6WZB
 
 | | Crystal structure of the GltPh V216C-G388C mutant cross-linked with divalent mercury | | 分子名称: | ASPARTIC ACID, Glutamate transporter homolog, MERCURY (II) ION, ... | | 著者 | Chen, I, Font, J, Ryan, R. | | 登録日 | 2020-05-13 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Glutamate transporters have a chloride channel with two hydrophobic gates.
Nature, 591, 2021
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6X01
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3EOD
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3ES2
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5OH1
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Aminoglutethimide | | 分子名称: | (3~{R})-3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione, Cereblon isoform 4, S-Thalidomide, ... | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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5OH9
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thiazolidine-2,4-dione | | 分子名称: | 1,3-thiazole-2,4-dione, Cereblon isoform 4, ZINC ION | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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5OH3
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Ethosuximide | | 分子名称: | (3~{S})-3-ethyl-3-methyl-pyrrolidine-2,5-dione, Cereblon isoform 4, ZINC ION | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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5OHA
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with 2-Thiohydantoin | | 分子名称: | 2-sulfanylideneimidazol-4-one, Cereblon isoform 4, ZINC ION | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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5OH7
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Imidazolidine-2,4-dione (Hydantoin) | | 分子名称: | Cereblon isoform 4, ZINC ION, imidazolidine-2,4-dione | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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5OH4
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Piperidine-2,6-dione (Glutarimide) | | 分子名称: | Cereblon isoform 4, ZINC ION, piperidine-2,6-dione | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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5OH2
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Pyrrolidin-2-one (Butyrolactam) | | 分子名称: | Cereblon isoform 4, ZINC ION, pyrrolidin-2-one | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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5OHB
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Piperidin-2-one (Valerolactam) | | 分子名称: | Cereblon isoform 4, ZINC ION, piperidin-2-one | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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5OH8
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Rolipram | | 分子名称: | Cereblon isoform 4, ROLIPRAM, ZINC ION | | 著者 | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | 登録日 | 2017-07-14 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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1OU9
 | | Structure of SspB, a AAA+ protease delivery protein | | 分子名称: | CALCIUM ION, Stringent starvation protein B homolog | | 著者 | Levchenko, I, Grant, R.A, Wah, D.A, Sauer, R.T, Baker, T.A. | | 登録日 | 2003-03-24 | | 公開日 | 2003-09-23 | | 最終更新日 | 2014-04-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag
Mol.Cell, 12, 2003
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1OUL
 | | Structure of the AAA+ protease delivery protein SspB | | 分子名称: | Stringent starvation protein B homolog | | 著者 | Levchenko, I, Grant, R.A, Wah, D.A, Sauer, R.T, Baker, T.A. | | 登録日 | 2003-03-24 | | 公開日 | 2003-09-23 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag
Mol.Cell, 12, 2003
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1OU8
 | | structure of an AAA+ protease delivery protein in complex with a peptide degradation tag | | 分子名称: | MAGNESIUM ION, Stringent starvation protein B homolog, synthetic ssrA peptide | | 著者 | Levchenko, I, Grant, R.A, Wah, D.A, Sauer, R.T, Baker, T.A. | | 登録日 | 2003-03-24 | | 公開日 | 2003-09-23 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag
Mol.Cell, 12, 2003
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1YFN
 | | Versatile modes of peptide recognition by the AAA+ adaptor protein SspB- the crystal structure of a SspB-RseA complex | | 分子名称: | Sigma-E factor negative regulatory protein, Stringent starvation protein B | | 著者 | Levchenko, I, Grant, R.A, Flynn, J.M, Sauer, R.T, Baker, T.A. | | 登録日 | 2005-01-03 | | 公開日 | 2005-05-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Versatile modes of peptide recognition by the AAA+ adaptor protein SspB
Nat.Struct.Mol.Biol., 12, 2005
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3EQ2
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8ODQ
 | | SufS-SufU complex from Mycobacterium tuberculosis | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Cysteine desulfurase, NITRATE ION, ... | | 著者 | Elchennawi, I, Carpentier, P, Caux, C, Ponge, M, Ollagnier de Choudens, S. | | 登録日 | 2023-03-09 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-06-07 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural and Biochemical Characterization of Mycobacterium tuberculosis Zinc SufU-SufS Complex.
Biomolecules, 13, 2023
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3F79
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3F7A
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5LOF
 | | Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1 | | 分子名称: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid, Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Dokurno, P, Kotschy, A, Szlavik, Z, Murray, J, Davidson, J, Csekei, M, Paczal, A, Szabo, Z, Sipos, S, Radics, G, Proszenyak, A, Balint, B, Ondi, L, Blasko, G, Robertson, A, Surgenor, A, Chen, I, Matassova, N, Smith, J, Pedder, C, Graham, C, Geneste, O. | | 登録日 | 2016-08-09 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Nature, 538, 2016
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5OP4
 | | Structure of CHK1 10-pt. mutant complex with aminopyrimidine LRRK2 inhibitor | | 分子名称: | Serine/threonine-protein kinase Chk1, [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoranyl-5-methoxy-phenyl]-morpholin-4-yl-methanone | | 著者 | Dokurno, P, Williamson, D.S, Acheson-Dossang, P, Chen, I, Murray, J.B, Shaw, T, Surgenor, A.E. | | 登録日 | 2017-08-09 | | 公開日 | 2017-10-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
J. Med. Chem., 60, 2017
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5OPS
 | | Structure of CHK1 10-pt. mutant complex with pyrrolopyridine LRRK2 inhibitor | | 分子名称: | 4-(3-hydroxyphenyl)-1~{H}-pyrrolo[2,3-b]pyridine-3-carbonitrile, Serine/threonine-protein kinase Chk1 | | 著者 | Dokurno, P, Williamson, D.S, Acheson-Dossang, P, Chen, I, Murray, J.B, Shaw, T, Surgenor, A.E. | | 登録日 | 2017-08-10 | | 公開日 | 2017-10-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
J. Med. Chem., 60, 2017
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5OOR
 | | Structure of CHK1 10-pt. mutant complex with staurosporine | | 分子名称: | CHLORIDE ION, STAUROSPORINE, Serine/threonine-protein kinase Chk1 | | 著者 | Dokurno, P, Williamson, D.S, Acheson-Dossang, P, Chen, I, Murray, J.B, Shaw, T, Surgenor, A.E. | | 登録日 | 2017-08-08 | | 公開日 | 2017-10-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
J. Med. Chem., 60, 2017
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