6OF0
 
 | | Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae | | 分子名称: | HTH-type transcriptional regulator MtrR, PHOSPHATE ION | | 著者 | Beggs, G.A, Kumaraswami, M, Shafer, W, Brennan, R.G. | | 登録日 | 2019-03-28 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae .
J.Bacteriol., 201, 2019
|
|
7LQ2
 | |
7LQ4
 | | Rr (RsiG)2-(c-di-GMP)2-WhiG complex | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), RsiG, WhiG | | 著者 | Schumacher, M.A, Brennan, R.G. | | 登録日 | 2021-02-12 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Evolution of a sigma-(c-di-GMP)-anti-sigma switch.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7LQ3
 | |
6WMT
 | | F. tularensis RNAPs70-(MglA-SspA)-ppGpp-PigR-iglA DNA complex | | 分子名称: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | | 著者 | Travis, B.A, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2020-04-21 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.43 Å) | | 主引用文献 | Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
|
|
6WMP
 | | F. tularensis RNAPs70-iglA DNA complex | | 分子名称: | DNA NT-strand, DNA T-strand, DNA-directed RNA polymerase subunit alpha 1, ... | | 著者 | Travis, B.A, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2020-04-21 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
|
|
6WMU
 | | E. coli RNAPs70-SspA-gadA DNA complex | | 分子名称: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | | 著者 | Travis, B.A, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2020-04-21 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
|
|
6WMR
 | | F. tularensis RNAPs70-(MglA-SspA)-iglA DNA complex | | 分子名称: | DNA NT-strand, DNA NT-strand downstream, DNA T-strand, ... | | 著者 | Travis, B.A, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2020-04-21 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Structural Basis for Virulence Activation of Francisella tularensis.
Mol.Cell, 81, 2021
|
|
3IHQ
 | |
1WET
 | | STRUCTURE OF THE PURR-GUANINE-PURF OPERATOR COMPLEX | | 分子名称: | DNA (5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR) | | 著者 | Schumacher, M.A, Glasfeld, A, Zalkin, H, Brennan, R.G. | | 登録日 | 1997-04-27 | | 公開日 | 1997-11-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity.
J.Biol.Chem., 272, 1997
|
|
3OQM
 | | structure of ccpa-hpr-ser46p-ackA2 complex | | 分子名称: | 5'-D(*TP*TP*GP*AP*TP*AP*AP*CP*GP*CP*TP*TP*AP*CP*AP*A)-3', 5'-D(*TP*TP*GP*TP*AP*AP*GP*CP*GP*TP*TP*AP*TP*CP*AP*A)-3', Catabolite control protein A, ... | | 著者 | Schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | | 登録日 | 2010-09-03 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | | 主引用文献 | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.
Nucleic Acids Res., 39, 2011
|
|
3OQN
 | | Structure of ccpa-hpr-ser46-p-gntr-down cre | | 分子名称: | 5'-D(*AP*TP*GP*GP*TP*AP*CP*CP*GP*CP*TP*TP*TP*CP*AP*A)-3', 5'-D(*TP*TP*GP*AP*AP*AP*GP*CP*GP*GP*TP*AP*CP*CP*AP*T)-3', Catabolite control protein A, ... | | 著者 | Schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | | 登録日 | 2010-09-03 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.
Nucleic Acids Res., 39, 2011
|
|
3OQO
 | | Ccpa-hpr-ser46p-syn cre | | 分子名称: | 5'-D(*CP*TP*GP*AP*AP*AP*GP*CP*GP*CP*TP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*AP*GP*CP*GP*CP*TP*TP*TP*CP*AP*G)-3', Catabolite control protein A, ... | | 著者 | schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | | 登録日 | 2010-09-03 | | 公開日 | 2011-10-26 | | 最終更新日 | 2014-04-09 | | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | | 主引用文献 | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.
Nucleic Acids Res., 39, 2011
|
|
2HQ5
 | |
2H1O
 | | Structure of FitAB bound to IR36 DNA fragment | | 分子名称: | IR36-strand 1, IR36-strand 2, Trafficking protein A, ... | | 著者 | Mattison, K, Wilbur, J.S, So, M, Brennan, R.G. | | 登録日 | 2006-05-16 | | 公開日 | 2006-09-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.
J.Biol.Chem., 281, 2006
|
|
2PUE
 | | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | | 分子名称: | ADENINE, DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), PROTEIN (PURINE REPRESSOR ) | | 著者 | Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G. | | 登録日 | 1997-10-04 | | 公開日 | 1998-05-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
Biochemistry, 37, 1998
|
|
1HAB
 | | CROSSLINKED HAEMOGLOBIN | | 分子名称: | 4-CARBOXYCINNAMIC ACID, CARBON MONOXIDE, HEMOGLOBIN A, ... | | 著者 | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | | 登録日 | 1996-03-13 | | 公開日 | 1997-11-12 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Allosteric intermediates indicate R2 is the liganded hemoglobin end state.
Proc.Natl.Acad.Sci.USA, 94, 1997
|
|
1HAC
 | | CROSSLINKED HAEMOGLOBIN | | 分子名称: | 2,6-DICARBOXYNAPHTHALENE, CARBON MONOXIDE, HEMOGLOBIN A, ... | | 著者 | Schumacher, M.A, Dixon, M.M, Kluger, R, Jones, R.T, Brennan, R.G. | | 登録日 | 1996-03-13 | | 公開日 | 1997-11-12 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Allosteric intermediates indicate R2 is the liganded hemoglobin end state.
Proc.Natl.Acad.Sci.USA, 94, 1997
|
|
3GIB
 | |
3IAO
 | |
3T03
 | | Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16 | | 分子名称: | (5Z)-5-(5-bromo-2-methoxybenzylidene)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | | 著者 | Rajagopalan, S, Webb, P, Baxter, J.D, Brennan, R.G, Phillips, K.J. | | 登録日 | 2011-07-19 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | GQ-16, a novel peroxisome proliferator-activated receptor (PPAR gamma) ligand, promotes insulin sensitization without weight gain.
J.Biol.Chem., 287, 2012
|
|
3RJP
 | |
1Z3E
 | | Crystal Structure of Spx in Complex with the C-terminal Domain of the RNA Polymerase Alpha Subunit | | 分子名称: | DNA-directed RNA polymerase alpha chain, Regulatory protein spx, SULFATE ION | | 著者 | Newberry, K.J, Nakano, S, Zuber, P, Brennan, R.G. | | 登録日 | 2005-03-11 | | 公開日 | 2005-10-11 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the {alpha} C-terminal domain of RNA polymerase
Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
1ZAY
 | |
3TPE
 | | The phipa p3121 structure | | 分子名称: | Serine/threonine-protein kinase HipA | | 著者 | Schumacher, M.A, Link, T, Brennan, R.G. | | 登録日 | 2011-09-07 | | 公開日 | 2012-10-03 | | 最終更新日 | 2018-03-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance.
Cell Rep, 2, 2012
|
|
