7RWF
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![BU of 7rwf by Molmil](/molmil-images/mine/7rwf) | Crystal structure of CDK2 in complex with TW8672 | Descriptor: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, Cyclin-dependent kinase 2 | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-08-19 | Release date: | 2022-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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7NCX
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![BU of 7ncx by Molmil](/molmil-images/mine/7ncx) | Crystal structure of GH30 (double mutant EE) from Thermothelomyces thermophila. | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | Authors: | Dimarogona, M, Nikolaivits, E, Topakas, E, Weiss, M, Feiler, C.G. | Deposit date: | 2021-01-29 | Release date: | 2021-09-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies Carbohydrate Polymers, 273, 2021
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4U5L
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![BU of 4u5l by Molmil](/molmil-images/mine/4u5l) | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | Descriptor: | Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-L-lysinamide | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | Deposit date: | 2014-07-25 | Release date: | 2015-05-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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4U5V
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![BU of 4u5v by Molmil](/molmil-images/mine/4u5v) | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | Descriptor: | Importin subunit alpha-1, N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | Deposit date: | 2014-07-25 | Release date: | 2015-05-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.968 Å) | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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5LJO
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![BU of 5ljo by Molmil](/molmil-images/mine/5ljo) | E. coli BAM complex (BamABCDE) by cryoEM | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Iadanza, M.G, Ranson, N.A, Radford, S.E, Higgins, A.J, Schffrin, B, Calabrese, A.N, Ashcroft, A.E, Brockwell, D.J. | Deposit date: | 2016-07-19 | Release date: | 2016-10-12 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Lateral opening in the intact beta-barrel assembly machinery captured by cryo-EM. Nat Commun, 7, 2016
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4U9C
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![BU of 4u9c by Molmil](/molmil-images/mine/4u9c) | |
4TWY
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![BU of 4twy by Molmil](/molmil-images/mine/4twy) | Structure of SARS-3CL protease complex with a phenylbenzoyl (S,R)-N-decalin type inhibitor | Descriptor: | (2S)-2-({[(3S,4aR,8aS)-2-(biphenyl-4-ylcarbonyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal, 3C-like proteinase | Authors: | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | Deposit date: | 2014-07-02 | Release date: | 2015-02-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors Bioorg.Med.Chem., 23, 2015
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4U1Z
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![BU of 4u1z by Molmil](/molmil-images/mine/4u1z) | GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form D | Descriptor: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9401 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U22
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![BU of 4u22 by Molmil](/molmil-images/mine/4u22) | GluA2flip sLBD complexed with FW and (R,R)-2b crystal form D | Descriptor: | 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4409 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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4U23
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![BU of 4u23 by Molmil](/molmil-images/mine/4u23) | GluA2flip sLBD complexed with FW and (R,R)-2b crystal form F | Descriptor: | 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | Authors: | Chen, L, Gouaux, E. | Deposit date: | 2014-07-16 | Release date: | 2014-08-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6734 Å) | Cite: | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
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7NJW
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![BU of 7njw by Molmil](/molmil-images/mine/7njw) | Mycobacterium smegmatis ATP synthase Fo combined class 3 | Descriptor: | ATP synthase subunit a, ATP synthase subunit b, ATP synthase subunit b-delta, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-17 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NJV
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![BU of 7njv by Molmil](/molmil-images/mine/7njv) | Mycobacterium smegmatis ATP synthase Fo combined class 2 | Descriptor: | ATP synthase subunit a, ATP synthase subunit b, ATP synthase subunit b-delta, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-17 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NKN
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![BU of 7nkn by Molmil](/molmil-images/mine/7nkn) | Mycobacterium smegmatis ATP synthase rotor state 3 | Descriptor: | ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit alpha, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-18 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NJU
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![BU of 7nju by Molmil](/molmil-images/mine/7nju) | Mycobacterium smegmatis ATP synthase Fo combined class 1 | Descriptor: | ATP synthase subunit a, ATP synthase subunit b, ATP synthase subunit b-delta, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-17 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NJY
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![BU of 7njy by Molmil](/molmil-images/mine/7njy) | Mycobacterium smegmatis ATP synthase Fo combined class 5 | Descriptor: | ATP synthase subunit a, ATP synthase subunit b, ATP synthase subunit b-delta, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-17 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NKK
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![BU of 7nkk by Molmil](/molmil-images/mine/7nkk) | Mycobacterium smegmatis ATP synthase rotor state 2 | Descriptor: | ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit alpha, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-18 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NL9
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![BU of 7nl9 by Molmil](/molmil-images/mine/7nl9) | Mycobacterium smegmatis ATP synthase Fo state 3 | Descriptor: | ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit a, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-22 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S84
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![BU of 7s84 by Molmil](/molmil-images/mine/7s84) | Crystal structure of CDK2 liganded with compound TW8972 | Descriptor: | 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2 | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-09-17 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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7NJT
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![BU of 7njt by Molmil](/molmil-images/mine/7njt) | Mycobacterium smegmatis ATP synthase Fo combined all classes | Descriptor: | ATP synthase subunit a, ATP synthase subunit b, ATP synthase subunit b-delta, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-17 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NJX
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![BU of 7njx by Molmil](/molmil-images/mine/7njx) | Mycobacterium smegmatis ATP synthase Fo combined class 4 | Descriptor: | ATP synthase subunit a, ATP synthase subunit b, ATP synthase subunit b-delta, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-17 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.32 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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7NKB
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![BU of 7nkb by Molmil](/molmil-images/mine/7nkb) | Mycobacterium smegmatis ATP synthase rotor state 1 | Descriptor: | ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit alpha, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-17 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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4XA9
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![BU of 4xa9 by Molmil](/molmil-images/mine/4xa9) | Crystal structure of the complex between the N-terminal domain of RavJ and LegL1 from Legionella pneumophila str. Philadelphia | Descriptor: | Gala protein type 1, 3 or 4, Uncharacterized protein | Authors: | Stogios, P.J, Cuff, M.E, Nocek, B, Evdokimova, E, Di Leo, R, Yim, V, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-12-13 | Release date: | 2015-01-28 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila. Mol. Syst. Biol., 12, 2016
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7NKP
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![BU of 7nkp by Molmil](/molmil-images/mine/7nkp) | Mycobacterium smegmatis ATP synthase Fo state 2 | Descriptor: | ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit a, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-18 | Release date: | 2021-10-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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6XNK
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![BU of 6xnk by Molmil](/molmil-images/mine/6xnk) | |
7NK9
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![BU of 7nk9 by Molmil](/molmil-images/mine/7nk9) | Mycobacterium smegmatis ATP synthase Fo domain state 1 | Descriptor: | ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit a, ... | Authors: | Montgomery, M.G, Petri, J, Spikes, T.E, Walker, J.E. | Deposit date: | 2021-02-17 | Release date: | 2021-11-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of the ATP synthase from Mycobacterium smegmatis provides targets for treating tuberculosis. Proc.Natl.Acad.Sci.USA, 118, 2021
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