5O46
 
 | | Crystal structure of Iristatin, a secreted salivary cystatin from the hard tick Ixodes ricinus | | 分子名称: | GLYCEROL, Iristatin | | 著者 | Busa, M, Rezacova, P, Kotal, J, Kotsyfakis, M, Mares, M. | | 登録日 | 2017-05-26 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin.
Cell.Mol.Life Sci., 76, 2019
|
|
6I1M
 | | Secreted type 1 cystatin from Fasciola hepatica | | 分子名称: | Cystatin, IODIDE ION | | 著者 | Busa, M, Rezacova, P, Pachl, P, Stefanic, S, Mares, M. | | 登録日 | 2018-10-29 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-03-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily.
J.Biol.Chem., 299, 2023
|
|
7NXM
 | | Structure of human cathepsin K in complex with the selective activity-based probe Gu3416 | | 分子名称: | Cathepsin K, N-(4-(dibenzylamino)-4-oxobutyl)-2-(5-(dimethylamino)pentanamido)-4-methylpentanamide, SULFATE ION | | 著者 | Busa, M, Benysek, J, Lemke, C, Gutschow, M, Mares, M. | | 登録日 | 2021-03-18 | | 公開日 | 2021-09-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
J.Med.Chem., 64, 2021
|
|
7NXL
 | | Structure of human cathepsin K in complex with the acrylamide inhibitor Gu3110 | | 分子名称: | Cathepsin K, SULFATE ION, tert-butyl (1-((4-(dibenzylamino)-4-oxobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate | | 著者 | Busa, M, Benysek, J, Lemke, C, Gutschow, M, Mares, M. | | 登録日 | 2021-03-18 | | 公開日 | 2021-09-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
J.Med.Chem., 64, 2021
|
|
6ZTK
 | | Crystal structure of Mialostatin, a gut cystatin from the hard tick Ixodes ricinus | | 分子名称: | FRAGMENT OF TRITON X-100, Mialostatin, SULFATE ION | | 著者 | Busa, M, Rezacova, P, Mares, M. | | 登録日 | 2020-07-20 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion.
Int J Mol Sci, 22, 2021
|
|
7PK4
 | |
7QBN
 | | Structure of cathepsin K in complex with the azadipeptide nitrile inhibitor Gu1303 | | 分子名称: | (phenylmethyl) ~{N}-[(2~{S})-1-[[aminomethyl(methyl)amino]-methyl-amino]-1-oxidanylidene-3-phenyl-propan-2-yl]carbamate, ACETATE ION, CHLORIDE ION, ... | | 著者 | Benysek, J, Busa, M, Mares, M. | | 登録日 | 2021-11-19 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
J Enzyme Inhib Med Chem, 37, 2022
|
|
7QBM
 | | Structure of the activation intermediate of cathepsin K in complex with the 3-cyano-3-aza-beta-amino acid inhibitor Gu2602 | | 分子名称: | ACETATE ION, Cathepsin K, MAGNESIUM ION, ... | | 著者 | Benysek, J, Busa, M, Mares, M. | | 登録日 | 2021-11-19 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
J Enzyme Inhib Med Chem, 37, 2022
|
|
7QBL
 | |
7QBO
 | | Structure of the activation intermediate of cathepsin K in complex with the azadipeptide nitrile inhibitor Gu1303 | | 分子名称: | (phenylmethyl) ~{N}-[(2~{S})-1-[[aminomethyl(methyl)amino]-methyl-amino]-1-oxidanylidene-3-phenyl-propan-2-yl]carbamate, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Benysek, J, Busa, M, Mares, M. | | 登録日 | 2021-11-19 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
J Enzyme Inhib Med Chem, 37, 2022
|
|
