4YN1
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![BU of 4yn1 by Molmil](/molmil-images/mine/4yn1) | THE ATOMIC STRUCTURE OF ANOMALA CUPREA ENTOMOPOXVIRUS (ACEPV) FUSOLIN SPINDLES | 分子名称: | 1,2-ETHANEDIOL, Fusolin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Chiu, E, Bunker, R.D, Metcalf, P. | 登録日 | 2015-03-09 | 公開日 | 2015-04-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization. Proc.Natl.Acad.Sci.USA, 112, 2015
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8OY7
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![BU of 8oy7 by Molmil](/molmil-images/mine/8oy7) | Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (10 nanosecond pump-probe delay) | 分子名称: | COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... | 著者 | Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C. | 登録日 | 2023-05-03 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Time-resolved crystallography captures light-driven DNA repair. Science, 382, 2023
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6W3L
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7TJA
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![BU of 7tja by Molmil](/molmil-images/mine/7tja) | Structure of the Light Harvesting Complex PE545 from Proteomonas sulcata | 分子名称: | 15,16-DIHYDROBILIVERDIN, MAGNESIUM ION, PHYCOERYTHROBILIN, ... | 著者 | Jeffrey, P.D, Spangler, L.C, Scholes, G.D. | 登録日 | 2022-01-15 | 公開日 | 2022-04-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Controllable Phycobilin Modification: An Alternative Photoacclimation Response in Cryptophyte Algae. Acs Cent.Sci., 8, 2022
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8OY4
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![BU of 8oy4 by Molmil](/molmil-images/mine/8oy4) | Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (300 ps pump-probe delay) | 分子名称: | COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... | 著者 | Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C. | 登録日 | 2023-05-03 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Time-resolved crystallography captures light-driven DNA repair. Science, 382, 2023
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8OYB
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![BU of 8oyb by Molmil](/molmil-images/mine/8oyb) | Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (30 microsecond pump-probe delay) | 分子名称: | COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... | 著者 | Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C. | 登録日 | 2023-05-03 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Time-resolved crystallography captures light-driven DNA repair. Science, 382, 2023
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6W4N
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8UGZ
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![BU of 8ugz by Molmil](/molmil-images/mine/8ugz) | Crystal structure of Shewanella benthica Group 1 truncated hemoglobin C51S C71S variant | 分子名称: | CYANIDE ION, Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Schultz, T.D, Martinez, J.E, Siegler, M.A, Schlessman, J.L, Lecomte, J.T.J. | 登録日 | 2023-10-06 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Heme d formation in a Shewanella benthica hemoglobin. J.Inorg.Biochem., 259, 2024
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6WB3
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![BU of 6wb3 by Molmil](/molmil-images/mine/6wb3) | Crystal structure of coiled coil region of human septin 4 | 分子名称: | ACETATE ION, SULFATE ION, Septin-4 | 著者 | Cabrejos, D.A.L, Cavini, I, Sala, F.A, Valadares, N.F, Pereira, H.M, Brandao-Neto, J, Nascimento, A.F.Z, Uson, I, Araujo, A.P.U, Garratt, R.C. | 登録日 | 2020-03-26 | 公開日 | 2021-03-17 | 最終更新日 | 2021-03-24 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Orientational Ambiguity in Septin Coiled Coils and its Structural Basis. J.Mol.Biol., 433, 2021
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7AX0
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![BU of 7ax0 by Molmil](/molmil-images/mine/7ax0) | Crystal structure of the computationally designed Scone-E protein co-crystallized with STA form a | 分子名称: | Keggin (STA), PHOSPHATE ION, SconeE | 著者 | Mylemans, B, Vandebroek, L, Parac-Vogt, T.N, Voet, A.R.D. | 登録日 | 2020-11-09 | 公開日 | 2021-06-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of Scone: pseudosymmetric folding of a symmetric designer protein. Acta Crystallogr D Struct Biol, 77, 2021
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7NTH
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![BU of 7nth by Molmil](/molmil-images/mine/7nth) | Structure of TAK1 in complex with compound 54 | 分子名称: | 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{R})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{H}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | 登録日 | 2021-03-09 | 公開日 | 2021-04-07 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7NTI
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![BU of 7nti by Molmil](/molmil-images/mine/7nti) | Structure of TAK1 in complex with compound 22 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, ... | 著者 | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | 登録日 | 2021-03-09 | 公開日 | 2021-04-07 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7AFL
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![BU of 7afl by Molmil](/molmil-images/mine/7afl) | Bacterial 30S ribosomal subunit assembly complex state D (multibody refinement for body domain of 30S ribosome) | 分子名称: | 16SrRNA, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | 著者 | Schedlbauer, A, Iturrioz, I, Ochoa-Lizarralde, B, Diercks, T, Kaminishi, T, Capuni, R, Astigarraga, E, Gil-Carton, D, Fucini, P, Connell, S. | 登録日 | 2020-09-19 | 公開日 | 2021-07-07 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | A conserved rRNA switch is central to decoding site maturation on the small ribosomal subunit. Sci Adv, 7, 2021
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6NV7
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![BU of 6nv7 by Molmil](/molmil-images/mine/6nv7) | BACE1 in complex with a macrocyclic inhibitor | 分子名称: | (E)-N-(2-methylpropylidene)-N~2~-{[(4S)-17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl}-D-threoninamide, Beta-secretase 1 | 著者 | Yen, Y.C, Ghosh, A.K, Mesecar, A.D. | 登録日 | 2019-02-04 | 公開日 | 2019-10-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.132 Å) | 主引用文献 | Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors. Biochemistry, 58, 2019
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8E3M
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![BU of 8e3m by Molmil](/molmil-images/mine/8e3m) | E. coli 50S ribosome bound to L-linker solithromycin conjugate | 分子名称: | 50S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2022-08-17 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.25 Å) | 主引用文献 | Solithromycin siderophore conjugates To Be Published
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8W20
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![BU of 8w20 by Molmil](/molmil-images/mine/8w20) | Umb1 umbrella toxin particle | 分子名称: | Intein C-terminal splicing domain-containing protein, Secreted esterase, Secreted protein | 著者 | Park, Y.J, Zhao, Q, Seattle Structural Genomics Center for Infectious Disease (SSGCID), DiMaio, F, Mougous, J.D, Veesler, D. | 登録日 | 2024-02-19 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Streptomyces umbrella toxin particles block hyphal growth of competing species. Nature, 629, 2024
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8FYX
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![BU of 8fyx by Molmil](/molmil-images/mine/8fyx) | Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | 分子名称: | Buspirone, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | 登録日 | 2023-01-26 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
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8E3O
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![BU of 8e3o by Molmil](/molmil-images/mine/8e3o) | E. coli 50S ribosome bound to solithromycin and VM1 | 分子名称: | (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2022-08-17 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (1.99 Å) | 主引用文献 | Solithromycin siderophore conjugates To Be Published
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6Q45
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![BU of 6q45 by Molmil](/molmil-images/mine/6q45) | F1-ATPase from Fusobacterium nucleatum | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Petri, J, Nakatani, Y, Montgomery, M.G, Ferguson, S.A, Aragao, D, Leslie, A.G.W, Heikal, A, Walker, J.E, Cook, G.M. | 登録日 | 2018-12-05 | 公開日 | 2019-07-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum. Open Biology, 9, 2019
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7RH7
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![BU of 7rh7 by Molmil](/molmil-images/mine/7rh7) | Mycobacterial CIII2CIV2 supercomplex, Telacebec (Q203) bound | 分子名称: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | 著者 | Di Trani, J.M, Yanofsky, D.J, Rubinstein, J.L. | 登録日 | 2021-07-16 | 公開日 | 2021-08-04 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of mycobacterial CIII 2 CIV 2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203). Elife, 10, 2021
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8VHB
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![BU of 8vhb by Molmil](/molmil-images/mine/8vhb) | Crystal Structure of Human IDH1 R132Q in complex with NADPH and Alpha-Ketoglutarate | 分子名称: | (3~{S})-3-[(4~{S})-3-aminocarbonyl-1-[(2~{R},3~{R},4~{S},5~{R})-5-[[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4~{H}-pyridin-4-yl]-2-oxidanylidene-pentanedioic acid, 2-OXOGLUTARIC ACID, CALCIUM ION, ... | 著者 | Mealka, M, Sohl, C.D, Huxford, T. | 登録日 | 2023-12-31 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun, 15, 2024
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7R7T
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![BU of 7r7t by Molmil](/molmil-images/mine/7r7t) | p47-bound p97-R155H mutant with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, NSFL1 cofactor p47, Transitional endoplasmic reticulum ATPase | 著者 | Nandi, P, Li, S, Coulmbres, R.C.A, Wang, F, Williams, D.R, Malyutin, A.G, Poh, Y.-P, Chou, T.-F, Chiu, P.-L. | 登録日 | 2021-06-25 | 公開日 | 2021-08-04 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes. Int J Mol Sci, 22, 2021
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7BM2
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7RH5
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![BU of 7rh5 by Molmil](/molmil-images/mine/7rh5) | Mycobacterial CIII2CIV2 supercomplex, Inhibitor free | 分子名称: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | 著者 | Di Trani, J.M, Yanofsky, D.J, Rubinstein, J.L. | 登録日 | 2021-07-16 | 公開日 | 2021-08-04 | 最終更新日 | 2021-11-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of mycobacterial CIII 2 CIV 2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203). Elife, 10, 2021
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6Y6N
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![BU of 6y6n by Molmil](/molmil-images/mine/6y6n) | Structure of mature activin A with small molecule 2 | 分子名称: | (3~{R})-3,4-dimethyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION | 著者 | McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M. | 登録日 | 2020-02-26 | 公開日 | 2021-01-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion Chem Sci, 11, 2020
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