2R09
| Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... | Authors: | DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G. | Deposit date: | 2007-08-17 | Release date: | 2007-12-04 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors. Mol.Cell, 28, 2007
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2R0D
| Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor | Descriptor: | Cytohesin-3, DI(HYDROXYETHYL)ETHER, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... | Authors: | DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G. | Deposit date: | 2007-08-18 | Release date: | 2007-12-04 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors. Mol.Cell, 28, 2007
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3K3I
| p38alpha bound to novel DGF-out compound PF-00215955 | Descriptor: | (3S)-3-[4-(4-bromophenyl)-1H-imidazol-2-yl]-1,2,3,4-tetrahydroisoquinoline, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14 | Authors: | Kazmirski, S.L, DiNitto, J.P. | Deposit date: | 2009-10-02 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay. Chem.Biol.Drug Des., 74, 2009
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3K3J
| P38alpha bound to novel DFG-out compound PF-00416121 | Descriptor: | 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14 | Authors: | Kazmirski, S.L, DiNitto, J.P. | Deposit date: | 2009-10-02 | Release date: | 2009-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.995 Å) | Cite: | The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay. Chem.Biol.Drug Des., 74, 2009
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1U2B
| Triglycine variant of the Grp1 Pleckstrin Homology Domain unliganded | Descriptor: | Cytohesin 3, SULFATE ION | Authors: | Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G. | Deposit date: | 2004-07-16 | Release date: | 2005-02-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains Embo J., 23, 2004
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1U27
| Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,3,4,5)P4 | Descriptor: | Cytohesin 2, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE | Authors: | Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G. | Deposit date: | 2004-07-16 | Release date: | 2005-02-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains Embo J., 23, 2004
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1U29
| Triglycine variant of the ARNO Pleckstrin Homology Domain in complex with Ins(1,4,5)P3 | Descriptor: | Cytohesin 2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE | Authors: | Cronin, T.C, DiNitto, J.P, Czech, M.P, Lambright, D.G. | Deposit date: | 2004-07-16 | Release date: | 2005-02-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains Embo J., 23, 2004
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