5D87
 
 | | Staphyloferrin B precursor biosynthetic enzyme SbnA Y152F/S185G variant | | 分子名称: | MAGNESIUM ION, POTASSIUM ION, PYRIDOXAL-5'-PHOSPHATE, ... | | 著者 | Kobylarz, M.J, Grigg, J.C, Liu, Y, Lee, M.S.F, Heinrichs, D.E, Murphy, M.E.P. | | 登録日 | 2015-08-15 | | 公開日 | 2016-02-03 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis.
Biochemistry, 55, 2016
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6C53
 | | Cryo-EM structure of the Type 1 pilus rod | | 分子名称: | Type-1 fimbrial protein, A chain | | 著者 | Zheng, W, Wang, F, Luna-Rico, A, Francetic, O, Hultgren, S.J, Egelman, E.H. | | 登録日 | 2018-01-13 | | 公開日 | 2018-01-31 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.
Elife, 7, 2018
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3MVV
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS F34A at cryogenic temperature | | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | 著者 | Caro, J.A, Schlessman, J.L, Garcia-Moreno, E.B, Heroux, A. | | 登録日 | 2010-05-04 | | 公開日 | 2011-03-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Cavities determine the pressure unfolding of proteins.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4G4E
 | | Crystal structure of the L88A mutant of HslV from Escherichia coli | | 分子名称: | ATP-dependent protease subunit HslV | | 著者 | Lee, J.W, Park, E, Yoo, H.M, Ha, B.H, An, J.Y, Jeon, Y.J, Seol, J.H, Eom, S.H, Chung, C.H. | | 登録日 | 2012-07-16 | | 公開日 | 2013-06-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.888 Å) | | 主引用文献 | Structural Alteration in the Pore Motif of the Bacterial 20S Proteasome Homolog HslV Leads to Uncontrolled Protein Degradation
J.Mol.Biol., 425, 2013
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1D7A
 | | CRYSTAL STRUCTURE OF E. COLI PURE-MONONUCLEOTIDE COMPLEX. | | 分子名称: | 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE | | 著者 | Mathews, I.I, Kappock, T.J, Stubbe, J, Ealick, S.E. | | 登録日 | 1999-10-16 | | 公開日 | 1999-12-03 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure Fold.Des., 7, 1999
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5KRL
 | | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the A-CD ring estrogen, (1S,7aS)-5-(2-chloro-4-hydroxyphenyl)-7a-methyl-2,3,3a,4,7,7a-hexahydro-1H-inden-1-ol | | 分子名称: | (1~{S},3~{a}~{R},7~{a}~{S})-5-(2-chloranyl-4-oxidanyl-phenyl)-2,3,3~{a},4,7,7~{a}-hexahydro-1~{H}-inden-1-ol, Estrogen receptor, NCOA2 | | 著者 | Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. | | 登録日 | 2016-07-07 | | 公開日 | 2017-01-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
Cell Chem Biol, 24, 2017
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4Z82
 | | Cysteine bound rat cysteine dioxygenase C164S variant at pH 8.1 | | 分子名称: | CYSTEINE, Cysteine dioxygenase type 1, FE (II) ION | | 著者 | Fellner, M, Tchesnokov, E.P, Siakkou, E, Rutledge, M.T, Kanitz, M, Jameson, G.N.L, Wilbanks, S.M. | | 登録日 | 2015-04-08 | | 公開日 | 2016-06-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Influence of cysteine 164 on active site structure in rat cysteine dioxygenase.
J.Biol.Inorg.Chem., 21, 2016
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5KUT
 | | hMiro2 C-terminal GTPase domain, GDP-bound | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitochondrial Rho GTPase 2 | | 著者 | Klosowiak, J.L, Focia, P.J, Rice, S.E, Freymann, D.M. | | 登録日 | 2016-07-13 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.693 Å) | | 主引用文献 | Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Sci Rep, 6, 2016
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4G8J
 | | X-ray Structure of Uridine Phosphorylease from Vibrio cholerae Complexed with Thymidine at 2.12 A Resolution | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Lashkov, A.A, Gabdoulkhakov, A.G, Prokofev, I.I, Sotnichenko, S.E, Betzel, C, Mikhailov, A.M. | | 登録日 | 2012-07-23 | | 公開日 | 2013-07-24 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.119 Å) | | 主引用文献 | X-ray structure of uridine phosphorylease from Vibrio cholerae complexed with thymidine
To be Published
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7BZJ
 | | The Discovery of Benzhydrol-Oxaborole Hybrid Derivatives as Leucyl-tRNA Synthetase Inhibitors | | 分子名称: | Leucine--tRNA ligase, [(1~{R},5~{R},6~{S},8~{R})-8-(6-aminopurin-9-yl)-4'-[(~{R})-oxidanyl-[4-(2-oxidanylidenepropylsulfanyl)phenyl]methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,7'-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-6-yl]methoxy-tris(oxidanyl)phosphanium | | 著者 | Liu, R.J, Li, H, Wang, E.D, Zhou, H. | | 登録日 | 2020-04-28 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors.
Bioorg.Med.Chem., 29, 2021
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4SKN
 | | A NUCLEOTIDE-FLIPPING MECHANISM FROM THE STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO DNA | | 分子名称: | DNA (5'-D(*AP*AP*AP*GP*CP*CP*GP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*(D1P)P*GP*GP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE), ... | | 著者 | Slupphaug, G, Mol, C.D, Kavli, B, Arvai, A.S, Krokan, H.E, Tainer, J.A. | | 登録日 | 1999-02-20 | | 公開日 | 1999-02-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature, 384, 1996
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6WVR
 | | Tubulin dimers from a 13-protofilament, Taxol stabilized microtubule | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Debs, G.E, Cha, M, Huehn, A.R, Sindelar, C.V. | | 登録日 | 2020-05-06 | | 公開日 | 2020-05-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Dynamic and asymmetric fluctuations in the microtubule wall captured by high-resolution cryoelectron microscopy.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5V3D
 | | Crystal structure of fosfomycin resistance protein from Klebsiella pneumoniae with bound fosfomycin | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, FOSFOMYCIN, ... | | 著者 | Klontz, E, Guenther, S, Silverstein, Z, Sundberg, E. | | 登録日 | 2017-03-07 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.539 Å) | | 主引用文献 | Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli.
Antimicrob. Agents Chemother., 61, 2017
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2W0K
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4TKF
 | | Crystal Structure of human Tankyrase 2 in complex with IWR-1. | | 分子名称: | 3-aminobenzamide, 4-[(3aR,4R,7S,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide, Tankyrase-2, ... | | 著者 | Qiu, W, Lam, R, Romanov, V, Gordon, R, Gebremeskel, S, Vodsedalek, J, Thompson, C, Beletskaya, I, Battaile, K.P, Pai, E.F, Chirgadze, N.Y. | | 登録日 | 2014-05-26 | | 公開日 | 2014-11-05 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr.,Sect.D, 70, 2014
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6NEU
 | | FAD-dependent monooxygenase TropB from T. stipitatus R206Q variant | | 分子名称: | CHLORIDE ION, FAD-dependent monooxygenase tropB, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Rodriguez Benitez, A, Tweedy, S.E, Baker Dockrey, S.A, Lukowski, A.L, Wymore, T, Khare, D, Brooks, C.L, Palfey, B.A, Smith, J.L, Narayan, A.R.H. | | 登録日 | 2018-12-18 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for selectivity in flavin-dependent monooxygenase-catalyzed oxidative dearomatization.
Acs Catalysis, 9, 2019
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5KNM
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5KO0
 | | Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED | | 分子名称: | THIOCYANATE ION, hIAPP(15-25)WT | | 著者 | Krotee, P.A.L, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Shi, D, Nannenga, B.L, Hattne, J, Reyes, F.E, Gonen, T, Eisenberg, D.S. | | 登録日 | 2016-06-28 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.4 Å) | | 主引用文献 | Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity.
Elife, 6, 2017
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3J47
 | | Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid | | 分子名称: | 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit RPN3, ... | | 著者 | Estrin, E, Lopez-Blanco, J.R, Chacon, P, Martin, A. | | 登録日 | 2013-06-27 | | 公開日 | 2013-08-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Formation of an Intricate Helical Bundle Dictates the Assembly of the 26S Proteasome Lid.
Structure, 21, 2013
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3MWF
 | | Crystal structure of Staphylococcus aureus SirA complexed with staphyloferrin B | | 分子名称: | 5-[(2-{[(3S)-5-{[(2S)-2-amino-2-carboxyethyl]amino}-3-carboxy-3-hydroxy-5-oxopentanoyl]amino}ethyl)amino]-2,5-dioxopentanoic acid, FE (III) ION, Iron-regulated ABC transporter siderophore-binding protein SirA | | 著者 | Grigg, J.C, Murphy, M.E.P. | | 登録日 | 2010-05-05 | | 公開日 | 2010-09-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Staphylococcus aureus SirA specificity for staphyloferrin B is driven by localized conformational change
To be Published
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5KRS
 | | HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid | | 分子名称: | 3-pyrrol-1-ylthiophene-2-carboxylic acid, DIMETHYL SULFOXIDE, Integrase | | 著者 | Patel, D, Bauman, J.D, Arnold, E. | | 登録日 | 2016-07-07 | | 公開日 | 2016-09-28 | | 最終更新日 | 2022-03-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
J.Biol.Chem., 291, 2016
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5F7M
 | | Blood group antigen binding adhesin BabA of Helicobacter pylori strain 17875 in complex with blood group H Lewis b hexasaccharide | | 分子名称: | Adhesin binding fucosylated histo-blood group antigen, Nanobody Nb-ER19, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-[alpha-L-fucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Moonens, K, Gideonsson, P, Subedi, S, Romao, E, Oscarson, S, Muyldermans, S, Boren, T, Remaut, H. | | 登録日 | 2015-12-08 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.
Cell Host Microbe, 19, 2016
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6NY3
 | | CasX ternary complex with 30bp target DNA | | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | | 登録日 | 2019-02-10 | | 公開日 | 2019-02-27 | | 最終更新日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
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6WDR
 | | Subunit joining exposes nascent pre-40S rRNA for processing and quality control | | 分子名称: | 20S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S10-A, ... | | 著者 | Rai, J, Parker, M.D, Huang, H, Choy, S, Ghalei, H, Johnson, M.C, Karbstein, K, Stroupe, M.E. | | 登録日 | 2020-04-01 | | 公開日 | 2020-09-30 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
Rna, 27, 2021
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7SJ8
 | | 13pf wildtype microtubule from recombinant human tubulin decorated with kinesin | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | LaFrance, B.J, Greber, B.J, Zhang, R, McCollum, C, Nogales, E. | | 登録日 | 2021-10-16 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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