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PDB: 24 件
8BPS
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BU of 8bps by Molmil
Aspartate transcarbamoylase mutant (N2045C, R2238C) from Chaetomium thermophilum CAD-like in apo form
分子名称: Carbamoyl-phosphate synthase (glutamine-hydrolyzing), GLYCEROL
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2022-11-25
公開日2023-02-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD.
Molecules, 28, 2023
8BPL
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BU of 8bpl by Molmil
Aspartate transcarbamoylase mutant (N2045C, R2238C) from Chaetomium thermophilum CAD-like bound to carbamoyl phosphate
分子名称: Carbamoyl-phosphate synthase (glutamine-hydrolyzing), GLYCEROL, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2022-11-16
公開日2023-02-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD.
Molecules, 28, 2023
8PBG
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BU of 8pbg by Molmil
Mutant K1556T of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate
分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBP
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BU of 8pbp by Molmil
Mutant R1785C of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate
分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBE
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BU of 8pbe by Molmil
Mutant K1556T of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate
分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBI
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BU of 8pbi by Molmil
Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate
分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBM
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BU of 8pbm by Molmil
Mutant R1789Q of the dihydroorotase domain of human CAD protein bound to the substrate dihydroorotate
分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBQ
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BU of 8pbq by Molmil
Mutant R1810Q of the dihydroorotase domain of human CAD protein bound to the substrates
分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBR
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BU of 8pbr by Molmil
Mutant R1475Q of the dihydroorotase domain of human CAD protein in apo form
分子名称: CAD protein, FORMIC ACID, ZINC ION
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBJ
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BU of 8pbj by Molmil
Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate
分子名称: CAD protein, FORMIC ACID, GLYCEROL, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBN
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BU of 8pbn by Molmil
Mutant R1789Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate
分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBT
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BU of 8pbt by Molmil
Mutant K1482M of the dihydroorotase domain of human CAD protein bound to the substrate dihydroorotate
分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBU
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BU of 8pbu by Molmil
Mutant K1482M of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate
分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBH
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BU of 8pbh by Molmil
Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate
分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBK
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BU of 8pbk by Molmil
Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate
分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
8PBS
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BU of 8pbs by Molmil
Mutant K1482M of the dihydroorotase domain of human CAD protein in apo form
分子名称: CAD protein, FORMIC ACID, GLYCEROL, ...
著者del Cano-Ochoa, F, Ramon-Maiques, S.
登録日2023-06-09
公開日2023-11-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Beyond genetics: Deciphering the impact of missense variants in CAD deficiency.
J Inherit Metab Dis, 46, 2023
7O4G
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BU of 7o4g by Molmil
Human phosphomannomutase 2 (PMM2) wild-type soaked with the activator glucose 1,6-bisphosphate
分子名称: 1,6-di-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
著者Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V.
登録日2021-04-06
公開日2022-02-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures.
J Inherit Metab Dis, 45, 2022
7O0C
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BU of 7o0c by Molmil
Human phosphomannomutase 2 (PMM2) wild-type in apo state
分子名称: CHLORIDE ION, MAGNESIUM ION, Phosphomannomutase 2, ...
著者Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V.
登録日2021-03-26
公開日2022-02-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures.
J Inherit Metab Dis, 45, 2022
7O1B
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BU of 7o1b by Molmil
Human phosphomannomutase 2 (PMM2) wild-type co-crystallized with the activator glucose 1,6-bisphosphate
分子名称: 1,6-di-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, MAGNESIUM ION, ...
著者Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V.
登録日2021-03-29
公開日2022-02-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures.
J Inherit Metab Dis, 45, 2022
7O5Z
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BU of 7o5z by Molmil
Human phosphomannomutase 2 (PMM2) with mutation T237M in apo state
分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ...
著者Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V.
登録日2021-04-09
公開日2022-02-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures.
J Inherit Metab Dis, 45, 2022
7O58
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BU of 7o58 by Molmil
Human phosphomannomutase 2 (PMM2) with mutation T237M in complex with the activator glucose 1,6-bisphosphate
分子名称: 1,6-di-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
著者Ramon-Maiques, S, Briso-Montiano, A, Del Cano-Ochoa, F, Vilas, A, Perez, B, Rubio, V.
登録日2021-04-08
公開日2022-02-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures.
J Inherit Metab Dis, 45, 2022
6HG2
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BU of 6hg2 by Molmil
Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to fluoroorotate
分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者Ramon-Maiques, S, Del Cano-Ochoa, F.
登録日2018-08-22
公開日2018-10-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.
J. Biol. Chem., 293, 2018
6HG1
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BU of 6hg1 by Molmil
Hybrid dihydroorotase domain of human CAD with E. coli flexible loop in apo state
分子名称: CAD protein,Dihydroorotase,CAD protein, FORMIC ACID, ZINC ION
著者Ramon-Maiques, S, Del Cano-Ochoa, F.
登録日2018-08-22
公開日2018-10-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.
J. Biol. Chem., 293, 2018
6HG3
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BU of 6hg3 by Molmil
Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to dihydroorotate
分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ...
著者Ramon-Maiques, S, Del Cano-Ochoa, F.
登録日2018-08-22
公開日2018-10-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.
J. Biol. Chem., 293, 2018

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