7PHP
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![BU of 7php by Molmil](/molmil-images/mine/7php) | Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM | Descriptor: | Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ... | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2021-08-18 | Release date: | 2021-09-01 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PIJ
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![BU of 7pij by Molmil](/molmil-images/mine/7pij) | Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | Descriptor: | Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ... | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2021-08-20 | Release date: | 2021-09-01 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHQ
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![BU of 7phq by Molmil](/molmil-images/mine/7phq) | Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | Descriptor: | Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ... | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | Deposit date: | 2021-08-18 | Release date: | 2021-09-01 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (8.45 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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5NO0
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![BU of 5no0 by Molmil](/molmil-images/mine/5no0) | |
7ZLJ
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![BU of 7zlj by Molmil](/molmil-images/mine/7zlj) | Cryo-EM structure of C-mannosyltransferase CeDPY19, in ternary complex with Dol25-P-C-Man and acceptor peptide, bound to CMT2-Fab and anti-Fab nanobody | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | Authors: | Bloch, J.S, Mao, R, Mukherjee, S, Boilevin, J, Irobalieva, R, Darbre, T, Reymond, J.L, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | Deposit date: | 2022-04-15 | Release date: | 2023-01-11 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nat.Chem.Biol., 19, 2023
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7ZLI
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![BU of 7zli by Molmil](/molmil-images/mine/7zli) | Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with Dol25-P-Man and bound to CMT2-Fab and anti-Fab nanobody | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | Authors: | Bloch, J.S, Mukherjee, S, Boilevin, J, Irobalieva, R, Darbre, T, Reymond, J.L, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | Deposit date: | 2022-04-15 | Release date: | 2023-01-11 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nat.Chem.Biol., 19, 2023
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6SNI
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![BU of 6sni by Molmil](/molmil-images/mine/6sni) | Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab | Descriptor: | 6AG9-Fab heavy chain, 6AG9-Fab light chain, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | Deposit date: | 2019-08-24 | Release date: | 2020-03-11 | Last modified: | 2020-04-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579, 2020
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6SNH
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![BU of 6snh by Molmil](/molmil-images/mine/6snh) | Cryo-EM structure of yeast ALG6 in complex with 6AG9 Fab and Dol25-P-Glc | Descriptor: | 6AG9 Fab heavy chain, 6AG9 Fab light chain, Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, ... | Authors: | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | Deposit date: | 2019-08-24 | Release date: | 2020-03-11 | Last modified: | 2020-04-01 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579, 2020
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7QBG
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![BU of 7qbg by Molmil](/molmil-images/mine/7qbg) | TC:CD320 in complex with nanobody TC-Nb4 | Descriptor: | Anti-TC:CD320 nanobody TC-Nb4, CALCIUM ION, CD320 antigen, ... | Authors: | Bloch, J.S, Locher, K.P. | Deposit date: | 2021-11-19 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route. Faseb J., 36, 2022
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7QBD
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![BU of 7qbd by Molmil](/molmil-images/mine/7qbd) | TC:CD320 in complex with nanobody TC-Nb26 | Descriptor: | Antitranscobalamin-nanobody TC-Nb26, CALCIUM ION, CD320 antigen, ... | Authors: | Bloch, J.S, Locher, K.P. | Deposit date: | 2021-11-19 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.18 Å) | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route. Faseb J., 36, 2022
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7QBF
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![BU of 7qbf by Molmil](/molmil-images/mine/7qbf) | TC:CD320 in complex with nanobody TC-Nb34 | Descriptor: | 1,2-ETHANEDIOL, Anti-transcobalamin-2 nanobody TC-Nb34, CALCIUM ION, ... | Authors: | Bloch, J.S, Locher, K.P. | Deposit date: | 2021-11-19 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route. Faseb J., 36, 2022
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7QBE
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![BU of 7qbe by Molmil](/molmil-images/mine/7qbe) | TC:CD320 in complex with nanobody TC-Nb11 | Descriptor: | Anti-transcobalamin-2 nanobody TC-Nb11, CALCIUM ION, CD320 antigen, ... | Authors: | Bloch, J.S, Locher, K.P. | Deposit date: | 2021-11-19 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route. Faseb J., 36, 2022
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7ZLG
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![BU of 7zlg by Molmil](/molmil-images/mine/7zlg) | Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with acceptor peptide and bound to CMT2-Fab and anti-Fab nanobody | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | Authors: | Bloch, J.S, Mukherjee, S, Mao, R, Irobalieva, R, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | Deposit date: | 2022-04-15 | Release date: | 2023-01-11 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nat.Chem.Biol., 19, 2023
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7ZLH
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![BU of 7zlh by Molmil](/molmil-images/mine/7zlh) | Cryo-EM structure of C-mannosyltransferase CeDPY19, in apo state, bound to CMT2-Fab and anti-Fab nanobody | Descriptor: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | Authors: | Bloch, J.S, Mukherjee, S, Irobalieva, R, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | Deposit date: | 2022-04-15 | Release date: | 2023-01-11 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nat.Chem.Biol., 19, 2023
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6SRW
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![BU of 6srw by Molmil](/molmil-images/mine/6srw) | Kemp Eliminase HG3.17 mutant Q50F, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, GLYCEROL, Kemp Eliminase HG3.17 Q50F | Authors: | Bloch, J.S, Pinkas, D.M, Hilvert, D. | Deposit date: | 2019-09-06 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
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6SS1
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![BU of 6ss1 by Molmil](/molmil-images/mine/6ss1) | Kemp Eliminase HG3.17 mutant Q50A, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, Kemp Eliminase HG3.17 Q50A, E47N,N300D Complexed with Transition State Analog 6-Nitrobenzotriazole, ... | Authors: | Bloch, J.S, Pinkas, D.M, Hilvert, D. | Deposit date: | 2019-09-06 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
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6SRY
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![BU of 6sry by Molmil](/molmil-images/mine/6sry) | Kemp Eliminase HG3.17 mutant Q50S, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, Kemp Eliminase HG3.17 Q50S, E47N,N300D, ... | Authors: | Bloch, J.S, Pinkas, D.M, Hilvert, D. | Deposit date: | 2019-09-06 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
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6SS3
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![BU of 6ss3 by Molmil](/molmil-images/mine/6ss3) | Kemp Eliminase HG3.17 mutant Q50K, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, GLYCEROL, Kemp Eliminase HG3.17 Q50K, ... | Authors: | Bloch, J.S, Pinkas, D.M, Hilvert, D. | Deposit date: | 2019-09-06 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
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6SRZ
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![BU of 6srz by Molmil](/molmil-images/mine/6srz) | Kemp Eliminase HG3.17 mutant Q50H, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, GLYCEROL, Kemp Eliminase HG3.17 Q50H, ... | Authors: | Bloch, J.S, Pinkas, D.M, Hilvert, D. | Deposit date: | 2019-09-06 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
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6TU6
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![BU of 6tu6 by Molmil](/molmil-images/mine/6tu6) | |
5NRP
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![BU of 5nrp by Molmil](/molmil-images/mine/5nrp) | |
5NP4
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![BU of 5np4 by Molmil](/molmil-images/mine/5np4) | |
5NSA
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![BU of 5nsa by Molmil](/molmil-images/mine/5nsa) | Beta domain of human transcobalamin bound to Co-beta-[2-(2,4-difluorophenyl)ethinyl]cobalamin | Descriptor: | 1-ethynyl-2,4-difluorobenzene, CALCIUM ION, COBALAMIN, ... | Authors: | Bloch, J.S, Ruetz, M, Krautler, B, Locher, K.P. | Deposit date: | 2017-04-25 | Release date: | 2017-09-27 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.273 Å) | Cite: | Structure of the human transcobalamin beta domain in four distinct states. PLoS ONE, 12, 2017
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7RTH
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![BU of 7rth by Molmil](/molmil-images/mine/7rth) | Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab" | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ... | Authors: | Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A. | Deposit date: | 2021-08-13 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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8AGE
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![BU of 8age by Molmil](/molmil-images/mine/8age) | Structure of yeast oligosaccharylransferase complex with acceptor peptide bound | Descriptor: | (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[3,6-bis(dimethylamino)xanthen-9-yl]-5-methanoyl-benzoate, ... | Authors: | Ramirez, A.S, de Capitani, M, Pesciullesi, G, Kowal, J, Bloch, J.S, Irobalieva, R.N, Aebi, M, Reymond, J.L, Locher, K.P. | Deposit date: | 2022-07-19 | Release date: | 2022-12-07 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nat Commun, 13, 2022
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