5CWD
 
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5CWI
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5CWH
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4W8F
 | | Crystal structure of the dynein motor domain in the AMPPNP-bound state | | 分子名称: | Dynein heavy chain lysozyme chimera, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Cheng, H.-C, Bhabha, G, Zhang, N, Vale, R.D. | | 登録日 | 2014-08-24 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.541 Å) | | 主引用文献 | Allosteric communication in the Dynein motor domain.
Cell, 159, 2014
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7SEE
 | | Structure of E. coli LetB delta (Ring6) mutant, Ring1 in the closed state (Model 1) | | 分子名称: | MCE family protein, Intermembrane transport protein YebT chimera, UNKNOWN ATOM OR ION | | 著者 | Vieni, C, Coudray, N, Bhabha, G, Ekiert, D. | | 登録日 | 2021-09-30 | | 公開日 | 2022-02-09 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Role of Ring6 in the Function of the E. coli MCE Protein LetB.
J.Mol.Biol., 434, 2022
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7SEF
 | | Structure of E. coli LetB delta (Ring6) mutant, Ring 1 in the open state (Model 2, Rings 1-3 only) | | 分子名称: | MCE family protein, Intermembrane transport protein YebT chimera | | 著者 | Vieni, C, Coudray, N, Bhabha, G, Ekiert, D. | | 登録日 | 2021-09-30 | | 公開日 | 2022-02-09 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Role of Ring6 in the Function of the E. coli MCE Protein LetB.
J.Mol.Biol., 434, 2022
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6XBD
 | | Cryo-EM structure of MlaFEDB in nanodiscs with phospholipid substrates | | 分子名称: | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, MSP1D1, Phospholipid ABC transporter permease protein MlaE, ... | | 著者 | Coudray, N, Isom, G.L, MacRae, M.R, Saiduddin, M, Ekiert, D.C, Bhabha, G. | | 登録日 | 2020-06-05 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structure of bacterial phospholipid transporter MlaFEDB with substrate bound.
Elife, 9, 2020
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6XGZ
 | | Crystal structure of E. coli MlaFB ABC transport subunits in the monomeric state | | 分子名称: | 1,2-ETHANEDIOL, ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, ... | | 著者 | Chang, Y, Bhabha, G, Ekiert, D.C. | | 登録日 | 2020-06-18 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation.
Elife, 9, 2020
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6XSS
 | | CryoEM structure of designed helical fusion protein C4_nat_HFuse-7900 | | 分子名称: | C4_nat_HFuse-7900 | | 著者 | Redler, R.L, Edman, N.I, Baker, D, Ekiert, D, Bhabha, G. | | 登録日 | 2020-07-16 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Design of multi-scale protein complexes by hierarchical building block fusion.
Nat Commun, 12, 2021
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2KBU
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8GEL
 | | Cryo-EM structure of synthetic tetrameric building block sC4 | | 分子名称: | sC4 | | 著者 | Redler, R.L, Huddy, T.F, Hsia, Y, Baker, D, Ekiert, D, Bhabha, G. | | 登録日 | 2023-03-07 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Blueprinting extendable nanomaterials with standardized protein blocks.
Nature, 627, 2024
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8F6R
 | | CryoEM structure of designed modular protein oligomer C6-79 | | 分子名称: | De novo designed oligomeric protein C6-79 | | 著者 | Redler, R.L, Edman, N.I, Baker, D, Ekiert, D, Bhabha, G. | | 登録日 | 2022-11-17 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.
Cell, 2024
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8F6Q
 | | CryoEM structure of designed modular protein oligomer C8-71 | | 分子名称: | C8-71 | | 著者 | Redler, R.L, Edman, N.I, Baker, D, Ekiert, D, Bhabha, G. | | 登録日 | 2022-11-17 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.
Biorxiv, 2023
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7JR9
 | | Chlamydomonas reinhardtii radial spoke minimal head complex | | 分子名称: | Flagellar radial spoke protein 10, Flagellar radial spoke protein 4, Flagellar radial spoke protein 6, ... | | 著者 | Grossman-Haham, I, Coudray, N, Yu, Z, Wang, F, Bhabha, G, Vale, R.D. | | 登録日 | 2020-08-11 | | 公開日 | 2020-12-16 | | 最終更新日 | 2021-01-27 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating.
Nat.Struct.Mol.Biol., 28, 2021
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8GLT
 | | Backbone model of de novo-designed chlorophyll-binding nanocage O32-15 | | 分子名称: | C2-chlorophyll-comp_O32-15_ctermHis, polyalanine model, C3-comp_O32-15 | | 著者 | Redler, R.L, Ennist, N.M, Wang, S, Baker, D, Ekiert, D.C, Bhabha, G. | | 登録日 | 2023-03-23 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | De novo design of proteins housing excitonically coupled chlorophyll special pairs.
Nat.Chem.Biol., 20, 2024
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8FED
 | | Structure of Mce1-LucB complex from Mycobacterium smegmatis (Map1) | | 分子名称: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | | 著者 | Chen, J, Bhabha, G, Ekiert, D.C. | | 登録日 | 2022-12-06 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | Structure of an endogenous mycobacterial MCE lipid transporter.
Nature, 620, 2023
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8FEE
 | | Structure of Mce1 transporter from Mycobacterium smegmatis in the absence of LucB (Map2) | | 分子名称: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | | 著者 | Chen, J, Bhabha, G, Ekiert, D.C. | | 登録日 | 2022-12-06 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of an endogenous mycobacterial MCE lipid transporter.
Nature, 620, 2023
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8FEF
 | | Structure of Mce1 transporter from Mycobacterium smegmatis (Map0) | | 分子名称: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | | 著者 | Chen, J, Bhabha, G, Ekiert, D.C. | | 登録日 | 2022-12-06 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | Structure of an endogenous mycobacterial MCE lipid transporter.
Nature, 620, 2023
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4KJL
 | | Room Temperature N23PPS148A DHFR | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | van den Bedem, H, Bhabha, G, Yang, K, Wright, P.E, Fraser, J.S. | | 登録日 | 2013-05-03 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
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4KJJ
 | | Cryogenic WT DHFR | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | van den Bedem, H, Bhabha, G, Yang, K, Wright, P.E, Fraser, J.S. | | 登録日 | 2013-05-03 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
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4KJK
 | | Room Temperature WT DHFR | | 分子名称: | CALCIUM ION, Dihydrofolate reductase, FOLIC ACID, ... | | 著者 | van den Bedem, H, Bhabha, G, Yang, K, Wright, P.E, Fraser, J.S. | | 登録日 | 2013-05-03 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.351 Å) | | 主引用文献 | Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
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7JRJ
 | | Chlamydomonas reinhardtii radial spoke head and neck (recombinant) | | 分子名称: | Flagellar radial spoke protein 1, Flagellar radial spoke protein 10, Flagellar radial spoke protein 2, ... | | 著者 | Grossman-Haham, I, Coudray, N, Yu, Z, Wang, F, Zhang, N, Bhabha, G, Vale, R.D. | | 登録日 | 2020-08-12 | | 公開日 | 2020-12-16 | | 最終更新日 | 2021-01-27 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating.
Nat.Struct.Mol.Biol., 28, 2021
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7MI8
 | | Signal subtracted reconstruction of AAA5 and AAA6 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Model 5 | | 分子名称: | Fusion protein of Dynein and Endolysin | | 著者 | Santarossa, C.C, Coudray, N, Urnavicius, L, Ekiert, D.C, Bhabha, G, Kapoor, T.M. | | 登録日 | 2021-04-16 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021
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7MI6
 | | Yeast dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound, Model 1 | | 分子名称: | (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, Fusion protein of Dynein and Endolysin, ... | | 著者 | Santarossa, C.C, Urnavicius, L, Coudray, N, Ekeirt, D.C, Bhabha, G, Kapoor, T.M. | | 登録日 | 2021-04-16 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021
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7MI3
 | | Signal subtracted reconstruction of AAA2, AAA3, and AAA4 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Model 4 | | 分子名称: | (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, Fusion protein of Dynein and Endolysin, ... | | 著者 | Santarossa, C.C, Coudray, N, Urnavicius, L, Ekiert, D.C, Bhabha, G, Kapoor, T.M. | | 登録日 | 2021-04-16 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Targeting allostery in the Dynein motor domain with small molecule inhibitors.
Cell Chem Biol, 28, 2021
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