5V1T
 
 | | Crystal structure of Streptococcus suis SuiB bound to precursor peptide SuiA | | Descriptor: | IRON/SULFUR CLUSTER, METHIONINE, Radical SAM, ... | | Authors: | Davis, K.M, Bacik, J.P, Ando, N. | | Deposit date: | 2017-03-02 | | Release date: | 2017-08-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5V1S
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5V1Q
 | | Crystal structure of Streptococcus suis SuiB | | Descriptor: | IRON/SULFUR CLUSTER, Radical SAM | | Authors: | Davis, K.M, Bacik, J.P, Ando, N. | | Deposit date: | 2017-03-02 | | Release date: | 2017-08-30 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6VP5
 | | Ethylene forming enzyme (EFE) D191E variant in complex with Fe(II), L-arginine, and 2OG | | Descriptor: | 2-OXOGLUTARIC ACID, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ... | | Authors: | Davis, K.M, Copeland, R.A, Boal, A.K. | | Deposit date: | 2020-02-01 | | Release date: | 2021-02-03 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | An Iron(IV)-Oxo Intermediate Initiating l-Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme.
J.Am.Chem.Soc., 143, 2021
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6VP4
 | | Ethylene forming enzyme (EFE) in complex with Fe(II), L-arginine, and 2OG | | Descriptor: | 2-OXOGLUTARIC ACID, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ... | | Authors: | Davis, K.M, Copeland, R.A, Boal, A.K. | | Deposit date: | 2020-02-01 | | Release date: | 2021-02-03 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | An Iron(IV)-Oxo Intermediate Initiating l-Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme.
J.Am.Chem.Soc., 143, 2021
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7LTB
 | | Crystal Structure of Keratinicyclin B | | Descriptor: | (2~{S},4~{S},5~{R},6~{S})-4-azanyl-5-methoxy-6-methyl-oxan-2-ol, 3-ammonio-2,3,6-trideoxy-alpha-L-arabino-hexopyranose-(1-2)-beta-D-glucopyranose, FORMIC ACID, ... | | Authors: | Davis, K.M, Jeffrey, P.D, Seyedsayamdost, M.R. | | Deposit date: | 2021-02-19 | | Release date: | 2022-12-07 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (0.95 Å) | | Cite: | Potent and specific antibiotic combination therapy against Clostridioides difficile.
Nat.Chem.Biol., 20, 2024
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7LKC
 | | Crystal Structure of Keratinimicin A | | Descriptor: | (2~{S},4~{S},5~{R},6~{S})-4-azanyl-5-methoxy-6-methyl-oxan-2-ol, CHLORIDE ION, FORMIC ACID, ... | | Authors: | Davis, K.M, Jeffrey, P.D, Seyedsayamdost, M.R. | | Deposit date: | 2021-02-02 | | Release date: | 2022-12-07 | | Last modified: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (0.95 Å) | | Cite: | Potent and specific antibiotic combination therapy against Clostridioides difficile.
Nat.Chem.Biol., 20, 2024
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6EDH
 | | Taurine:2OG dioxygenase (TauD) bound to the vanadyl ion, taurine, and succinate | | Descriptor: | 2-AMINOETHANESULFONIC ACID, ACETATE ION, Alpha-ketoglutarate-dependent taurine dioxygenase, ... | | Authors: | Davis, K.M, Altmyer, M, Boal, A.K. | | Deposit date: | 2018-08-09 | | Release date: | 2019-08-21 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.73000407 Å) | | Cite: | Structure of a Ferryl Mimic in the Archetypal Iron(II)- and 2-(Oxo)-glutarate-Dependent Dioxygenase, TauD.
Biochemistry, 58, 2019
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4B2Q
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2JK1
 | | Crystal structure of the wild-type HupR receiver domain | | Descriptor: | HYDROGENASE TRANSCRIPTIONAL REGULATORY PROTEIN HUPR1, MAGNESIUM ION | | Authors: | Davies, K.M, Lowe, E.D, Venien-Bryan, C, Johnson, L.N. | | Deposit date: | 2008-05-26 | | Release date: | 2008-11-11 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Hupr Receiver Domain Crystal Structure in its Nonphospho and Inhibitory Phospho States.
J.Mol.Biol., 385, 2009
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2VUH
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2VUI
 | | Crystal structure of the HupR receiver domain in inhibitory phospho- state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, HYDROGENASE TRANSCRIPTIONAL REGULATORY PROTEIN HUPR1, MAGNESIUM ION | | Authors: | Davies, K.M, Lowe, E.D, Venien-Bryan, C, Johnson, L.N. | | Deposit date: | 2008-05-26 | | Release date: | 2008-11-11 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The Hupr Receiver Domain Crystal Structure in its Nonphospho and Inhibitory Phospho States.
J.Mol.Biol., 385, 2009
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9EBX
 | | Chimeric fluorescence biosensor formed from a lactate-binding protein and GFP | | Descriptor: | Green fluorescent protein,Methyl-accepting chemotaxis transducer (TlpC) | | Authors: | Horwitz, S.M, Ambarian, J.A, Waidmann, L, Davis, K.M. | | Deposit date: | 2024-11-13 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | State-dependent motion of a genetically encoded fluorescent biosensor.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8VIH
 | | EgtB-IV from Crocosphaera subtropica, an ergothioneine-biosynthetic type IV sulfoxide synthase in complex with hercynine | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA.
Structure, 32, 2024
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8VII
 | | EgtB-IV from Crocosphaera subtropica, an ergothioneine-biosynthetic type IV sulfoxide synthase in complex with cysteine and hercynine | | Descriptor: | 1,2-ETHANEDIOL, CYSTEINE, MANGANESE (II) ION, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.621 Å) | | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA.
Structure, 32, 2024
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8VIG
 | | EgtB-IV from Geminocystis sp. isolate SKYG4, an ergothioneine-biosynthetic type IV sulfoxide synthase in complex with hercynine | | Descriptor: | 1,2-ETHANEDIOL, FE (III) ION, N,N,N-trimethyl-histidine, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA.
Structure, 32, 2024
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8VIL
 | | EgtB-IV from Crocosphaera subtropica, an ergothioneine-biosynthetic type IV sulfoxide synthase in complex with N,N-dimethyl-histidine | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA.
Structure, 32, 2024
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8VIK
 | | EgtB-IV from Crocosphaera subtropica, a type IV sulfoxide synthase involved in ergothioneine biosynthesis | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.961 Å) | | Cite: | Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA.
Structure, 32, 2024
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9BXH
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9BXJ
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9BXL
 | | OvoM from Sulfuricurvum sp. isolate STB_99, an ovothiol-biosynthetic N-methyltransferase in complex with SAM | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-thiohistidine N-methyltransferase OvoM, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-05-22 | | Release date: | 2025-01-08 | | Last modified: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Structural and functional analysis of SAM-dependent N-methyltransferases involved in ovoselenol and ovothiol biosynthesis.
Structure, 33, 2025
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9BXM
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9BXN
 | | OvoM from Sulfuricurvum sp. isolate STB_99, an ovothiol-biosynthetic N-methyltransferase in complex with 5-thiohistidine and SAH | | Descriptor: | 1,2-ETHANEDIOL, 5-sulfanyl-L-histidine, 5-thiohistidine N-methyltransferase OvoM, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-05-22 | | Release date: | 2025-01-08 | | Last modified: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural and functional analysis of SAM-dependent N-methyltransferases involved in ovoselenol and ovothiol biosynthesis.
Structure, 33, 2025
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9BXK
 | | OvsM from Marinimicrobium koreense, an ovoselenol-biosynthetic N-methyltransferase in complex with 5-selenohistidine and SAH | | Descriptor: | 1,2-ETHANEDIOL, 5-selanyl-L-histidine, 5-selenohistidine N-methyltransferase OvsM, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-05-22 | | Release date: | 2025-01-08 | | Last modified: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Structural and functional analysis of SAM-dependent N-methyltransferases involved in ovoselenol and ovothiol biosynthesis.
Structure, 33, 2025
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9CJG
 | | P450-G9 from Actinokineospora terrae, a non-canonical, serine-ligated cytochrome P450 in the ligand-free, closed conformation | | Descriptor: | 1-BUTANOL, Cytochrome P450-G9, FORMIC ACID, ... | | Authors: | Ireland, K.A, Davis, K.M. | | Deposit date: | 2024-07-06 | | Release date: | 2025-03-12 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Non-Canonical Cytochrome P450 Enzymes in Nature.
Biorxiv, 2024
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