6V42
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6V43
| Crystal structure of the flavin oxygenase with cofactor and substrate bound involved in folate catabolism | Descriptor: | FAD/FMN-containing dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, pteridine-2,4(1H,3H)-dione | Authors: | Begley, T.P, Adak, S, Zhao, B, Li, P. | Deposit date: | 2019-11-27 | Release date: | 2020-12-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | A novel flavoenzyme catalyzed Baeyer-Villiger type rearrangement in bacterial folic acid catabolic pathway To Be Published
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5WAN
| Crystal Structure of a flavoenzyme RutA in the pyrimidine catabolic pathway | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, Pyrimidine monooxygenase RutA, ... | Authors: | Zhang, Y, Mukherjee, T, Abdelwahed, S, Begley, T.P, Ealick, S.E. | Deposit date: | 2017-06-26 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Catalysis of a flavoenzyme-mediated amide hydrolysis. J. Am. Chem. Soc., 132, 2010
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5LNT
| Crystal structure of Arabidopsis thaliana Pdx1K166R-preI320 complex | Descriptor: | PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PDX1.1, [(~{E},4~{S})-4-azanyl-3-oxidanylidene-pent-1-enyl] dihydrogen phosphate | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2017-02-22 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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6O9A
| Crystal structure of MqnA complexed with 3-hydroxybenzoic acid | Descriptor: | 3-HYDROXYBENZOIC ACID, ACETATE ION, Chorismate dehydratase | Authors: | Hicks, K.A, Mahanta, N, Naseem, S, Fedoseyenko, D, Begley, T.P, Ealick, S.E. | Deposit date: | 2019-03-13 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.326 Å) | Cite: | Menaquinone Biosynthesis: Biochemical and Structural Studies of Chorismate Dehydratase. Biochemistry, 58, 2019
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5LNS
| Crystal structure of Arabidopsis thaliana Pdx1-R5P complex | Descriptor: | PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PDX1.3, RIBULOSE-5-PHOSPHATE | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2017-02-22 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNU
| Crystal structure of Arabidopsis thaliana Pdx1-I320 complex | Descriptor: | (4~{S})-4-azanyl-5-oxidanyl-pent-1-en-3-one, PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PDX1.3, ... | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2017-02-22 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNR
| Crystal structure of Arabidopsis thaliana Pdx1-PLP complex | Descriptor: | GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, Pyridoxal 5'-phosphate synthase subunit PDX1.3 | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2017-02-22 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNW
| Crystal structure of Arabidopsis thaliana Pdx1-I320-G3P complex | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, GLYCEROL, Pyridoxal 5'-phosphate synthase subunit PDX1.3, ... | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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5LNV
| Crystal structure of Arabidopsis thaliana Pdx1-I320 complex from multiple crystals | Descriptor: | (4~{S})-4-azanyl-5-oxidanyl-pent-1-en-3-one, PHOSPHATE ION, Pyridoxal 5'-phosphate synthase subunit PDX1.3, ... | Authors: | Rodrigues, M.J, Windeisen, V, Zhang, Y, Guedez, G, Weber, S, Strohmeier, M, Hanes, J.W, Royant, A, Evans, G, Sinning, I, Ealick, S.E, Begley, T.P, Tews, I. | Deposit date: | 2016-08-06 | Release date: | 2017-01-18 | Last modified: | 2018-09-19 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat. Chem. Biol., 13, 2017
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2THI
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4GIJ
| Crystal Structure of Pseudouridine Monophosphate Glycosidase Complexed with Sulfate | Descriptor: | MANGANESE (II) ION, Pseudouridine-5'-phosphate glycosidase, SULFATE ION | Authors: | Huang, S, Mahanta, N, Begley, T.P, Ealick, S.E. | Deposit date: | 2012-08-08 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.941 Å) | Cite: | Pseudouridine monophosphate glycosidase: a new glycosidase mechanism. Biochemistry, 51, 2012
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4GIM
| Crystal Structure of Pseudouridine Monophosphate Glycosidase Complexed with Pseudouridine 5'-phosphate | Descriptor: | MANGANESE (II) ION, PSEUDOURIDINE-5'-MONOPHOSPHATE, Pseudouridine-5'-phosphate glycosidase | Authors: | Huang, S, Mahanta, N, Begley, T.P, Ealick, S.E. | Deposit date: | 2012-08-08 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Pseudouridine monophosphate glycosidase: a new glycosidase mechanism. Biochemistry, 51, 2012
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4GIK
| Crystal Structure of Pseudouridine Monophosphate Glycosidase/Linear R5P Adduct | Descriptor: | MANGANESE (II) ION, Pseudouridine-5'-phosphate glycosidase, RIBOSE-5-PHOSPHATE | Authors: | Huang, S, Mahanta, N, Begley, T.P, Ealick, S.E. | Deposit date: | 2012-08-08 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.187 Å) | Cite: | Pseudouridine monophosphate glycosidase: a new glycosidase mechanism. Biochemistry, 51, 2012
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2TPS
| THIAMIN PHOSPHATE SYNTHASE | Descriptor: | MAGNESIUM ION, PROTEIN (THIAMIN PHOSPHATE SYNTHASE), PYROPHOSPHATE 2-, ... | Authors: | Chiu, H.-J, Reddick, J.J, Begley, T.P, Ealick, S.E. | Deposit date: | 1999-03-09 | Release date: | 1999-03-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution. Biochemistry, 38, 1999
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1C3Q
| CRYSTAL STRUCTURE OF NATIVE THIAZOLE KINASE IN THE MONOCLINIC FORM | Descriptor: | 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL, CHLORIDE ION, Hydroxyethylthiazole kinase | Authors: | Campobasso, N, Mathews, I.I, Begley, T.P, Ealick, S.E. | Deposit date: | 1999-07-28 | Release date: | 1999-08-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution. Biochemistry, 39, 2000
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1DBT
| CRYSTAL STRUCTURE OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE FROM BACILLUS SUBTILIS COMPLEXED WITH UMP | Descriptor: | OROTIDINE 5'-PHOSPHATE DECARBOXYLASE, URIDINE-5'-MONOPHOSPHATE | Authors: | Appleby, T.C, Kinsland, C.L, Begley, T.P, Ealick, S.E. | Deposit date: | 1999-11-03 | Release date: | 2000-03-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase. Proc.Natl.Acad.Sci.USA, 97, 2000
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1P9O
| Crystal Structure of Phosphopantothenoylcysteine Synthetase | Descriptor: | Phosphopantothenoylcysteine synthetase, SULFATE ION | Authors: | Manoj, N, Strauss, E, Begley, T.P, Ealick, S.E. | Deposit date: | 2003-05-12 | Release date: | 2003-09-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure, 11, 2003
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1R9G
| Three-dimensional Structure of YaaE from Bacillus subtilis | Descriptor: | Hypothetical protein yaaE | Authors: | Bauer, J.A, Bennett, E.M, Begley, T.P, Ealick, S.E. | Deposit date: | 2003-10-29 | Release date: | 2004-01-27 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Three-dimensional Structure of YaaE from Bacillus subtilis, a Glutaminase Implicated in Pyridoxal-5'-phosphate Biosynthesis. J.Biol.Chem., 279, 2004
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2ISS
| Structure of the PLP synthase Holoenzyme from Thermotoga maritima | Descriptor: | Glutamine amidotransferase subunit pdxT, PHOSPHATE ION, Pyridoxal biosynthesis lyase pdxS, ... | Authors: | Zein, F, Zhang, Y, Kang, Y.N, Burns, K, Begley, T.P, Ealick, S.E. | Deposit date: | 2006-10-18 | Release date: | 2007-01-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural Insights into the Mechanism of the PLP Synthase Holoenzyme from Thermotoga maritima Biochemistry, 45, 2006
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6ASK
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6ASL
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1G4T
| THIAMIN PHOSPHATE SYNTHASE | Descriptor: | 3-(4-AMINO-2-TRIFLUOROMETHYL-PYRIMIDIN-5-YLMETHYL)-4-METHYL-5-(2-PHOSPHONATOOXY-ETHYL)-THIAZOL-3-IUM, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | Authors: | Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E. | Deposit date: | 2000-10-28 | Release date: | 2001-09-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase. Biochemistry, 40, 2001
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1G6C
| THIAMIN PHOSPHATE SYNTHASE | Descriptor: | 2-TRIFLUOROMETHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, 4-METHYL-5-HYDROXYETHYLTHIAZOLE PHOSPHATE, MAGNESIUM ION, ... | Authors: | Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E. | Deposit date: | 2000-11-03 | Release date: | 2001-09-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase. Biochemistry, 40, 2001
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1G4P
| THIAMIN PHOSPHATE SYNTHASE | Descriptor: | 4-AMINO-2-TRIFLUOROMETHYL-5-HYDROXYMETHYLPYRIMIDINE PYROPHOSPHATE, MAGNESIUM ION, THIAMIN PHOSPHATE SYNTHASE | Authors: | Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E. | Deposit date: | 2000-10-27 | Release date: | 2001-09-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase. Biochemistry, 40, 2001
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