10-31
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Insights into Acinetobacter baumannii fatty acid synthesis 3-oxoacyl-ACP reductases.
Sci Rep, 11, 2021
8F2Q
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Human Parvovirus B19 Nonstructural NS1 Protein NLS bound to Importin Alpha 2
分子名称: Importin subunit alpha-1, Initiator protein NS1
著者Cross, E.M, Forwood, J.K.
登録日2022-11-08
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Importin alpha / beta-dependent nuclear transport of human parvovirus B19 nonstructural protein 1 is essential for viral replication.
Antiviral Res., 213, 2023
4QFW
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Crystal structure of acyl-CoA thioesterase tesB from Yersinia pestis
分子名称: Acyl-CoA thioesterase II
著者Swarbrick, C.M.D, Forwood, J.K.
登録日2014-05-21
公開日2014-06-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystallization of the acyl-CoA thioesterase TesB from Yersinia pestis.
Acta Crystallogr.,Sect.F, 69, 2013
6NQM
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Crystal structure of Human LSD1
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A
著者Tan, A.H.Y, Tu, W, McCuaig, R, Donovan, T, Tsimbalyuk, S, Forwood, J.K, Rao, S.
登録日2019-01-21
公開日2019-02-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Front Immunol, 10, 2019
7RG6
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Importin alpha2 in complex with ORF4B Bat coronavirus HKU5
分子名称: Importin subunit alpha-1, Non-structural protein ORF4b
著者Foster, J.K, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K.
登録日2021-07-14
公開日2021-08-25
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Nat Commun, 13, 2022
6NR5
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Human LSD1 in complex with Phenelzine sulfate
分子名称: Lysine-specific histone demethylase 1A, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3R,4R)-5-[(4aR)-7,8-dimethyl-2,4-dioxo-5-(2-phenylethyl)-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name)
著者Tan, A.H.Y, Tu, W, McCuaig, R, Donovan, T, Tsimbalyuk, S, Forwood, J.K, Rao, S.
登録日2019-01-22
公開日2019-07-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Front Immunol, 10, 2019
6NQU
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Human LSD1 in complex with GSK2879552
分子名称: Lysine-specific histone demethylase 1A, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{S})-5-[(9~{S},11~{R})-15,16-dimethyl-11-oxidanyl-5,7-bis(oxidanylidene)-9-phenyl-2,4,6,12-tetrazabicyclo[11.4.0]heptadeca-1(17),13,15-trien-2-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate
著者Tan, A.H.Y, Tu, W, McCuaig, R, Donovan, T, Tsimbalyuk, S, Forwood, J.K, Rao, S.
登録日2019-01-21
公開日2019-02-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Front Immunol, 10, 2019
6NZX
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Hadesarchaea YNP_N21 cytochrome b5 domain protein (KUO41884.1)
分子名称: Cytochrome B5, PROTOPORPHYRIN IX CONTAINING FE
著者Teakel, S.L, Marama, M.S, Aragao, D, Forwood, J.K, Cahill, M.A.
登録日2019-02-14
公開日2019-03-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Hadesarchaea YNP_N21 cytochrome b5 domain protein (KUO41884.1)
To Be Published
4ZRB
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Crystal Structure of Hypothetical Thioesterase Protein SP_1851 with Coenzyme A from Streptococcus pneumoniae TIGR4
分子名称: COENZYME A, Hypothetical Thioesterase Protein SP_1851
著者Khandokar, Y.B, Srivastava, P, Forwood, J.K.
登録日2015-05-12
公開日2015-05-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and Functional Characterization of the PaaI Thioesterase from Streptococcus pneumoniae Reveals a Dual Specificity for Phenylacetyl-CoA and Medium-chain Fatty Acyl-CoAs and a Novel CoA-induced Fit Mechanism.
J.Biol.Chem., 291, 2016
7JJL
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Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS
分子名称: Importin subunit alpha-3, Lysine-specific histone demethylase 1A
著者Tu, W.J, McCuaig, R, Tan, H.Y.A, Hardy, K, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JK7
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Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant
分子名称: GLYCEROL, Importin subunit alpha-1, Lysine-specific histone demethylase 1A
著者Tu, W.J, McCuaig, R, Tan, A.H.Y, Hardy, K, Seddiki, N, Ali, S, Dahlstron, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
8FK3
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Adeno-Associated Virus Porcine Origin capsid protein basic regions in complex with Importin-alpha 2
分子名称: Importin subunit alpha-1, VP1
著者Hoad, M, Forwood, J.K, Roby, J.A.
登録日2022-12-20
公開日2023-03-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal.
Viruses, 15, 2023
6BVZ
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Importin alpha 3 in cargo free state
分子名称: Importin subunit alpha-3
著者Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
登録日2017-12-14
公開日2018-07-04
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
6BW9
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Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 1
分子名称: Importin subunit alpha-3, Protein W
著者Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K.
登録日2017-12-14
公開日2018-07-04
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018

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