6MJ5
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![BU of 6mj5 by Molmil](/molmil-images/mine/6mj5) | Crystal structure of Tdp1 catalytic domain in complex with compound XZ519 | Descriptor: | 1,2-ETHANEDIOL, 4-hydroxy-8-nitroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | Authors: | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | Deposit date: | 2018-09-20 | Release date: | 2019-07-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.853 Å) | Cite: | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
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6MJP
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![BU of 6mjp by Molmil](/molmil-images/mine/6mjp) | LptB(E163Q)FGC from Vibrio cholerae | Descriptor: | 2-(2-ETHOXYETHOXY)ETHANOL, 6-cyclohexylhexyl beta-D-glucopyranoside, ABC transporter ATP-binding protein, ... | Authors: | Owens, T.W, Kahne, D, Kruse, A.C. | Deposit date: | 2018-09-21 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature, 567, 2019
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5A9G
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![BU of 5a9g by Molmil](/molmil-images/mine/5a9g) | Manganese Superoxide Dismutase from Sphingobacterium sp. T2 | Descriptor: | MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE | Authors: | Rashid, G.M.M, Taylor, C.R, Liu, Y, Zhang, X, Rea, D, Fulop, V, Bugg, T.D.H. | Deposit date: | 2015-07-21 | Release date: | 2015-08-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Identification of Manganese Superoxide Dismutase from Sphingobacterium Sp. T2 as a Novel Bacterial Enzyme for Lignin Oxidation. Acs Chem.Biol., 10, 2015
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6YDH
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6YZ0
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![BU of 6yz0 by Molmil](/molmil-images/mine/6yz0) | Full length Open-form Sodium Channel NavMs F208L in complex with Cannabidiol (CBD) | Descriptor: | 2-[(1R,2R,5S)-5-methyl-2-(prop-1-en-2-yl)cyclohexyl]-5-pentylbenzene-1,3-diol, DODECAETHYLENE GLYCOL, HEGA-10, ... | Authors: | Sula, A, Sait, L.G, Hollingworth, D, Wallace, B.A. | Deposit date: | 2020-05-06 | Release date: | 2020-11-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cannabidiol interactions with voltage-gated sodium channels. Elife, 9, 2020
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6V9V
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![BU of 6v9v by Molmil](/molmil-images/mine/6v9v) | Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily A member 1, ~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide | Authors: | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | Deposit date: | 2019-12-16 | Release date: | 2020-05-06 | Last modified: | 2020-09-16 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature, 585, 2020
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5A2G
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![BU of 5a2g by Molmil](/molmil-images/mine/5a2g) | An esterase from anaerobic Clostridium hathewayi can hydrolyze aliphatic aromatic polyesters | Descriptor: | CARBOXYLIC ESTER HYDROLASE, PHOSPHATE ION | Authors: | Hromic, A, Pavkov Keller, T, Steinkellner, G, Gruber, K, Perz, V, Baumschlager, A, Bleymaier, K, Zitzenbacher, S, Zankel, A, Mayrhofer, C, Sinkel, C, Kueper, U, Schlegel, K.A, Ribitsch, D, Guebitz, G.M. | Deposit date: | 2015-05-19 | Release date: | 2016-02-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.899 Å) | Cite: | An Esterase from Anaerobic Clostridium Hathewayi Can Hydrolyze Aliphatic-Aromatic Polyesters. Environ.Sci.Tech., 50, 2016
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6V9A
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![BU of 6v9a by Molmil](/molmil-images/mine/6v9a) | Agrobacterium tumefaciens ADP-Glucose pyrophosphorylase-S72D | Descriptor: | CITRIC ACID, GLYCEROL, Glucose-1-phosphate adenylyltransferase | Authors: | Zheng, Y, Alghamdi, M.A, Ballicora, M.A, Liu, D. | Deposit date: | 2019-12-13 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Site-directed mutagenesis of Serine-72 reveals the location of the fructose 6-phosphate regulatory site of the Agrobacterium tumefaciens ADP-glucose pyrophosphorylase. Protein Sci., 31, 2022
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6VB4
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![BU of 6vb4 by Molmil](/molmil-images/mine/6vb4) | HLA-B*15:02 complexed with a synthetic peptide | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Beta-2-microglobulin, ... | Authors: | Schutte, R.J, Li, D, Andring, J, McKenna, R, Ostrov, D.A. | Deposit date: | 2019-12-18 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.334 Å) | Cite: | HLA-B*15:02 complexed with a synthetic peptide To Be Published
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6YU6
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![BU of 6yu6 by Molmil](/molmil-images/mine/6yu6) | Crystal structure of MhsT in complex with L-leucine | Descriptor: | DODECYL-BETA-D-MALTOSIDE, LEUCINE, SODIUM ION, ... | Authors: | Focht, D, Neumann, C, Lyons, J, Eguskiza Bilbao, A, Blunck, R, Malinauskaite, L, Schwarz, I.O, Javitch, J.A, Quick, M, Nissen, P. | Deposit date: | 2020-04-25 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition. Embo J., 40, 2021
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6Z3P
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![BU of 6z3p by Molmil](/molmil-images/mine/6z3p) | Structure of EV71 in complex with a protective antibody 38-3-11A Fab | Descriptor: | SPHINGOSINE, VP1, VP2, ... | Authors: | Zhou, D, Fry, E.E, Ren, J, Stuart, D.I. | Deposit date: | 2020-05-21 | Release date: | 2020-09-02 | Last modified: | 2020-10-28 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71. Nat Commun, 11, 2020
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6YYI
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![BU of 6yyi by Molmil](/molmil-images/mine/6yyi) | Crystal structure of beta-D-xylosidase from Dictyoglomus thermophilum bound to beta-D-xylopyranose | Descriptor: | 1,2-ETHANEDIOL, Beta-xylosidase, CITRIC ACID, ... | Authors: | Lafite, P, Daniellou, R, Bretagne, D. | Deposit date: | 2020-05-05 | Release date: | 2020-12-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Crystal structure of Dictyoglomus thermophilum beta-d-xylosidase DtXyl unravels the structural determinants for efficient notoginsenoside R1 hydrolysis. Biochimie, 181, 2020
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5DAJ
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![BU of 5daj by Molmil](/molmil-images/mine/5daj) | Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa | Descriptor: | NalD | Authors: | Chen, W.Z, Wang, D, Huang, S.Q, Hu, Q.Y, Liu, X.C, Gan, J.H, Chen, H. | Deposit date: | 2015-08-20 | Release date: | 2016-04-20 | Last modified: | 2023-04-12 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa Mol.Microbiol., 100, 2016
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6Z4B
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![BU of 6z4b by Molmil](/molmil-images/mine/6z4b) | Crystal Structure of EGFR-T790M/V948R in Complex with Osimertinib and EAI045 | Descriptor: | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, SULFATE ION, ... | Authors: | Niggenaber, J, Mueller, M.P, Rauh, D. | Deposit date: | 2020-05-25 | Release date: | 2020-11-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands. Acs Med.Chem.Lett., 11, 2020
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6UZQ
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![BU of 6uzq by Molmil](/molmil-images/mine/6uzq) | |
1MDT
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6ZKP
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![BU of 6zkp by Molmil](/molmil-images/mine/6zkp) | Native complex I, open1 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ADENOSINE MONOPHOSPHATE, ... | Authors: | Kampjut, D, Sazanov, L.A. | Deposit date: | 2020-06-30 | Release date: | 2020-10-07 | Last modified: | 2020-11-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The coupling mechanism of mammalian respiratory complex I. Science, 370, 2020
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6ZLC
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![BU of 6zlc by Molmil](/molmil-images/mine/6zlc) | Non-specific dsRNA recognition by wildtype H7N1 RNA-binding domain | Descriptor: | NITRATE ION, Non-structural protein 1, RNA (5'-R(*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*U)-3'), ... | Authors: | Coste, F, Wacquiez, A, Marc, D, Castaing, B. | Deposit date: | 2020-06-30 | Release date: | 2020-10-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and Sequence Determinants Governing the Interactions of RNAs with Influenza A Virus Non-Structural Protein NS1. Viruses, 12, 2020
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5CR1
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![BU of 5cr1 by Molmil](/molmil-images/mine/5cr1) | Crystal structure of TTR/resveratrol/T4 complex | Descriptor: | 3,5,3',5'-TETRAIODO-L-THYRONINE, RESVERATROL, Transthyretin | Authors: | Zanotti, G, Florio, P, Folli, C, Cianci, M, Del Rio, D, Berni, R. | Deposit date: | 2015-07-22 | Release date: | 2015-10-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.545 Å) | Cite: | Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites. J.Biol.Chem., 290, 2015
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6YWP
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![BU of 6ywp by Molmil](/molmil-images/mine/6ywp) | Structure of apo-CutA | Descriptor: | CutA, MAGNESIUM ION | Authors: | Malik, D, Kobylecki, K, Krawczyk, P, Poznanski, J, Jakielaszek, A, Napiorkowska, A, Dziembowski, A, Tomecki, R, Nowotny, M. | Deposit date: | 2020-04-29 | Release date: | 2020-08-05 | Last modified: | 2020-09-30 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine. Nucleic Acids Res., 48, 2020
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1MZN
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![BU of 1mzn by Molmil](/molmil-images/mine/1mzn) | CRYSTAL STRUCTURE at 1.9 ANGSTROEMS RESOLUTION OF THE HOMODIMER OF HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO THE SYNTHETIC AGONIST COMPOUND BMS 649 AND A COACTIVATOR PEPTIDE | Descriptor: | 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID, Nuclear receptor coactivator 2, RXR retinoid X receptor | Authors: | Egea, P.F, Mitschler, A, Moras, D. | Deposit date: | 2002-10-09 | Release date: | 2002-10-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Recognition of Agonist Ligands by RXRs MOL.ENDOCRINOL., 16, 2002
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6MTO
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![BU of 6mto by Molmil](/molmil-images/mine/6mto) | Crystal structure of VRC42.01 Fab in complex with T117-F MPER scaffold | Descriptor: | Antibody VRC42.01 Fab heavy chain, Antibody VRC42.01 Fab light chain, VRC42 epitope T117-F scaffold | Authors: | Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Zhang, B, Doria-Rose, N.A, Kwong, P.D. | Deposit date: | 2018-10-21 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.634 Å) | Cite: | Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50, 2019
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6YUP
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![BU of 6yup by Molmil](/molmil-images/mine/6yup) | Heterotetrameric structure of the rBAT-b(0,+)AT1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neutral and basic amino acid transport protein rBAT, ... | Authors: | Wu, D, Safarian, S, Michel, H. | Deposit date: | 2020-04-27 | Release date: | 2021-01-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proc.Natl.Acad.Sci.USA, 117, 2020
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6YXY
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![BU of 6yxy by Molmil](/molmil-images/mine/6yxy) | State B of the Trypanosoma brucei mitoribosomal large subunit assembly intermediate | Descriptor: | 12S ribosomal RNA, ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Jaskolowski, M, Ramrath, D.J.F, Bieri, P, Niemann, M, Mattei, S, Calderaro, S, Leibundgut, M.A, Horn, E.K, Boehringer, D, Schneider, A, Ban, N. | Deposit date: | 2020-05-04 | Release date: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis. Mol.Cell, 79, 2020
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6MTR
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![BU of 6mtr by Molmil](/molmil-images/mine/6mtr) | Crystal structure of VRC43.01 Fab | Descriptor: | Antibody VRC43.01 Fab heavy chain, Antibody VRC43.01 Fab light chain | Authors: | Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Zhang, B, Doria-Rose, N.A, Kwong, P.D. | Deposit date: | 2018-10-21 | Release date: | 2019-03-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50, 2019
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